A5075118341- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Micro and Nano Robotics
- Bacterial biofilms and quorum sensing
- Advanced biosensing and bioanalysis techniques
- Photoacoustic and Ultrasonic Imaging
- Sulfur Compounds in Biology
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Antimicrobial Peptides and Activities
- Ferroptosis and cancer prognosis
- Amoebic Infections and Treatments
- Advanced Breast Cancer Therapies
- Extracellular vesicles in disease
- Pancreatic function and diabetes
- Inhalation and Respiratory Drug Delivery
- Ocular Infections and Treatments
- Insect and Pesticide Research
- Cellular Mechanics and Interactions
- Wound Healing and Treatments
- Fluid Dynamics and Turbulent Flows
- Cancer Research and Treatments
- Dental Research and COVID-19
Zhejiang University-University of Edinburgh Institute
2023-2025
Human Longevity (United States)
2024
University of California, San Diego
2022-2024
Second Affiliated Hospital of Zhejiang University
2019-2024
Zhejiang University
2019-2023
Shandong University of Traditional Chinese Medicine
2022
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021
Hangzhou Xixi hospital
2019
Lanzhou University
2012
Lanzhou Institute of Chemical Physics
2012
Microalgae, a naturally present unicellular microorganism, can undergo light photosynthesis and have been used in biofuels, nutrition, etc. Here, we report that engineered live microalgae be delivered to hypoxic tumor regions increase local oxygen levels resensitize resistant cancer cells both radio- phototherapies. We demonstrate the environment tumors is markedly improved by situ-generated through microalgae-mediated photosynthesis, resulting notably radiotherapeutic efficacy. Furthermore,...
Abstract Biohybrid microswimmers have recently shown to be able actively perform in targeted delivery and vitro biomedical applications. However, more envisioned functionalities of the aimed at vivo treatments are still challenging. A photosynthetic biohybrid nanoswimmers system (PBNs), magnetic engineered bacteria‐ Spirulina platensis , is utilized for tumor‐targeted imaging therapy. The PBNs fabricated by superparamagnetic magnetite (Fe 3 O 4 NPs) via a dip‐coating process, enabling its...
Abstract Protecting the whole small intestine from radiation-induced intestinal injury during radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Amifostine is a promising selective radioprotector for normal tissues. However, its oral application in radioprotection challenging. Herein, we use microalga Spirulina platensis as microcarrier to construct delivery system. The system shows comprehensive drug accumulation and effective that significantly superior free...
Abstract Nanofibrous biocomposite scaffolds of poly(vinyl alcohol) (PVA) and graphene oxide (GO) were prepared by using electrospinning method. The microstructure, crystallinity, morphology the characterized through X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM). mechanical properties investigated tensile testing. Moreover, Mouse Osteoblastic Cells (MC3T3‐E1) attachment proliferation on nanofibrous MTT...
Overproduced hydrogen sulfide (H2 S) is of vital importance for the progress colon cancer and promotes cellular proliferation. Devising pharmacological nanomaterials tumor-specific H2 S activation will be significant precise treatment. Herein, a biocompatible fusiform iron oxide-hydroxide nanospindles (FeOOH NSs) nanosystem magnetic resonance imaging (MRI), ferroptosis, based cascade reaction-enhanced combinational treatment developed. The FeOOH NSs can effectively scavenge endogenous via...
Colorectal cancer is a common malignancy occurring in the digestive system and ranks second mortality worldwide. In colorectal cancer, hydrogen sulfide (H2S) selectively upregulated, resulting further exacerbation of disease. Therefore, clearance H2S regulation enzymes on pathways are great significance for therapy.Here, we investigated content various clinical tumor tissues from patients confirmed that overproduced concentration cancer. Accordingly, developed an H2S-responsive nanoplatform...
Rationale: Chronic wounds are one of the common complications diabetes. Due to physiological conditions diabetic patients, these more susceptible bacterial infections and formation biofilms, leading inefficiency conventional antibiotic treatment. Methods: Here, hollow mesoporous silica nanoparticles (HMSN) were used as nanocarriers for co-delivery azithromycin (AZM) glucose oxidase (GOX), achieving a remarkable synergistic effect in chronic wounds. GOX possesses catalytic ability consume...
The oral form of insulin is more convenient and has better patient compliance than subcutaneous or intravenous insulin. Current preparations, however, cannot overcome the enzyme barrier, chemical epithelial barrier gastrointestinal tract completely. In this study, a microalgae-based delivery strategy (CV@INS@ALG) was developed using Chlorella vulgaris (CV)-based system cross-linking with sodium alginate (ALG). CV@INS@ALG could protect from harsh gastric conditions, achieve pH-responsive drug...
