A5082754460- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Computational Drug Discovery Methods
- Andrographolide Research and Applications
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- Epigenetics and DNA Methylation
- Biological and pharmacological studies of plants
- Body Composition Measurement Techniques
- Microbial infections and disease research
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Machine Learning in Bioinformatics
- Nutrition and Health in Aging
- Infection Control and Ventilation
- Autophagy in Disease and Therapy
- Bone health and osteoporosis research
- Cancer Cells and Metastasis
- Cancer therapeutics and mechanisms
Jilin University
2012-2025
Jilin Medical University
2021-2024
Fourth Affiliated Hospital of China Medical University
2021-2024
Dalian University of Technology
2022-2024
China Medical University
2021-2024
Chengdu University of Traditional Chinese Medicine
2022-2023
Guiyang Medical University
2022
Zhongshan Hospital
2021
Fudan University
2021
Zhongshan Hospital of Xiamen University
2021
Bufonis (VB), an animal drug called Chansu in China, is the product of secretion Bufo gargarizans Cantor or B. melanostictus Schneider. As a traditional Chinese medicine (TCM) for long time, it has been widely used treatment heart failure, ulcer, pain, and various cancers. Cinobufaginn (CNB), cardiotonic steroid bufalene lactone extracted from VB, effects detoxification, detumescence, analgesia.The present study aimed to define CNB on non-small-cell lung cancer (NSCLC) identify potential...
Yang-Yin-Qing-Fei-Tang (YYQFT) is a well-known traditional Chinese medicine used in the treatment of chronic obstructive pulmonary emphysema, bronchitis, cytomegaloviral pneumonia, but mechanisms are not clear. This study aimed to identify active components YYQFT and elucidate underlying mechanism on non-small cell lung cancer. First, was extracted with different solvents, then most effective extract determined by assessing their effects cancer growth. Second, several compounds from were...
In radiation oncology, ionizing is used to kill cancer cells, in other words, the induction of different types cell death. To investigate this cellular death and associated iron accumulation, transfer, release, participation after treatment was analyzed. We found that radiation-induced varied breast cells autophagy induced MDA-MB-231 BT549 (triple negative line) rather than MCF-7 zr-75 cells. Iron chelator deferoxamine (DFO), inhibitor 3MA, silencing autophagy-related genes ATG5, Beclin 1...
MSL1, a scaffold protein of the MSL histone acetyltransferase complex, is crucial for its structural integrity and enzymatic activity. While MSL1 highly expressed in various tumors, role tumor progression cell death remains unclear. Here, we provide evidence negative regulatory relationship between KCTD12 through biochemical assays knockdown/overexpression studies. Notably, colon cancer cells, ferroptosis inducer Erastin significantly suppressed expression, leading to upregulation. Moreover,...
Triptolide (TPL) is a diterpenoid triepoxide derived from the Chinese herb Tripterygium wilfordii and possesses anti-tumor activity against range of cancer cells.However, effect TPL on prostate cells its potential to overcome multidrug resistance (MDR) have not been explored.Therefore, in this study we used cell line DU145 as experimental model established DU145/ADM resistant adriamycin (ADM).Our results showed that inhibited proliferation induced cycle arrest apoptosis dose time dependent...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive and lethal malignancies worldwide. At present, underlying mechanisms ESCC development progression are poorly understood. Previous studies have demonstrated that homeodomain-interacting protein kinase-2 (HIPK2) serves an important role in cancer biology, particularly proliferation metastasis. However, HIPK2 cells remains unclear. In current study, expression specimens, adjacent non-cancerous tissues lines was assessed...
Exosomes may contain excess cellular components released by cells in response to harmful external stimuli maintain homeostasis. Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), can induce cell apoptosis, alter component expression levels, and stimulate exosome release. In this study, we examined whether exosomes from nucleus pulposus (NPCs) under inflammatory conditions could normal NP apoptosis rats its underlining mechanism.Exosomes were isolated TNF-α-treated NPCs used...
