A5004427581- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Carbohydrate Chemistry and Synthesis
- Sirtuins and Resveratrol in Medicine
- Monoclonal and Polyclonal Antibodies Research
- Protein Tyrosine Phosphatases
- Autophagy in Disease and Therapy
- Seaweed-derived Bioactive Compounds
- Ubiquitin and proteasome pathways
- Calcium signaling and nucleotide metabolism
- Enzyme Production and Characterization
- Peptidase Inhibition and Analysis
- Genomics, phytochemicals, and oxidative stress
- Acute Kidney Injury Research
- Bacteriophages and microbial interactions
- Adenosine and Purinergic Signaling
- Toxin Mechanisms and Immunotoxins
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- FOXO transcription factor regulation
- Cancer Mechanisms and Therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Bioactive Natural Diterpenoids Research
- Nanofabrication and Lithography Techniques
- Nanoplatforms for cancer theranostics
Qingdao University of Science and Technology
2023-2025
Ocean University of China
2014-2024
Qingdao National Laboratory for Marine Science and Technology
2018-2024
Stanford University
2024
Laoshan Laboratory
2023-2024
China Geological Survey
2022
Ministry of Education of the People's Republic of China
2018
GlcNAcylation, a dynamic posttranslational modification, is involved in wide range of biological processes and some human diseases. Although there emerging evidence that tumor-associated proteins are modified by the role GlcNAcylation tumor progression remains unclear. Here, we show enhances migration/invasion breast cancer cells vitro lung metastasis vivo. The decrease cell surface E-cadherin molecular mechanism underlying GlcNAcylation-induced metastasis. p120 beta-catenin, but not...
Bacterial exopolysaccharides have always been suggested to play crucial roles in the bacterial initial adhesion and development of complex architecture later stages biofilm formation. However, Escherichia coli group II capsular polysaccharide was characterized exert broad-spectrum inhibition activity. In this study, we firstly reported that a exopolysaccharide (A101) not only inhibits formation many bacteria but also disrupts established some strains. A101 with an average molecular weight up...
Abstract SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in regulation of metabolism, stress responses, genome stability, ageing. As sensor, deacetylase activity significantly increased during stresses, but molecular mechanisms are not yet fully clear. Here, we show that dynamically modified with O-GlcNAc at Ser 549 its carboxy-terminal region, which directly increases both vitro vivo. The O-GlcNAcylation elevated genotoxic, oxidative, metabolic...
Abstract Telomere length is an important biomarker of organismal aging and cellular replicative potential, but existing measurement methods are limited in resolution accuracy. Here, we deploy digital telomere (DTM) by nanopore sequencing to understand how distributions human change with age disease. We measure attrition de novo elongation up 30 bp genetically defined populations cells, blood cells from healthy donors patients genetic defects maintenance. find that accompanied a progressive...
Abstract Protein S -nitrosylation, the redox-based posttranslational modification of a cysteine thiol by attachment nitric oxide (NO) group, is responsible for variety signaling effects. Dysregulation -nitrosylation may be directly linked to cancer apoptotic resistance and therapy outcomes, emphasizing importance in cancer. Peroxiredoxin-2 (Prdx2), an antioxidant enzyme, plays important role protection cells from oxidative radical damage caused hydrogen dioxide (H 2 O ), which potential...
Non-alcoholic steatohepatitis (NASH) is a primary cause of cirrhosis and hepatocellular carcinoma. Unfortunately, there no approved drug treatment for NASH. AMP-activated kinase (AMPK) an important metabolic sensor whole-body regulator. It has been proposed that AMPK activators could be used treating diseases such as obesity, type 2 diabetes In this study, we screened marine natural compound library by monitoring activity found potent activator, candidusin A (CHNQD-0803). Further studies...
