A5101822141- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Supramolecular Self-Assembly in Materials
- RNA modifications and cancer
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Lipid metabolism and disorders
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- Andrographolide Research and Applications
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Angiogenesis and VEGF in Cancer
Chengdu University of Traditional Chinese Medicine
2017-2024
Tianjin International Joint Academy of Biomedicine
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Institute of Hematology & Blood Diseases Hospital
2024
Sichuan University
2010-2023
Shandong University of Traditional Chinese Medicine
2023
Chongqing University
2019-2022
Army Medical University
2010-2020
Southwest Hospital
2020
Nankai University
2019
Twist is a critical epithelial-mesenchymal transition (EMT)-inducing transcription factor that increases expression of vimentin. How Twist1 regulates this remains unclear. Here, we report Cullin2 (Cul2) circular RNA to increase vimentin in EMT. bound the Cul2 promoter activate its and selectively promote (circ-10720), but not mRNA. circ-10720 positively correlated with Twist1, tumor malignance, poor prognosis hepatocellular carcinoma (HCC). promoted by increasing levels circ-10720, which can...
Triple-negative breast cancer is often aggressive and resistant to various therapies, especially corresponding targeted drugs. It shown that delivery of chemotherapeutic drugs tumor sites could enhance treatment outcome against triple-negative cancer. In this study, we exploited the active tumor-targeting capability macrophages by loading doxorubicin-carrying liposomes on their surfaces via biotin–avidin interactions. Compared with conventional liposomes, macrophage–liposome (MA-Lip) system...
Abstract Quaking (QKI) is an alternative splicing factor that can regulate circRNA formation in the progression of epithelial–mesenchymal transition, but mechanism remains unclear. High expression QKI correlated with short survival time, metastasis, and high clinical stage pathology grade hepatocellular carcinoma (HCC). Here we report transcription gene was activated by Yin-Yang 1 (YY1)/p65/p300 complex, which YY1 bound to super-enhancer promoter QKI, p65 combined promoter, p300 served as a...
Bufonis (VB), an animal drug called Chansu in China, is the product of secretion Bufo gargarizans Cantor or B. melanostictus Schneider. As a traditional Chinese medicine (TCM) for long time, it has been widely used treatment heart failure, ulcer, pain, and various cancers. Cinobufaginn (CNB), cardiotonic steroid bufalene lactone extracted from VB, effects detoxification, detumescence, analgesia.The present study aimed to define CNB on non-small-cell lung cancer (NSCLC) identify potential...
Disturbed intestinal microbiota has been implicated in the inflammatory microenvironment of colon, which usually results ulcerative colitis (UC). Given limitations these drugs, it is important to explore alternative means protecting gut health from UC. This study aimed investigate potential polysaccharides as beneficial nutrients regulation microbiota, determines colon.
Saikosaponin-a and -d, two naturally occurring compounds derived from Bupleurum radix, have been shown to exert anti-cancer activity in several cancer cell lines. However, the effect of combination saikosaponins with chemotherapeutic drugs has never addressed. Thus, we investigated whether these chemosensitization on cisplatin-induced cytotoxicity. Two cervical lines, HeLa Siha, an ovarian line, SKOV3, a non-small lung A549, were treated or cisplatin individually combination. Cell death was...
BackgroundHypoxia commonly occurs in solid tumors. The hypoxia the center of tumors considerably decreases chemosensitivity tumor cells and induces epithelial–mesenchymal transition (EMT) as well drug resistance antitumor drugs.MethodsHere, effects salidroside (Sal) combined with platinum drugs on human hepatocellular carcinoma were examined vitro vivo. We investigated Sal by inhibiting explained its mechanism growth.FindingsThe results showed that co-administration reverses suppressed...
Abstract Diol-type ginsenosides, such as protopanaxadiol (PPD), exhibit antioxidation, anti-inflammation, and antitumor effects. However, the effect of these ginsenosides mechanism PPD remain unclear. In this work, effects several derivatives, including PPD, Rg5, Rg3, Rh2, Rh3, were evaluated in five different cancer cell lines. demonstrated best inhibitory on proliferation migration lines, especially hepatocellular carcinoma (HCC) Therefore, action HCC cells was elucidated. inhibited...
Abstract Protein therapy offers promising prospects for the treatment of various important diseases, thus it is highly desirable to develop a robust carrier that can deliver active proteins into cells. The development novel protein delivery platform based on self‐assembly multiarmed amphiphilic cyclodextrins (CDEH) reported. CDEH self‐assemble nanoparticles in aqueous solution and achieve superior encapsulation (loading capacity > 30% w/w) simply by mixing with without introducing any...