Rationale: Endophthalmitis, which is one of the severest complications cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing its complicated microenvironment, including both local bacterial infection severe inflammation.It urgent develop a comprehensive treatment for anti-bacterial anti-inflammatory effects.Methods: Herein, we developed AuAgCu2O-bromfenac sodium nanoparticles (AuAgCu2O-BS NPs), was designed combine effects integrated therapy...
Pyogenic liver abscess and keratitis are aggressive bacterial infections the treatment has failed to eradicate bacteria in infectious sites completely owing currently severe drug resistance existing antibiotics. Here, we report a simple efficient one-step development of ultrasmall non-antibiotic nanoparticles (ICG-Ga NPs) containing clinically approved gallium (III) (Ga3+) targeting indocyanine green (ICG) molecules multi-drug resistant (MDR) thought synergetic effect photodynamic therapy...
Rationale: Hypoxia is one of the crucial restrictions in cancer radiotherapy (RT), which leads to hypoxia-associated radioresistance tumor cells and may result sharp decline therapeutic efficacy. Methods: Herein, living photosynthetic microalgae (Chlorella vulgaris, C. vulgaris), were used as oxygenators, for situ oxygen generation relieve hypoxia. We engineered surface vulgaris (CV) with calcium phosphate (CaP) shell by biomineralization, form a biomimetic system (CV@CaP) efficient delivery...
During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations performed in non-primate animal models, there is few pilot studies non-human primate strongly hindering clinical translation AIE (AIEgens). Herein, we present systemic multifaceted demonstration an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice rabbits) to rhesus...
Multifunctional antimicrobial strategies are urgently needed to treat methicillin-resistant Staphylococcus aureus (MRSA) caused pneumonia due its increasing resistance, enhanced virulence, and high pathogenicity. Here, we report that lysostaphin, a bacteriolytic enzyme, encapsulated within poly(lactic-co-glycolic acid) microspheres (LyIR@MS) specially treats planktonic MRSA bacteria, mature biofilms, related pneumonia. Optimized LyIR@MS with suitable diameters could deliver sufficient amount...
Host defense peptides (HDPs) are one of the potentially promising agents for infection diseases due to their broad spectrum and low resistance rate, but clinical applications limited by proteolytic instability, high-cost, complicated synthesis process. Here, we report a host-defense-peptide-mimicking β-peptide polymer that resists proteolysis have enhanced activity under physiological conditions, excellent antimicrobial efficiency even at high density bacteria, cost preparation. The...
<title>Abstract</title> Inorganic nanoparticles play important roles in cancer treatment, but the issues of biodegradable properties, and tumor penetration restricted further clinical application. Aiming at low efficiency toxic side effects problems existing current treatment cancer, this work has proposed to design metabolizable multistage structural silica-sulfide hafnium (SiO<sub>2</sub>-HfS<sub>2</sub>) nanotherapeutics for synergistically enhanced chemoradiotherapy cancer. The...
We aimed to test the safety of CDK4/6 inhibitor palbociclib in combination with EGFR cetuximab and PD-L1 avelumab recurrent/metastatic head neck squamous cell carcinoma (R/M HNSCC). This phase I study enrolled eligible adult patients R/M HNSCC into three sequential single dose-escalation cohorts (75, 100, 125 mg) PO daily on days 1 21 a 28-day cycle 10 mg/kg IV every 2 weeks 400 mg/m2 day 1, then 250 weekly thereafter. The followed 3 + design no intra-patient escalation. primary objective...
It is well known that drag reduction occurs when the flow passing by a grooved circular cylinder at certain Reynolds numbers, which has been used as powerful energy saving method in broad range of circumstances. However, challenge here how to evaluate combined effects depth, width and location given triangular groove set covering half cylindrical surface area. A useful approach quantitatively analyze influence these different factors on using response methodology described here. The...
Abstract Background Theranostic nanoparticles (NPs) have achieved rapid development owing to their capacity for personalized multimodal diagnostic imaging and antitumor therapy. However, the efficient delivery bulk accumulation of NPs in tumors are still decisive factors improving therapeutic effect. It is urgent seek other methods alters tumor microenvironment (like vascular permeability density) enhancing efficiency at site. Methods Herein, we developed a Raman-tagged hollow gold...
Oral and oropharyngeal cancer have low survival rates, incidence continues to increase.
We report a versatile nanoplatform with size tunability, pH-responsiveness, active targeting and radio-/chemotherapeutic features as an efficient tool for tumor therapy.