A5072697895- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Liver Diseases and Immunity
- Trace Elements in Health
- Organ Transplantation Techniques and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2016-2025
Hefei University of Technology
2025
Aerospace Center Hospital
2025
GlaxoSmithKline (India)
2024
Nanjing Foreign Language School
2024
Beijing Friendship Hospital
2024
Aims Community College
2024
State Grid Corporation of China (China)
2024
Academy of Military Medical Sciences
2024
Abstract Objective To assess the efficacy and safety of hydroxychloroquine plus standard care compared with alone in adults coronavirus disease 2019 (covid-19). Design Multicentre, open label, randomised controlled trial. Setting 16 government designated covid-19 treatment centres China, 11 to 29 February 2020. Participants 150 patients admitted hospital laboratory confirmed were included intention treat analysis (75 assigned care, 75 alone). Interventions Hydroxychloroquine administrated at...
Background & AimsWe performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.MethodsWe collected data on total 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers China. We demographic, history, treatment, laboratory, disease severity, mortality all patients. Investigators each site were asked complete causality assessments for case whose diagnosis discharge was (n = 29,478)...
The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis, irrespective aetiology, remains controversial. This study aimed to clarify the clinicopathological characteristics patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective and develop new diagnostic criteria prognostic score for such patients.The clinical data from 1322 hospitalised acute decompensation cirrhosis or severe injury due chronic (CHB) at 13 centres China were used criteria.Of assessed...
•In total, 17,374 patients with viral and non-viral hepatitis from 11 global prospective cohorts/trials were studied.•An HCC risk score (called the aMAP score, ranging 0 to 100), which involves only age, male, albumin–bilirubin platelet data, was developed validated.•The had excellent discrimination calibration in assessing 5-year irrespective of aetiology ethnicity.•Patients <50, accounting for 44% overall population, an incidence <0.2% per year. Background & AimsHepatocellular carcinoma...
On-treatment levels of hepatitis B surface antigen (HBsAg) may predict response to peginterferon (PEG-IFN) therapy in chronic (CHB), but previously proposed prediction rules have shown limited external validity. We analyzed 803 HBeAg-positive patients treated with PEG-IFN three global studies available HBsAg measurements. A stopping-rule based on absence a decline from baseline was compared prediction-rule that uses <1,500 IU/mL and >20,000 identify high low probabilities response....
Nirmatrelvir-ritonavir has been authorized for emergency use by many countries the treatment of coronavirus disease 2019 (Covid-19). However, supply falls short global demand, which creates a need more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome 2 (SARS-CoV-2).We conducted phase 3, noninferiority, observer-blinded, randomized trial during outbreak caused B.1.1.529 (omicron) variant SARS-CoV-2. Symptomatic adults mild-to-moderate...
Abstract Objectives To assess the efficacy and safety of hydroxychloroquine (HCQ) plus standard–of–care (SOC) compared with SOC alone in adult patients COVID–19. Design Multicenter, open–label, randomized controlled trial. Setting 16 government–designated COVID–19 treatment centers China through 11 to 29 February 2020. Participants 150 hospitalized laboratory confirmed were included intention treat analysis. 75 assigned HCQ alone. Interventions was administrated a loading dose 1, 200 mg...
Activation of death receptors and mitochondrial damage are well-described common apoptotic pathways. Recently, a novel pathway via endoplasmic reticulum (ER) stress has been reported. We assessed the role tauroursodeoxycholic acid (TUDCA) in inhibition caspase-12 activation its effect on calcium homeostasis an ER stress-induced model apoptosis. The human liver-derived cell line, Huh7, was treated with thapsigargin (TG) to induce stress. Typical morphologic changes preceded development...
As there is currently a lack of consensus on the most appropriate dose and duration peginterferon alfa-2a (PEG-IFNα-2a) therapy in hepatitis B e antigen (HBeAg)-positive patients, efficacy safety either 24 or 48 weeks' 90 μg/week 180 doses were compared. HBeAg-positive patients (n = 544; 34% genotype B, 51% C) randomized to receive PEG-IFNα-2a (2 × 2 factorial design) for weeks at included per-protocol population. The primary endpoint noninferiority study was HBeAg seroconversion 6 months...
