A5039879243- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Ultrasound and Hyperthermia Applications
- Advanced biosensing and bioanalysis techniques
- Oral microbiology and periodontitis research
- Photodynamic Therapy Research Studies
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- ZnO doping and properties
- Porphyrin and Phthalocyanine Chemistry
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Cancer, Hypoxia, and Metabolism
- Anodic Oxide Films and Nanostructures
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Phosphodiesterase function and regulation
- Peptidase Inhibition and Analysis
- Oral and gingival health research
- Wastewater Treatment and Nitrogen Removal
- Copper-based nanomaterials and applications
Jilin University
2014-2025
State Key Laboratory on Integrated Optoelectronics
2025
Sun Yat-sen University
2021-2025
Hospital of Stomatology, Sun Yat-sen University
2021-2025
Hanzhong People's Hospital
2025
Shanghai University
2024
Hebei University
2024
Jilin Medical University
2024
Shaanxi Normal University
2012-2023
Xi'an Medical University
2023
Abstract Macrophage polarization toward M1 phenotype (pro‐inflammation) is closely associated with the destructive phase of periodontal inflammation. Nanoceria verified to inhibit macrophages by favorable ability reactive oxygen species (ROS) scavenging. However, function nanoceria on macrophage M2 (anti‐inflammation) in reparative inflammation quite limited. In this work, introducing an antioxidant drug quercetin onto nano‐octahedral ceria, synergistic and intense regulation host immunity...
Numerous nanomedicines currently emerge to reduce the dramatic threat in antibiotics resistance for antibacterial application against severe bacterial infections, while it is restricted by over-reacted immune response pathogenic bacteria. Herein, enzymatic activity introduced into zeolitic imidazolate framework-8 (ZIF-8) achieve sterilization releasing Zn ions, as well inflammation regulation through variable valence of Mn ions that are uniformly doped its framework. Within this simple metal...
Abstract The hypoxic microenvironment, continuous oxygen consumption, and poor excitation light penetration depth during antimicrobial photodynamic therapy (aPDT) tremendously hinder the effects on bacterial inactivation. Herein, a smart nanocomposite with oxygen‐self‐generation is presented for enhanced selective antibacterial properties against anaerobe‐induced periodontal diseases. By encapsulating Fe 3 O 4 nanoparticles, Chlorin e6 Coumarin 6 in amphiphilic silane, combined (red...
The repair of infected bone defects with irregular shapes is still a challenge in clinical work. Infected are faced several major concerns: the complex defects, intractable bacterial infection and insufficient osseointegration. To solve these problems, we developed personalized MXene composite hydrogel scaffold GelMA/β-TCP/sodium alginate (Sr2+)/MXene (Ti3C2) (GTAM) photothermal antibacterial osteogenic abilities by 3D printing. In vitro, GTAM scaffolds could kill both Gram-positive...
Abstract The rising dangers of bacterial infections have created an urgent need for the development a new generation antibacterial technologies and therapeutics. Antibacterial photodynamic therapy (PDT), considered as noninvasive treatment with no drug resistance, has become promising photochemistry‐involved strategy. Titanium oxide (TiO 2 ) is proved to be very efficient PDT agent among photosensitive materials, while property large bandgap TiO makes it only excited by ultraviolet light,...
Simultaneous photodynamic therapy (PDT) and photothermal (PTT) can reduce the risks of drug leakage, body burden, preparation complexity in traditional combination PDT/PTT. Here, a versatile nanoporphyrin (Pp18-lipos) self-assembled from lipid-purpurin 18 conjugates (Pp18-lipids) pure lipids is presented. The as-prepared Pp18-lipos with 2 mol% Pp18-lipids perform effective PDT fluorescence imaging. 65 Pp18 potent PTT photoacoustic chelation Mn2+ endows Pp18-lipids-Mn2+ high T1 -weighted...
Targeting drug delivery remains a challenge in various disease treatment including cancer. The local deposit could be greatly enhanced by some external stimuli-responsive systems. Here we develop pluronic P123/F127 polymeric micelles (M) encapsulating curcumin (Cur) that are permeabilized directly focused ultrasound, which ultrasound triggers release. Tumor preferential accumulation and site-specific sonochemotherapy were then evaluated. Cur-loaded mixed (Cur-M) exhibited longer circulating...
Hypoxia detection is emphasized with attention due to tumor and related diseases diagnosis, which could provide useful methods for exploring the mechanism of hypoxic tumor. Herein, we report two unprecedented hypoxia-sensitive probes that specifically switch-on their near-infrared fluorescence signals in presence hypoxia up-regulated enzymes (nitroreductase cytochrome P450 reductase). The were designed by featuring decomposition IR-780 coupled activatable p-nitrobenzyl or azo moiety, exhibit...
Nowadays the multifunctional approaches to kill oral bacteria based on various nanocomposites have made great progress against periodontal infections, while material structure and its functional integration are still insufficient. Herein, this work proposes a therapeutic strategy of chemodynamical therapy (CDT) photothermal (PTT) in monocrystals effectively enhance synergistic treatment. The CuS/MnS@MnO2 consisting hexagonal CuS/MnS nano-twin-crystal with shell layer MnO2 is developed. In...
UTMD-assisted intelligent DVDMS encapsulate iRGD-Liposomes mediate SDT with deep tumor penetration and specific targeting ability enhanced anti-glioma efficacy.
Concentrated growth factor (CGF) is a newly generated complex that comprises fibrin matrix incorporating factors and plasmatic leukocyte cytokines. It has been widely used in bone regenerative medicine. However, the effect of CGF on peripheral nerve regeneration had not previously investigated. The aim present study was to evaluate possibility using for by i) investigating proliferation Schwann cells (SCs) secretion neurotrophic (NGF) glial cell line‑derived (GDNF) vitro; ii) analyzing...
Amphiphilic polymeric prodrugs show improved therapeutic indices with respect to traditional hydrophobic anticancer drugs because these can self-assemble into nanoparticles, prolong the circulation of in blood, improve accumulation disease site, reduce side effects drugs, and achieve effect. Here, we describe a novel pH/reduction dual-responsive prodrug, abbreviated as CPT-ss-poly(BYP-hyd-DOX-co-EEP), simultaneous conjugating camptothecin (CPT) doxorubicin (DOX), wherein BYP EEP represent...
Abstract Nanozymes with peroxidase‐mimic activity have recently emerged as effective strategies for eliminating infections. However, challenges in enhancing catalytic activities and the ability to target bacteria hindered broader application of nanozymes bacterial Herein, a novel nanozyme based on mesoporous CeO 2 nanosphere meso‐tetra(4‐carboxyphenyl)porphine (TCPP) encapsulated within pathogen‐activated macrophage membranes, demonstrates photodynamic capability coupled photo‐enhanced...