A5102000239- Hippo pathway signaling and YAP/TAZ
- Inflammasome and immune disorders
- Retinoids in leukemia and cellular processes
- Congenital heart defects research
- Fluid Dynamics Simulations and Interactions
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Hereditary Neurological Disorders
- Angiogenesis and VEGF in Cancer
- Advanced biosensing and bioanalysis techniques
- Thermal Regulation in Medicine
- Macrophage Migration Inhibitory Factor
- Advanced Numerical Methods in Computational Mathematics
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Lattice Boltzmann Simulation Studies
- Extracellular vesicles in disease
University of Houston
2006-2025
University of Cincinnati Medical Center
2015-2017
University of Cincinnati
2014
Significance New blood vessel formation is a physiological process seen in development, as well wound healing and tumorigenesis. Although the of vasculature has been documented, little known about molecular mechanisms that regulate endothelial migration during vascular network formation. In this study, we identified critical role for Hippo effectors YAP TAZ regulation remodeling through controlling cell (EC) proliferation, filopodia formation, migration. We found striking cytoplasmic...
<title>Abstract</title> Niemann-Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disorder (LSD) caused by the deficiency of acid sphingomyelinase (ASMD), which encoded <italic>Smpd1</italic> gene. ASMD impacts multiple organ systems in body, including cardiovascular system. This study first to characterize cardiac pathological changes mice under baseline conditions, offering novel insights into implications NPD. Using histological analysis, biochemical assays, and...
Proper vascular formation is regulated by multiple signaling pathways. The endothelial growth factor (VEGF) promotes proliferation. Notch and its downstream targets act to lead cells toward an arterial fate through regulation of gene expression. However, the mechanisms how (ECs) in artery maintain their characteristics remain unclear. Here, we show that PRDM16 (positive regulatory domain-containing protein 16), a zinc finger transcription factor, expressed ECs, but not venous ECs developing...
Because adhesion of leukocytes to endothelial cells is the first step vascular-neuronal inflammation, inhibition and recruitment vascular will have a beneficial effect on neuroinflammatory diseases. In this study, we used pRNA bacteriophage phi29 DNA packaging motor construct novel RNA nanoparticle for specific targeting transferrin receptor (TfR) murine brain-derived (bEND5) deliver ICAM-1 siRNA. This (FRS-NPs) contained FB4 aptamer TfR siRNA moiety silencing intercellular molecule-1...
Abstract Background: As important components of the blood-brain barrier (BBB), brain endothelial cells (ECs) interact with pericytes, astrocytes, neurons, microglia and extracellular matrix in neurovascular unit to maintain central nerve system (CNS) homeostasis regulate neurological functions. Pathological changes endothelium plays an role progression ischemic stroke. The compromised BBB under stroke condition causes neuronal damage. However, pathophysiological mechanisms normal has not...