Abstract Dendrobium nobile and officinale as the main varieties of traditional Chinese medicine are widely used in clinic. The study aimed to systematically explore chemical constituents their antitumor effect D. by ultra-performance liquid chromatography coupled with ion trap time-of-flight mass spectrometry (UPLC-IT-TOF), network pharmacology cancer cell experiments. extract could significantly inhibit proliferation human lung A549 cells, liver HepG2 cells breast MCF-7 dose-dependent...
Gou Qi Zi (Lycium barbarum) is a traditional herbal medicine with antioxidative effects. Although has been used to prevent premature aging and in the treatment of non-small cell lung cancer (NSCLC), its mechanism action NSCLC remains unclear. The present study utilized network pharmacology assess potential NSCLC.The TCMSP, TCMID, SwissTargetPrediction, DrugBank, DisGeNET, GeneCards, OMIM TTD databases were searched for active components their therapeutic targets NSCLC. Protein-protein...
Identifying protein complexes from protein-protein interaction network is one of significant tasks in the postgenome era. Protein complexes, none which exceeds 10 size play an irreplaceable role life activities and are also a hotspot scientific research, such as PSD-95, CD44, PKM2 BRD4. And MIPS, CYC2008, SGD, Aloy TAP06 datasets, proportion small over 75%. But up to now, complex identification methods do not perform well field complexes.In this paper, we propose novel method, called BOPS....
A global understanding of ubiquitinated proteins in vivo is key to unraveling the biological significance ubiquitination. There are, however, a few effective screening methods for rapid analysis proteins. In current study, we designed cell-based cDNA expression array combined with cell imaging identification polyubiquitinated proteins, which normally accumulate form unique “dot” structure following inhibition ubiquitin proteasomes. The consisted 112 cDNAs encoding components major cellular...
<title>Abstract</title> MSL1, a scaffold protein of the histone acetyltransferase MSL complex, plays crucial role in structural integrity and enzyme activity complex. Although it has shown that MSL1 is highly expressed various primary tumor tissues, its molecular mechanism occurrence development tumors, as well impact on process cell death, are not yet fully understood. Herein, we presence evidence for first time from systematic biochemical assays knockdown/overexpression approaches arguing...
ABSTRACT Scientific and effective training is important to enhance the theoretical knowledge practical skills of clinical nurses in coronavirus disease 2019 (COVID‐19) prevention control (IPC), so as improve IPC capacity. The study aimed design implement a COVID‐19 program for based on ADDIE model, evaluate its application effects. This was pretest–posttest which 389 were recruited through convenience sampling. developed five stages model. Data analyzed using pared‐sample t test, McNemar's...
Impairment of vascular endothelial integrity is associated with various diseases. Our previous studies demonstrated that andrographolide critical to maintaining gastric homeostasis, as well regulating pathological remodeling. Potassium dehydroandrograpolide succinate (PDA), a derivative andrographolide, has been clinically used for the therapeutic treatment inflammatory This study aimed determine whether PDA promotes barrier repair in Partial ligation carotid artery ApoE-/- mice was evaluate...
Abstract Background: In August 2018, a large number of migratory birds died in Chifeng, Neimeng. We were entrusted by local animal disease prevention and control center to collect the bird epidemic materials their living environmental water, 2019, we stool water again. The bacterial communities materials, aquatic plants are profifiled high-throughput sequencing V3–V4 hypervariable region 16S rDNA gene. Results: found that dominant phylum between plant Proteobacteia, Bacteroidetes,...
Objective To investigate the effect of different subtypes fractionated doses on multidrug resistance in ovarian cancer cells.Methods The human cell lines SKOV3 and its drug-resistant subtype SKVCR were divided into four groups i.e., sham-irradiated, single dose (10 Gy),fractionated (2 Gy × 5 ) multi-fractionated (1 2 5).Cell sensitivity to vincristine(VCR),etoposide ( VP-16),pirarubicin (THP) cisplatin (DDP) was measured by MTT assay.Western blot applied detect expression P-gp after...