TROP-2, a tumor-associated antigen, has been implicated in the progression of various epithelial tumors. Due to its favorable expression profile, TROP-2 emerged as promising target for antibody–drug conjugates (ADCs) based anti-tumor therapies. Although ADCs have shown efficacy cancer treatment, their application solid tumors is hindered by high molecular weight, poor tumor penetration, and release cytotoxic molecules. Therefore, recombinant immunotoxin was developed on shark-derived...
Agarases are generally classified into glycoside hydrolase families 16, 50, and 86 found to degrade agarose frequently generate neoagarobiose, neoagarotetraose, or neoagarohexaose as the main products. In this study we have cloned a novel endo-type beta-agarase gene, agaB, from marine Pseudoalteromonas sp. CY24. The agarase encoded by agaB gene has no significant sequence similarity with any known proteins including all hydrolases. It degrades neoagarooctaose neoagarodecaose end Based on...
Abstract Background Lipocalin 2, an iron binding protein, is abnormally expressed in some malignant human cancers and may play important role tumor metastasis. However, the roles of lipocalin 2 breast cancer formation metastasis have not been clearly shown. This study aimed to investigate Methods was overexpressed metastatic 4T1 murine mammary cells. The effects overexpression on malignancy cells were examined using cell proliferation assay, migration invasion soft agar assay vitro . Tumor...
Abstract Background Gangliosides are sialic acid containing glycosphingolipids that ubiquitously distributed on vertebrate plasma membranes. GM3, a precursor for most of the more complex ganglioside species, is synthesized by GM3 synthase. Although total levels significantly higher in breast tumor tissue than normal mammary tissue, roles played gangliosides cancer formation and metastasis not clear. Methods To investigate development, synthase was silenced highly metastatic 4T1 cells...
Abstract Pancreatic cancer is a highly aggressive cancer, and primarily treated with gemcitabine, increasing resistance. SIRT6 as member of sirtuin family plays important roles in lifespan diverse diseases, such diabetes, inflammation neurodegenerative diseases. Considering the role cytoprotective effect, it might be potential anticancer drug target, associated resistance to therapy. However, very few inhibitors have been reported. Here, we reported discovery pyrrole-pyridinimidazole...
Land use/Land cover (LULC) change seriously affects ecosystem services and functions. In order to maintain ecological security orderly social development, habitat quality assessment based on is worth exploring. Based multi-source land use data Google remote sensing from 1985 2017, transfer matrix index were used study change, spatial-temporal evolution of quality, driving factors influencing in Sanjiang Plain. The results showed that changed significantly especially paddy increased by...
O-GlcNAc is an O-linked ?-N-acetylglucosamine moiety attached to the side-chain hydroxyl of a serine or threonine residue in numerous cytoplasmic and nuclear proteins. In this study, we detected level prostate, liver pancreatic cancer tissues, found that global modification also known as O-GlcNAcylation, specifically increased prostate tissues compared corresponding adjacent tissues. addition, O-GlcNAcylation cells not benign prostatic hyperplasia (BPH) epithelial cells. enhanced...
Eugenol is a naturally occurring compound that present in variety of plants and has previous been demonstrated to exert number bioactivities. However, the potential effects on cellular protection against oxidative stress remain poorly understood. In study, HEK‑293 cells mouse fibroblast cell line NIH‑3T3 were used as models explore eugenol H<sub>2</sub>O<sub>2</sub>‑induced damage. Among three natural compounds tested, namely eugenol, methyleugenol acetyleugenol, was found increase...
Introduction O-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues intracellular proteins in eukaryotic cells, which generated by the sole O-GlcNAc transferase (OGT) and removed O-GlcNAcase (OGA). Thousands proteins, that are involved various physiological pathological processes, have been found to be O-GlcNAcylated. However, due lack favorable tools, studies OGT were impeded. Immunoglobulin new antigen receptor (IgNAR) derived from shark attractive...
The transcription factor NRF2 plays a significant role in regulating genes that protect cells from oxidative damage. O-GlcNAc modification, type of posttranslational is crucial for cellular response to stress. Although the involvement both and maintaining redox balance promoting cancer malignancy has been demonstrated, potential mechanisms remain elusive.