A5020728479- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Catalytic C–H Functionalization Methods
- Nanoparticle-Based Drug Delivery
- Synthesis and pharmacology of benzodiazepine derivatives
- Inhalation and Respiratory Drug Delivery
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Advanced Battery Technologies Research
- Oxidative Organic Chemistry Reactions
- Drug Transport and Resistance Mechanisms
- Fault Detection and Control Systems
- Advanced Drug Delivery Systems
- Chemical Synthesis and Analysis
- Zebrafish Biomedical Research Applications
- Aerospace Engineering and Energy Systems
- Icing and De-icing Technologies
- Venous Thromboembolism Diagnosis and Management
- Proteoglycans and glycosaminoglycans research
- Atrial Fibrillation Management and Outcomes
- Synthesis and Catalytic Reactions
- Cancer Treatment and Pharmacology
Nanchang Institute of Technology
2017-2024
Western New England University
2024
Husson University
2012-2022
Philippine Christian University
2022
Kerala Agricultural University
2018
Changzhou University
2017-2018
Mount Desert Island Biological Laboratory
2015
North China Electric Power University
2014
Texas Tech University Health Sciences Center
2004-2010
Texas Tech University
2004-2010
Pressure overload-induced hypertrophy is a key step leading to heart failure. The Ca(2+)-induced Ca(2+) release (CICR) process that governs cardiac contractility defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive. To examine intermolecular aspects of CICR during hypertrophy, we utilized loose-patch confocal imaging visualize signaling between single L-type channel (LCC) and ryanodine receptors (RyRs) aortic stenosis rat models compensated (CHT) decompensated...
Abstract Copper‐catalyzed cascade transformations of 2‐formylbenzonitrile and diaryliodonium salts were carried out to efficiently afford isoindolin‐1‐one scaffolds. The process proceeds through a copper‐catalyzed tandem C–H/N–H arylation, producing two different derivatives under reaction conditions. magnified image
Novel aptamer-functionalized polyethylene glycol–polylactic acid (PEG–PLA) (APP) micelles were developed with the objective to target transferrin receptor on brain endothelial cells. Flurbiprofen, a potential drug for therapeutic management of Alzheimer's disease (AD), was loaded into APP using co-solvent evaporation method. Results indicated that 9.03% (w/w) flurbiprofen entrapped in good retention capacity vitro. Targeting APPs investigated transferring receptor-expressing murine bEND5...
Diaryliodonium salts are characterized by poor atom economy with the formation of one equivalent an iodoarene as waste. We have developed atom‐economic iron‐catalyzed protocol for synthesis a variety thioethers diaryliodonium salts. Not only cyclic but also linear were found to perform well in reactions.
Abstract An efficient synthesis of a variety poly‐substituted isoindolinone derivatives via copper‐catalyzed three‐component cascade cyclization among 2‐formylbenzonitriles, alkyl aryl ketones/prop‐1‐en‐2‐ylbenzene and diaryliodonium salts is achieved. Various could be obtained in good to excellent yields. A concise dihydroisoindolo[2,1‐ ]quinolin‐11(5 H )‐ones have been achieved using this method. magnified image
A Cu-catalyzed three-component cascade cyclization among 2-formylbenzonitrile, cyclopropyl ketones, and diaryliodonium salts for the construction of fused isoindolin-1-one compounds is achieved. Pentacyclic isoindolinone derivatives could be obtained in moderate to good yields. The proposed mechanism involved a ring expansion ketones/formation N-acyliminium/hetero-[4 + 2]-cycloaddition process.
Currently low molecular weight heparin (LMWH) is administered as subcutaneous injection. This study sought to investigate the feasibility of LMWH an inhalable dry powder (DPI) formulation and evaluate interaction drug with lactose when used a carrier. The also compares extent pulmonary absorption that aerosolized aqueous solution.The formulations were prepared by mixing in solution followed lyophilization resulting solution. lyophilized preparation was then ground sieved. Physical...
A three-component cascade cyclization was developed to synthesize 2,3-diarylisoindolin-1-one by using 2-formylbenzonitrile, arenes, and diaryliodonium salts. The process underwent copper-catalyzed tandem C-N/C-C bond formation, producing isoindolin-1-one derivatives in good excellent yields.
One of the biggest challenges for small interfering RNAs (siRNAs) as therapeutic agents is their insufficient cellular delivery efficiency. We developed long circulating and cationic liposomes to improve cell uptake inhibitory effectiveness siRNA on expression vascular endothelial growth factor (VEGF) in cancer cells. SiRNA were obtained by polyelectrolyte complexation between negatively charged positively liposome prepared a hydration method. Gel electrophoresis was used evaluate loading...