A5033092169- Inflammasome and immune disorders
- Atherosclerosis and Cardiovascular Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Calcium signaling and nucleotide metabolism
- Drug Transport and Resistance Mechanisms
- Neurological Disease Mechanisms and Treatments
- Liver Disease and Transplantation
- Calpain Protease Function and Regulation
- Cerebrovascular and genetic disorders
- Adenosine and Purinergic Signaling
- Acute Kidney Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heterotopic Ossification and Related Conditions
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Sphingolipid Metabolism and Signaling
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
University of Houston
2022-2025
Fujian Normal University
2025
Virginia Commonwealth University
2014-2016
Vancomycin ranks amongst the most utilized antimicrobial agents in treatment of serious β-lactam-resistant Gram-positive infections, but its use has been associated with nephrotoxicity. Reduction acute kidney injury (AKI) reported pre-clinical models adjuvant montelukast. The purpose study was to ascertain if montelukast a reduction prevalence vancomycin-associated AKI. In this retrospective cohort study, adult patients who received intravenous vancomycin between January 2020 2024 were...
AdipoRon is a selective adiponectin receptor agonist that inhibits vascular remodeling by promoting the differentiation of arterial smooth muscle cells (SMCs). Our recent studies have demonstrated activation TFEB and its downstream autophagy-lysosomal signaling contribute to adipoRon-induced SMCs. The present study was designed examine whether acid sphingomyelinase (ASM; gene symbol Smpd1) involved in mediating TFEB-autophagy inhibition proliferation/migration results showed adipoRon induced...
<title>Abstract</title> Niemann-Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disorder (LSD) caused by the deficiency of acid sphingomyelinase (ASMD), which encoded <italic>Smpd1</italic> gene. ASMD impacts multiple organ systems in body, including cardiovascular system. This study first to characterize cardiac pathological changes mice under baseline conditions, offering novel insights into implications NPD. Using histological analysis, biochemical assays, and...
Background Accumulating evidence indicates that coronary microvascular dysfunction (CMD) caused by hypercholesterolemia can lead to myocardial ischemia, with or without obstructive atherosclerotic artery disease. However, the molecular pathways associated compromised function before development of ischemic injury remain poorly defined. In this study, we investigated effects on and integrity microcirculation in mice underlying mechanisms. Methods Results Mice were fed a hypercholesterolemic...
The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome is activated during atherogenesis, but how this occurs unclear. Here, we explored the mechanisms activating and regulating NLRP3 inflammasomes via acid sphingomyelinase (ASM)-ceramide signaling pathway. As a neointima formation model, partial left carotid ligations were performed on endothelial cell (EC)-specific ASM transgene mice (Smpd1
<title>Abstract</title> <bold>Background</bold> As a key inflammatory factor, the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome plays crucial role in neuroinflammation and progression of neurodegenerative diseases. Dysregulation NLRP3 signaling can trigger various responses brain, contributing to development diseases such as ischemic stroke, vascular dementia (VaD), Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS)....