A5058768792- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Chemical Synthesis and Analysis
- Polydiacetylene-based materials and applications
- Biopolymer Synthesis and Applications
- Chemical Synthesis and Reactions
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Fungal Infections and Studies
- Bacterial biofilms and quorum sensing
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Advanced Sensor and Energy Harvesting Materials
- Recycling and Waste Management Techniques
- Graphene and Nanomaterials Applications
- Microplastics and Plastic Pollution
- Silk-based biomaterials and applications
- Antimicrobial Resistance in Staphylococcus
- Polymer Surface Interaction Studies
- Probiotics and Fermented Foods
- Synthesis of heterocyclic compounds
- Fungal Plant Pathogen Control
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
East China University of Science and Technology
2019-2024
Ministry of Education of the People's Republic of China
2020
Fudan University
2020
State Key Laboratory of Bioreactor Engineering
2020
Peptides have important biological functions. However, their susceptibility to proteolysis limits applications. We demonstrated here for the first time, that poly(2-oxazoline) (POX) can work as a functional mimic of peptides. POX-based glycine pseudopeptides, host defense peptide mimic, had potent activities against methicillin-resistant S. aureus, which causes formidable infections. The POX showed activity persisters are highly resistant antibiotics. aureus did not develop resistance owning...
Abstract Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for antibacterial agents that are not prone to antimicrobial resistance. We prepare protease-resistant peptoid polymers with variable C-terminal functional groups using a ring-opening polymerization of N -substituted -carboxyanhydrides (NNCA), which can provide easily from the one-pot synthesis. study optimal polymer displays effective activity against MRSA planktonic and persister cells, eradication highly...
New antifungals are urgently needed to combat invasive fungal infections, due limited types of available antifungal drugs and frequently encountered side effects, as well the quick emergence drug-resistance. We previously developed amine-pendent poly(2-oxazoline)s (POXs) synthetic mimics host defense peptides (HDPs) have antibacterial properties, but with poor activity. Hereby, we report finding short guanidinium-pendent POXs, inspired by cell-penetrating peptides, HDPs display potent...
Abstract Hydrogels have been extensively used in many fields. Current synthesis of functional hydrogels requires incorporation molecules either before or during gelation via the pre-organized reactive site along polymer chains within hydrogels, which is tedious for and not flexible different types hydrogels. Inspired by sandcastle worm, we develop a simple one-step strategy to functionalize wet using bearing an adhesive dibutylamine-DOPA-lysine-DOPA tripeptide. This tripeptide can be easily...
Potent and selective antifungal agents are urgently needed due to the quick increase of serious invasive fungal infections limited drugs available. Microbial metabolites have been a rich source antimicrobial inspired authors design obtain potent agents, poly(DL-diaminopropionic acid) (PDAP) from ring-opening polymerization β-amino acid N-thiocarboxyanhydrides, by mimicking ε-poly-lysine. PDAP kills cells penetrating cytoplasm, generating reactive oxygen, inducing apoptosis. The optimal...
The high mortality rate of invasive fungal infections and quick emergence drug-resistant pathogens urgently call for potent antifungal agents. Inspired by the cell penetrating peptide (CPP) octaarginine (R8), we elongated to 28 residues poly(d,l-homoarginine) obtain toxicity against both fungi mammalian cells. Further incorporation glutamic acid shields positive charge density introduces partial zwitterions in obtained optimal polymer that displays activity superior drugs, excellent...
Multidrug-resistant (MDR) bacteria have emerged quickly and caused serious nosocomial infections. It is urgent to develop novel antimicrobial agents for treating MDR bacterial In this study, we isolated 45 strains of from hospital patients found shockingly that most these were drugs. This inspired us explore peptide polymers as synthetic mimics host defense peptides in combating drug-resistant the formidable challenge. We polymer 80:20 DM:Bu (where DM a hydrophilic/cationic subunit Bu...
Host defense peptides (HDPs) are one of the potentially promising agents for infection diseases due to their broad spectrum and low resistance rate, but clinical applications limited by proteolytic instability, high-cost, complicated synthesis process. Here, we report a host-defense-peptide-mimicking β-peptide polymer that resists proteolysis have enhanced activity under physiological conditions, excellent antimicrobial efficiency even at high density bacteria, cost preparation. The...
Invasive fungal infections, including meningitis, cause a high mortality rate due to few available antifungal drugs and frequently associated side effects quick emergence of drug-resistant fungi. The restrictive permeability the blood–brain barrier (BBB) further limits efficacy agents substantially in treating meningitis. Hereby, we design synthesize guanidinium-functionalized poly(2-oxazoline)s by mimicking cell-penetrating peptides. optimal polymer, PGMeOx10 bearing methylene spacer arm,...
Multidrug resistant (MDR) Pseudomonas aeruginosa has caused serious nosocomial infections owing to its high intrinsic resistance and ease of acquiring common antibiotics. There is an urgent need develop antimicrobial agents against MDR aeruginosa. Here we report a 27-mer peptide polymer 90 : 10 DLL BLG, as synthetic mimic host defense peptide, that displayed potent in vitro vivo activities multiple strains clinically isolated aeruginosa, performing even better than antibiotics within our...
An α/β chimeric polypeptide molecular brush shows excellent performance in eradicating established biofilms, persister cells, and clinically isolated multi-drug resistant Gram-positive bacteria.
Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro , as well strong therapeutic potential vivo a promising alternative to antibiotics aquaculture.
Abstract Peptides have important biological functions. However, their susceptibility to proteolysis limits applications. We demonstrated here for the first time, that poly(2‐oxazoline) (POX) can work as a functional mimic of peptides. POX‐based glycine pseudopeptides, host defense peptide mimic, had potent activities against methicillin‐resistant S. aureus , which causes formidable infections. The POX showed activity persisters are highly resistant antibiotics. did not develop resistance...
Abstract New antifungals are urgently needed to combat invasive fungal infections, due limited types of available antifungal drugs and frequently encountered side effects, as well the quick emergence drug‐resistance. We previously developed amine‐pendent poly(2‐oxazoline)s (POXs) synthetic mimics host defense peptides (HDPs) have antibacterial properties, but with poor activity. Hereby, we report finding short guanidinium‐pendent POXs, inspired by cell‐penetrating peptides, HDPs display...
The high-mortality invasive fungal infections seriously threaten the lives of immunocompromised people. Host defense peptides and cell-penetrating are representative membrane-active with different functions. Among them, host mimicking is a valid strategy in design synthetic antifungal agents. Despite brilliance field intracellular delivery, potential their mimics for designing agents has been overlooked. In this concept article, we describe structural polymers as peptides, highlight...
Poly(2-oxazoline) (POX) wurden als eine neue Klasse von Abwehrpeptiden erforscht. Wie R. Liu und Mitarbeiter in ihrem Forschungsartikel auf S. 6474 berichten, zeigen diese funktionellen Peptidmimetika starke antimikrobielle In-vitro- In-vivo-Aktivität gegen Methicillin-resistentes Staphylococcus aureus (MRSA), indem sie die Antibiotikaresistenz abschwächen antibiotikatolerante MRSA durch einen reaktiven Sauerstoffspezies (ROS) basierenden Mechanismus abtöten.
The pressure of antimicrobial resistance has forced many countries to reduce or even prohibit the use antibiotics in feed. Therefore, it is urgent need develop alternatives control infectious diseases feed and aquaculture. To address this long-lasting challenge, we prepared peptide polymers that display potent broad-spectrum activity against common pathogenic bacteria aquaculture, low hemolysis cytotoxicity, doesn’t induce cross antibiotics. optimal polymer demonstrates strong vivo...