A5011188159- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- 14-3-3 protein interactions
- Mitochondrial Function and Pathology
- Dialysis and Renal Disease Management
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Dementia and Cognitive Impairment Research
- Trace Elements in Health
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- High Altitude and Hypoxia
- Signaling Pathways in Disease
- Apelin-related biomedical research
- Kruppel-like factors research
- FOXO transcription factor regulation
Wenzhou Medical University
2013-2025
First Affiliated Hospital of Wenzhou Medical University
2019-2025
University of Houston
2024
Zhejiang Lab
2022
Huazhong University of Science and Technology
2017-2020
Alzheimer's disease (AD) is the most common neurodegenerative with limited therapeutic strategies. Cell cycle checkpoint protein kinase 1 (Chk1) a Ser/Thr which activated in response to DNA damage, latter an early event AD. However, whether damage-induced Chk1 activation participates development of AD and inhibition ameliorates AD-like pathogenesis remain unclarified. Here, we demonstrate that activity levels phosphatase 2A (PP2A) inhibitory CIP2A are elevated human brains, APP/PS1...
Abstract Background Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system. Silent information regulator sirtuin 1 (SIRT1) may deacetylate and suppress forkhead box O (FOXO) activities to promote neuronal survival. FOXO1 involved in regulation of metabolism, senescence, stress response, apoptosis. Moreover, endoplasmic reticulum (ERS) mediates cell Therefore, this study aimed determine whether downregulation SIRT1 expression exacerbates cognitive...
<title>Abstract</title> Niemann-Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disorder (LSD) caused by the deficiency of acid sphingomyelinase (ASMD), which encoded <italic>Smpd1</italic> gene. ASMD impacts multiple organ systems in body, including cardiovascular system. This study first to characterize cardiac pathological changes mice under baseline conditions, offering novel insights into implications NPD. Using histological analysis, biochemical assays, and...
Codonopsis pilosula polysaccharide (CPPs), a natural products with potentially lower toxicity and better bioavailability has been used in traditional Chinese medicine for 1000s of years neuroprotective mitigates tau pathology Alzheimer's disease (AD) mouse model. However, whether CPPs can relieve AD cognitive defects remains poorly understood. Here we reported that remarkably increased the cell viability PP2A activity, decreased phosphorylation HEK 293/tau cells. Next, employed an...
Casein kinase 2 (CK2) is highly activated in Alzheimer disease (AD) and associated with neurofibrillary tangles formation. Phosphorylated SET, a potent PP2A inhibitor, mediates tau hyperphosphorylation AD. However, whether CK2 phosphorylates SET regulates pathological phosphorylation AD remains unclear. Here we show that phosphorylating at Ser9 induced We found either Aβ treatment or overexpression stimulated activation leading to neurons animal models, while inhibition of by TBB abolished...
Abstract CDK5 activation promotes ischemic neuronal death in stroke, with the recognized mechanism being calpain-dependent p35 cleavage to p25. Here we reported that CDK5-Tyr15 phosphorylation by zinc induced brain injury. and were observed hippocampus of rats had been subjected middle cerebral artery occlusion, both which reversed pretreatment chelator; while calpain ischemia not reversed. Zinc incubation resulted activation, without increasing cultured cells. Site mutation experiment...
Abstract Alzheimer's disease (AD) is characterized with senile plaques formed by Aβ deposition, and neurofibrillary tangles composed of hyperphosphorylated tau protein, which ultimately lead to cognitive impairment. Despite the heavy economic life burdens faced patients AD, effective treatments are still lacking. Previous studies have reported neuroprotective effects FGF10 in CNS diseases, but its role AD remains unclear. In this study, we demonstrated that levels were reduced serum...
Cancerous Inhibitor of PP2A (CIP2A), an endogenous inhibitor, is upregulated and causes reactive astrogliosis, synaptic degeneration, cognitive deficits in Alzheimer's disease (AD). However, the mechanism underlying increased CIP2A expression AD brains remains unclear. We here demonstrated that DNA damage-related Checkpoint kinase 1 (ChK1) activated human 3xTg-AD mice. ChK1-mediated overexpression drives inhibition activates STAT3, then leads to astrogliosis neurodegeneration vitro....
Upregulation of Cancerous Inhibitor PP2A (CIP2A) plays an important role in disease-related phosphorylation tau/APP and tau pathology/Aβ overproduction through inhibiting AD brain. Genistein has been shown to potently reduce CIP2A experimental cancer treatment research. Whether can ameliorate pathology targeting needs further investigation.The inhibitory effects on Aβ cell models have explored. HEK293-T cells were co-transfected with APP plasmids, or incubation at 0, 30, 60 120 µM for 48 h,...
Polyphyllin I (PPI) is a natural phytochemical drug isolated from plants which can inhibit the proliferation of cancer cells. One PPI tumor-inhibitory effects through downregulating expression Cancerous Inhibitor PP2A (CIP2A), latter, found upregulated in Alzheimer's disease (AD) brains and participates development AD. In this study, we explored application experimental AD treatment CIP2A-overexpressed cells 3XTg-AD mice. HEK293 or primary neurons, effectively reduced CIP2A level, activated...
In Alzheimer's disease (AD), decreases in the amount and synaptic localization of AMPA receptors (AMPARs) result weakened activity dysfunction plasticity, leading to impairments cognitive functions. We have previously found that AMPARs are subject lysine acetylation, resulting higher AMPAR stability protein accumulation. Here we report acetylation was significantly reduced AD neurons with Aβ incubation. identified p300 as acetyltransferase responsible for enhancing GluA1 ameliorated...
Synaptic activity increases the resistance of neurons to diverse apoptotic insults; however, underlying mechanisms remain less well understood. Zinc promotes cell survival under varied conditions, but role synaptically released zinc in activity-dependent anti-apoptotic effect is unknown. Using cultured hippocampal slices and primary we show that a typical apoptosis inducer-staurosporine (STP) was able cause concentration-dependent death brain slices; Enhanced synaptic by bicuculline...
Lupus nephritis (LN) is a major end-organ complication of systemic lupus erythematosus (SLE), and the molecular mechanism LN not completely clear. Accumulating pieces evidence indicate potential vital role tRNA-derived small RNAs (tsRNAs) in human diseases. Current study aimed to investigate roles tsRNAs LN.We herein employed high-throughput sequencing screen expression profiles renal tissues control groups. To validate data, we performed quantitative real-time PCR (qRT-PCR) analysis....