A5100407208- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Phagocytosis and Immune Regulation
- Biopolymer Synthesis and Applications
- Chemical Synthesis and Analysis
- Silk-based biomaterials and applications
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Surface Modification and Superhydrophobicity
- Orthopaedic implants and arthroplasty
- Reproductive System and Pregnancy
- Polydiacetylene-based materials and applications
- Immunotherapy and Immune Responses
- Advanced Sensor and Energy Harvesting Materials
- biodegradable polymer synthesis and properties
- Microbial infections and disease research
- Immune cells in cancer
- Hydrogels: synthesis, properties, applications
- Inflammasome and immune disorders
- Click Chemistry and Applications
Lanzhou University
2009-2025
Lanzhou University Second Hospital
2022-2025
Beijing University of Agriculture
2025
Chinese University of Hong Kong, Shenzhen
2023-2025
Wuhan Institute of Bioengineering
2024
Henan University
2024
Henan University of Technology
2023-2024
BeiGene (China)
2024
Shanghai Jiao Tong University
2011-2024
Mayo Clinic
2024
Peptides have important biological functions. However, their susceptibility to proteolysis limits applications. We demonstrated here for the first time, that poly(2-oxazoline) (POX) can work as a functional mimic of peptides. POX-based glycine pseudopeptides, host defense peptide mimic, had potent activities against methicillin-resistant S. aureus, which causes formidable infections. The POX showed activity persisters are highly resistant antibiotics. aureus did not develop resistance owning...
Cell adhesive and other functional peptides (such as RGD, KRSR, YIGSR, VAPG, BMP-2 peptides) are extensively studied utilized in tissue engineering scaffolds biomedical devices to modulate cell functions. Though PEG is frequently used the antifouling layer, it unclear how affects performance of peptides. By analyzing impact at short (OEG4), medium (OEG8), long chain length (PEG2K), we reveal that critical a medium-length enables display their optimal genuine functions adhesion, migration,...
Abstract Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for antibacterial agents that are not prone to antimicrobial resistance. We prepare protease-resistant peptoid polymers with variable C-terminal functional groups using a ring-opening polymerization of N -substituted -carboxyanhydrides (NNCA), which can provide easily from the one-pot synthesis. study optimal polymer displays effective activity against MRSA planktonic and persister cells, eradication highly...
The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy. formation biofilms is one the main reasons resistance. complexity chemical composition physical structure elimination mature difficult problem. highly antibiotic resistant property urgently calls for potent antimicrobial agents novel antibiofilm strategies. Researchers have made lot efforts in this field. Here we review current strategies eliminate progress related drug delivery...
Drug-resistant bacterial infections have caused serious threats to human health and call for effective antibacterial agents that low propensity induce antimicrobial resistance. Host defense peptide-mimicking peptides are actively explored, among which poly-β-l-lysine displays potent activity but high cytotoxicity due the helical structure strong membrane disruption effect. Here, we report an strategy optimize by switching disrupting penetrating intracellular targeting breaking using racemic...
To study the structure of a homogenous major histocompatibility complex (MHC) class I molecule containing single bound peptide, recombinant mouse H-2Kb, beta 2-microglobulin (beta 2m), and fragment vesicular stomatitis virus (VSV) nuclear capsid protein, VSV-(N52-59) octapeptide (Arg-Gly-Tyr-Val-Tyr-Gln-Gly-Leu), was prepared by exploiting high-yield bacterial expression system in vitro cocomplex formation. The H-2Kb revealed its similarity to three human HLA molecules, consistent with high...
Poly-β-peptide 20 : 80 Bu DM displays broad spectrum antibacterial activities, rapid bacterial killing and no susceptibility to antimicrobial resistance.
Abstract Cell adhesion has tremendous impact on the function of culture platforms and implants. Cell-adhesive proteins peptides have been extensively used for decades to promote cell adhesion, however, their application suffers from easy enzymatic degradation, difficulty in large-scale preparation expensiveness. To develop next-generation cell-adhesive materials, we mimic functions mechanisms RGD KRSR design cationic-hydrophobic amphiphilic β-amino acid polymers that are stable upon...
The functions of implants like medical devices are often compromised by the host's foreign-body response (FBR). Herein, we report development low-FBR materials inspired serine-rich sericin from silk. Poly-β-homoserine (β-HS) consist hydrophilic unnatural amino acid β-homoserine. Self-assembled monolayers (SAMs) β-HS resist adsorption diverse proteins, as well adhesion cells, platelets, and microbes. Experiments lasting up to 3 months revealed that, while implantation with control PEG...
Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content low immunogenic silk sericin, the D-serine as neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials mitigating FBR. Here we report highly water soluble, biocompatible easily accessible PSer hydrogels that cause negligible inflammatory after subcutaneous implantation mice for 1 week 2 weeks. No obvious collagen capsulation...
New antifungals are urgently needed to combat invasive fungal infections, due limited types of available antifungal drugs and frequently encountered side effects, as well the quick emergence drug-resistance. We previously developed amine-pendent poly(2-oxazoline)s (POXs) synthetic mimics host defense peptides (HDPs) have antibacterial properties, but with poor activity. Hereby, we report finding short guanidinium-pendent POXs, inspired by cell-penetrating peptides, HDPs display potent...
Abstract Biocompatible and proteolysis‐resistant poly‐β‐peptides have broad applications are dominantly synthesized via the harsh water‐sensitive ring‐opening polymerization of β‐lactams in a glovebox or using Schlenk line, catalyzed by strong base LiN(SiMe 3 ) 2 . We developed controllable water‐insensitive β‐amino acid N‐thiocarboxyanhydrides (β‐NTAs) that can be operated open vessels to prepare high yields, with diverse functional groups, variable chain length, narrow dispersity defined...
Abstract Hydrogels have been extensively used in many fields. Current synthesis of functional hydrogels requires incorporation molecules either before or during gelation via the pre-organized reactive site along polymer chains within hydrogels, which is tedious for and not flexible different types hydrogels. Inspired by sandcastle worm, we develop a simple one-step strategy to functionalize wet using bearing an adhesive dibutylamine-DOPA-lysine-DOPA tripeptide. This tripeptide can be easily...
The high mortality rate of invasive fungal infections and quick emergence drug-resistant pathogens urgently call for potent antifungal agents. Inspired by the cell penetrating peptide (CPP) octaarginine (R8), we elongated to 28 residues poly(d,l-homoarginine) obtain toxicity against both fungi mammalian cells. Further incorporation glutamic acid shields positive charge density introduces partial zwitterions in obtained optimal polymer that displays activity superior drugs, excellent...
The accumulation of antibiotics in the aquatic environment is increasingly becoming a risk to health animal. purpose this study was investigate acute and chronic toxicity florfenicol (FF) zebrafish. A 56-day test followed 96-h test. divided into five FF concentration groups: 0 mg/L (C), 5 (T5), 10 (T10), 20 (T20) 40 (T40). Each group had replicates, with Zebrafish per replicate. results showed that 96 h-LC50 greater than 2000 mg/L, indicating low toxicity. exposure concentrations exceeding...
Multidrug-resistant (MDR) bacteria have emerged quickly and caused serious nosocomial infections. It is urgent to develop novel antimicrobial agents for treating MDR bacterial In this study, we isolated 45 strains of from hospital patients found shockingly that most these were drugs. This inspired us explore peptide polymers as synthetic mimics host defense peptides in combating drug-resistant the formidable challenge. We polymer 80:20 DM:Bu (where DM a hydrophilic/cationic subunit Bu...