A5100369508- Nanoplatforms for cancer theranostics
- Advanced Photocatalysis Techniques
- Liquid Crystal Research Advancements
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Electrocatalysts for Energy Conversion
- Advanced Nanomaterials in Catalysis
- Inhalation and Respiratory Drug Delivery
- Copper-based nanomaterials and applications
- Graphene research and applications
- Quantum Dots Synthesis And Properties
- Silk-based biomaterials and applications
- Metallic Glasses and Amorphous Alloys
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Phase-change materials and chalcogenides
- Enzyme Catalysis and Immobilization
- Catalytic Processes in Materials Science
- Immunotherapy and Immune Responses
- Fuel Cells and Related Materials
- 2D Materials and Applications
- Electrospun Nanofibers in Biomedical Applications
- Material Dynamics and Properties
- Electromagnetic wave absorption materials
- Drug Solubulity and Delivery Systems
Yunnan Academy of Agricultural Sciences
2024-2025
Northwest A&F University
2025
Academy of Military Medical Sciences
2025
Chongqing University
2016-2024
Second People Hospital of Hunan
2024
Zhejiang Normal University
2024
China Tobacco
2024
Shanghai University
2023-2024
Sun Yat-sen University
2023-2024
Zhejiang Gongshang University
2024
Although several artificial nanotherapeutics have been approved for practical treatment of metastatic breast cancer, their inefficient therapeutic outcomes, serious adverse effects, and high cost mass production remain crucial challenges. Herein, we developed an alternative strategy to specifically trigger apoptosis tumors inhibit lung metastasis by using natural nanovehicles from tea flowers (TFENs). These had desirable particle sizes (131 nm), exosome-like morphology, negative zeta...
Staphylococcus aureus survival inside phagocytes is considered to provide a reservoir of bacteria that are relatively protected from antibiotics, thus enabling long-term colonization the host and explaining clinical failures relapses after antibiotic therapy.The objective this study was develop nanovesicle using exosomes loaded with linezolid overcome intracellular infections by pathogenic bacteria.Exosomes were collected culture supernatants RAW 264.7 cells. Their size distribution zeta...
Flocculation or restacking of different kinds two-dimensional (2D) nanosheets into heterostructure nanocomposites is interest for the development high-performance electrode materials and catalysts. However, lacking a molecular-scale control on layer sequence hinders enhancement electrochemical activity. Herein, we conducted electrostatic layer-by-layer (LbL) assembly, employing oxide (e.g., MnO2, RuO2.1, reduced graphene (rGO)) layered double hydroxide (LDH) NiFe-based LDH) to explore series...
The specific in situ generation and activation of therapeutic agents with high spatiotemporal precision is expected to revolutionize cancer treatment. Here, we develop an intelligent nanoplatform (termed as NP-Cu), which constructed by assembling photosensitizer chlorin e6 (Ce6), hypoxia-responsive prodrug banoxantrone (AQ4N) clickable dibenzocyclooctyne (DIBO) functionalized lysine (D-K), cyclen-Cu2+ complex, for improving combination anticancer therapy. Cyclen-Cu2+ complex-induced...
Pyroptosis is an inflammation-dependent and self-cascade amplifying type of programmed cell death, serving as effective means for activating the local immune response improving anticancer efficacy. As effector pyroptosis, gasdermin-E (GSDME) silenced in most tumor cells. The gene silencing can be reversed by DNA demethylation, but systemic side effects toxicity chemotherapeutic agents are inevitable. In this work, inhaled poly(lactic-co-glycolic acid) (PLGA) porous microspheres loaded with...
Semiconductor photocatalyzed energy production and environment treatment have received a lot of attention. Mn–Cd–S solid solutions (MnxCd1−xS) with tunable band structure, suitable redox capacity, visible light response is recognized as one the most promising photocatalysts for practical applications. However, low separation efficiency photogenerated carriers sluggish reaction kinetics restricts its photocatalytic activity. This review discusses advantages drawbacks MnxCd1−xS photocatalysis...
Overexploitation of antibiotics increases the emergence multidrug-resistant agents (MDRAs), which may potentially cause a global crisis with severe health consequences. Hence, there is great demand for next-generation antibacterial platforms based on antibiotic-free strategies or targeted therapies to mitigate MDRAs. Herein, an all-in-one hollow nanoworm (A-Fe/AuAg@PDA) developed core comprising citrate-capped Au–Ag nanoparticles (Cit-AuAg NPs) loaded Fe2O3 and l-arginine (L-Arg)-modified...
The oxidative stress amplifier CaO 2 /ICG@ZIF-8 was constructed by loading and ICG onto ZIF-8, achieving efficient photodynamic photothermal synergistic therapy -mediated cascades of oxygen production glutathione consumption.
The mucosal barrier remains a major in the pulmonary drug delivery system, as mucociliary clearance airway accelerates removal of inhaled nanoparticles (NPs). Herein, we designed and developed inhalable Pluronic F127-modified silk fibroin NPs loading with quercetin (marked QR-SF (PF127) NPs), aiming to solve mucus improve cancer therapeutic effect QR. PF127 coating on SF could attenuate interaction between mucin proteins, thus facilitating diffusion SF(PF127) layer. had particle sizes...
Porous PLGA microparticle for the coencapsulation of doxorubicin and miR-519c was successfully constructed through water–oil–water emulsion solvent evaporation method, using ammonium bicarbonate as a porogen. It has been characterized with high porous surface, adaptive aerodynamic diameter (<10 μm), favorable drug loading, sustained release profile. The supernatant exhibited higher inhibition cell proliferation than those from microparticles harboring single component (doxorubicin or...
Combinational cancer therapy offers a promising strategy to overcome the limitations of single-drug treatment, including limited therapeutic efficacy, serious side effects, and low survival rate. Injectable silk fibroin (SF) hydrogel has emerged as an effective platform for localized treatment. Herein, hydrophilic SF (HSF) was extracted from regenerated self-assembled into within 2–6 h. The obtained HSF showed obvious viscoelasticity, thixotropic behavior, self-healing performance....
To the Editor: Hepatocellular carcinoma (HCC) is a prominent contributor to cancer-related mortality on global scale. While therapeutic approaches, such as surgical resection, liver transplantation, and radiofrequency ablation, have demonstrated effectiveness for specific patient populations, 5-year overall survival (OS) rate in HCC discouragingly low, estimated at only 18%. This unfavorable outcome can primarily be attributed high recurrence metastasis rates.[1] Therefore, there an urgent...
This paper first introduces the raw materials of alkali-activated cementitious materials, analyzes mechanical properties concrete, namely compressive strength, flexural splitting tensile elastic modulus and stress-strain curve, steel fiber concrete. The results show that strength fly ash concrete can be improved by adding appropriate amount slag. There is a nonlinear relationship between slag descending section curve relatively steep, which similar to high-strength Alkali-activated has high...