Osteosarcoma is usually resistant to immunotherapy and, thus primarily relies on surgical resection and high-dosage chemotherapy. Unfortunately, less invasive or toxic therapies such as photothermal therapy (PTT) chemodynamic (CDT) generally failed show satisfactory outcomes. Adequate multimodal with proper safety profiles may provide better solutions for osteosarcoma. Herein, a simple nanocomposite that synergistically combines CDT, PTT, chemotherapy osteosarcoma treatment was fabricated....
Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly miR-106a relieved its inhibition Large Tumor Suppressor Kinases 1 2, thereby suppressing Yes-Associated Protein signaling pathway. Under both normal hypoxic conditions, ectopic expression...
The combination of tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) with other agents has been recognized as a promising strategy to overcome TRAIL resistance in cancer cells. Baicalin (5, 6‑dihydroxy‑7‑o‑glucuronide flavone) is flavonoid from the root medicinal herb Scutellaria baicalensis Georgi, which reported exert antioxidant, anti‑inflammatory, antiviral and anticancer activities vitro. However, effect baicalin on TRAIL‑induced cytotoxicity not previously reported. In...
Size expansion can effectively improve tumor accumulation of nanocarriers where precise control is required. A dual-responsive nanocarrier stimulated by both endogenous pH and exogenous heat stimuli change its size. Herein, a nanoparticle composed poly(N,N-diethyl acrylamide) (PDEAA) poly(2-(diisopropylamino) ethyl methacrylate) (PDPA) developed. The antitumor drug celastrol (CLT) the photosensitizer indocyanine green (ICG) are then loaded in it to form CIPP. ICG generates under...
Abstract Protein therapy has the potential to revolutionize medicine, but delivery of multiple proteins is challenging because it requires development a strategy that enables different be combined together and transported not only into cells, also desired cell compartments, such as nucleus. Here, an efficient intranuclear protein nanoplatform based on modified ribonuclease A (RNase A) tuned self‐assembly presented. RNase bioreversibly with adamantane functionalized wind chime‐like lysine...
Pathological vascular remodeling is a hallmark of various diseases. Smooth muscle cell (SMC) phenotypic switching plays pivotal role during pathological remodeling. The mechanism how to regulate SMC still needs be defined. This study aims investigate the effect Andrographolide, key principle isolated from Andrographis paniculate, on and its underlying mechanism. A C57/BL6 mouse left carotid artery complete ligation model rat SMCs were used determine whether Andrographolide critical in...
Subcellular organelle targeted transport is of great significance for accurately delivering drugs to active sites better pharmacological effects, but there are still a lot challenges due problems. In addition, the killing effect one kind drug on cells limited. Therefore, it necessary develop multifunctional nanoplatform that can co-deliver synergistic therapeutic agents. Here, we prepare simple amphiphilic nanocarrier (LC) with rapid endosomal escape ability nucleus-selective delivery...
Acute kidney injury (AKI) is a complication of wide range serious illnesses for which there still no better therapeutic agent. We demonstrated that M-18C has favorable inhibitory effect on monoacylglycerol lipase (MAGL), and several studies have nerve inflammation could be effectively alleviated by inhibiting MAGL, suggesting good anti-inflammatory activity. In this study, we investigated the LPS-induced acute (AKI), both in vivo vitro, using liquid chromatography-mass spectrometry (LC-MS),...
The purpose of the present study was to investigate effect bufadienolides on A‑375 melanoma cell line, and delineate underlying mechanism. A Cell Counting Kit‑8 assay used determine viability cells, flow cytometry evaluate apoptosis. Western blot analysis expression levels proteins involved in AKT pathway that are associated with apoptosis autophagy. results demonstrated reduced cells a dose‑ time‑dependent manner. Following treatment bufadienolides, exhibited clear properties were...
Abstract The aim of this study is to investigate the therapeutic role Tanshinone II A, a key integrant from salvia miltiorrhiza, against pathological vascular remodeling. Completed ligation mouse left common carotid arteries animal model and rat smooth muscle cells used A in regulating remodeling through hematoxylin eosin staining, immunohistochemistry immunofluorescence adenovirus infection, real time PCR western blotting. Our data demonstrated that treatment suppresses injury-induced...
Breast cancer was the leading cause of newly diagnosed cases tumors in 2020, ranking as second highest female death. Chemotherapy remains conventional treatment choice for breast most clinical cases. However, it is often accompanied by a poor prognosis and severe side effects, resulting from an insufficient accumulation drug at tumor sites unsystematic distribution across body. Inspired fact that cells overexpress integrin α2β1 on surface, we designed constructed targeting DGEA-modified...