A5079930022- Monoclonal and Polyclonal Antibodies Research
- Polysaccharides and Plant Cell Walls
- Fungal Biology and Applications
- Polysaccharides Composition and Applications
- Ginseng Biological Effects and Applications
- Silymarin and Mushroom Poisoning
- Phytochemicals and Antioxidant Activities
- Microbial Natural Products and Biosynthesis
- Exercise and Physiological Responses
- Galectins and Cancer Biology
- CAR-T cell therapy research
- Edible Oils Quality and Analysis
- Bee Products Chemical Analysis
- Phytochemistry and biological activity of medicinal plants
- Helicobacter pylori-related gastroenterology studies
- Plant and fungal interactions
- Pharmacological Effects of Natural Compounds
- Phytochemical Studies and Bioactivities
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Natural Compound Pharmacology Studies
- Cholesterol and Lipid Metabolism
- Cholinesterase and Neurodegenerative Diseases
Shandong Provincial Hospital
2025
Ocean University of China
2023-2025
Shandong University
2025
Qingdao University of Science and Technology
2024
Qingdao National Laboratory for Marine Science and Technology
2023
Shandong University of Traditional Chinese Medicine
2017-2019
TROP-2, a tumor-associated antigen, has been implicated in the progression of various epithelial tumors. Due to its favorable expression profile, TROP-2 emerged as promising target for antibody–drug conjugates (ADCs) based anti-tumor therapies. Although ADCs have shown efficacy cancer treatment, their application solid tumors is hindered by high molecular weight, poor tumor penetration, and release cytotoxic molecules. Therefore, recombinant immunotoxin was developed on shark-derived...
Introduction O-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues intracellular proteins in eukaryotic cells, which generated by the sole O-GlcNAc transferase (OGT) and removed O-GlcNAcase (OGA). Thousands proteins, that are involved various physiological pathological processes, have been found to be O-GlcNAcylated. However, due lack favorable tools, studies OGT were impeded. Immunoglobulin new antigen receptor (IgNAR) derived from shark attractive...
Helicobacter pylori (H. pylori) is recognized as a pathogen associated with several gastrointestinal diseases. The current treatments exhibit numerous drawbacks, including antibiotic resistance. H. can adhere to and colonize the gastric mucosa through adhesin A (HpaA), antibodies against HpaA may be an effective therapeutic approach. variable domain of immunoglobulin new antigen receptor (VNAR) novel type single-domain antibody small size, good stability, easy manufacturability. This study...
Different endophytes isolated from the seeds of Sophora flavescens were tested for their ability to produce matrine production. Response surface methodology (RSM) was applied optimize medium components endophytic fungus. Results indicated that endophyte Aspergillus terreus had matrine. The single factor tests demonstrated potato starch best carbon source and combination peptone NH4NO3 optimal nitrogen A. terreus. model RSM predicted gain maximal production at 20.67 μg/L, when 160.68 g/L,...
This review presents the chemical constituents and pharmacological actions of Silybum marianum. These include flavonolignans, fatty acids, phenolics other constituents. Furthermore, flavonolignans silymarin isosilychristin, silychristin, silydianin, silybin A, B, isosilybin etc. Pharmacological a well curative effect on non-alcoholic steatohepatitis, UV damage, varieties cancers, diabetes. In addition, its anti-inflammatory, anti-depression more actions. paper will enable marianum lay...
Background: Liver fibrosis is a serious health problem worldwide. Literature sources indicated that liver was reversible and an effective treatment would probably reverse the process. However, there no satisfied agent in clinical practice to pathological process yet. Oxidative stress inflammation are important mechanisms propagating CCl4-induced injury. Objective: To evaluate protective effect of Silybum marianum seeds oil (SMSO) on oxidative hepatic injury inflammatory responses. Methods:...
Diabetes mellitus (DM) is a common endocrine and metabolic disease caused by protein fat metabolism disorders as the main clinical manifestation due to relative or absolute deficiency of insulin secretion in body. Despite significant prevention treatment efforts, number people with DM still increasing. A safe effective resource prevent treat urgently needed. In recent years, many reports have indicated that medicinal mushrooms hypoglycemic effect. Among them, Coprinus comatus has great...