This paper investigates two surface electromyogram (sEMG)-based control strategies developed for a power-assist exoskeleton arm. Different from most of the existing position approaches, this develops force methods to make robot behave like humans in order provide better assistance. The is directly attached user's body and activated by sEMG signals muscles, which reflect motion intention. In first proposed method, forces agonist antagonist muscles pair are estimated, their difference used...
Abstract Background Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) an effective tool to silence gene expression post‐transcriptionally. Therefore, we conducted investigation determine if intraportal vein siRNA injection targeting CTGF inhibits on rat liver vivo and furthermore whether it protects the from fibrosis. Methods Some rats received carbon tetrachloride (CCl 4 ) by subcutaneous injections...
Abstract The diagnostic and prognostic criteria of acute-on-chronic liver failure (ACLF) were developed in patients with no Hepatitis B virus (HBV) cirrhosis (CANONIC study). aims this study to evaluate whether the (CLIF-C organ score; CLIF-C OFs) can be used classify patients; score ACLF score) could provide information HBV cirrhotic ACLF. 890 associated acute decompensation (AD) enrolled. Using OFs, 33.7% (300 patients) diagnosed as was more common younger those previous history...
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and usually develops in patients with liver cirrhosis (LC). Biomarkers that discriminate HCC from LC are important but limited. In present study, an ultraperformance liquid chromatography–mass spectrometry (UPLC–MS)-based metabonomics approach was used to characterize serum profiles (n = 82), 48), healthy subjects 90), accuracy of UPLC–MS alpha-fetoprotein (AFP) levels were compared for their use diagnosis. By...
Fulminant hepatic failure (FHF) is a clinical syndrome characterized by sudden and severe impairment of liver function. Mesenchymal stem cells (MSCs) have been proposed as promising therapeutic approach for FHF. In this study we used Propionibacterium acnes ( P. )-primed, lipopolysaccharide (LPS)-induced injury in mice an animal model human We demonstrated that administration MSCs significantly ameliorated improved the survival rates subjected to plus LPS-induced Allogeneic showed similar...
Chronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral host genetic characteristics that may influence disease manifestations clinical management.In this cross-sectional observational study, treatment-naïve Han ethnic adults with recently confirmed chronic HCV were enrolled at 28 hospitals across genotype interleukin 28B (IL28B) genotypes determined compared patient demographic parameters medical status.Among...
Abstract Increasing evidence has indicated that bone morphogenetic protein 2 (BMP2) coordinates with microRNAs (miRNAs) to form intracellular networks regulating mesenchymal stem cells (MSCs) osteogenesis. This study aimed identify specific miRNAs in rat adipose-derived (ADSCs) during BMP2-induced osteogenesis, we selected the most significantly down-regulated miRNA, miR-146a, systematically investigate its role osteogenesis and regeneration. Overexpressing miR-146a notably repressed ADSC...
INTRODUCTION: It is unclear whether entecavir (ETV) and tenofovir disoproxil fumarate (TDF) differ in their effectiveness for preventing hepatocellular carcinoma (HCC) patients with chronic hepatitis B (CHB). METHODS: This retrospective cohort study analyzed an international consortium that encompassed 19 centers from 6 countries or regions composed of previously untreated CHB then treated either ETV TDF monotherapy. Those who developed HCC before antiviral treatment within 1 year therapy...
There is no satisfactory way to identify patients who will maintain a response after discontinuation of nuleos(t)ide analogue therapy for chronic hepatitis B virus (HBV) infection. We investigated whether with negative results from tests HBV DNA and RNA (double negative) at the end treatment long-term treatment.We performed post-hoc analysis data 2-year multi-center randomized controlled trial, its extension trials, on 130 infection were positive HB e antigen (HBeAg-positive; mean age, 30.8...
Long-term incidences and baseline determinants of functional cure (hepatitis B surface antigen [HBsAg] seroclearance) during entecavir (ETV) or tenofovir disoproxil fumarate (TDF) treatment are incompletely understood.This is an international multicenter cohort study treatment-naive patients with chronic hepatitis who started ETV TDF without cancer. Patients were observed for HBsAg seroclearance until death loss to follow-up. We calculated the explored using competing risk regression.The...