A5043546888- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Enzyme Catalysis and Immobilization
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Microbial Metabolic Engineering and Bioproduction
- Catalysis for Biomass Conversion
- Click Chemistry and Applications
- Inhalation and Respiratory Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Metal-Organic Frameworks: Synthesis and Applications
- Proteoglycans and glycosaminoglycans research
- Cancer-related Molecular Pathways
- Advanced Drug Delivery Systems
- Cyclopropane Reaction Mechanisms
- Antimicrobial agents and applications
- Steroid Chemistry and Biochemistry
- Freezing and Crystallization Processes
- Berberine and alkaloids research
Jilin University
2016-2025
Jilin Medical University
2011-2025
Northwest A&F University
2023-2024
State Council of the People's Republic of China
2019
First Hospital of Jilin University
2017-2019
Ministry of Education of the People's Republic of China
2018
Tufts University
2017
Changchun Institute of Applied Chemistry
2010-2016
Chinese Academy of Sciences
2010-2016
Shenyang Ligong University
2007
Two types of carbon dots (C dots) exhibiting respective excitation-independent blue emission and excitation-dependent full-color emissions have been synthesized via a mild one-pot process from chloroform diethylamine. This new bottom-up synthetic strategy leads to highly stable crystalline C with tunable surface functionalities in high reproducibility. By detailed characterization comparison the two dots, it is proved concretely that functional groups, such as C═O C═N, can efficiently...
Enhancing the activity and stability of enzymes improving their reusability are critical challenges in field enzyme immobilization. Here we report a facile efficient biomimetic mineralization to embed thermophilic lipase QLM zeolite imidazolate framework-8 (ZIF-8). Systematic characterization indicated that entrapment molecules was successfully achieved during crystal growth ZIF-8 with an loading ∼72.2 ± 1.88 mg/g lipase@ZIF-8, could facilitate construction framework building blocks. Then...
Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Herein, we develop a polypeptide-based block ionomer complex formed by anionic methoxy poly(ethylene glycol)-b-poly(L-glutamic acid) (mPEG-b-PLG) and cationic anticancer drug doxorubicin hydrochloride (DOX·HCl) for NSCLC treatment. This spontaneously self-assembled into spherical nanoparticles (NPs) in aqueous solutions via electrostatic interaction hydrophobic stack, with high loading efficiency...
Near-infrared light is an attractive stimulus due to its noninvasive and deep tissue penetration. Particularly, NIR utilized for cancer thermotherapy on-demand release of drugs by the disruption delivery carriers. Here we have prepared a novel NIR-responsive DNA-hybrid-gated nanocarrier based on mesoporous silica-coated Cu1.8S nanoparticles. nanoparticles, possessing high photothermal conversion efficiency under 980 nm laser, were chosen as agents. The silica structure could be used drug...
In rheumatoid arthritis (RA), insufficient apoptosis of macrophages and excessive generation pro-inflammatory cytokines are intimately connected, accelerating the development disease. Here, a fluorinated polyamidoamine dendrimer (FP) is used to deliver miR-23b reduce inflammation by triggering as well inhibiting inflammatory response in macrophages. Following intravenous injection FP/miR-23b nanoparticles experimental RA models, show therapeutic efficacy with inhibition response, reduced...
Hydroxylation of C25 C–H bonds (referring to sterols) is great importance in vivo for metabolizing sterols and vitamin Ds. The biocatalytic hydroxylation restricted by the selectivity activity enzymes due inertness these bulky compounds. Herein, we employed fungal unspecific peroxygenase from Agrocybe aegerita (AaeUPO) as catalyst develop efficient selective AaeUPO variants through protein engineering. After three rounds evolution using semirational design, 2 variants, G195A/G241V/G318V...
Abstract CDDP is loaded into methoxypoly(ethylene glycol)‐ block‐ poly( L ‐glutamic acid) (mPEG ‐b‐ PLG), and a combination with iRGD applied for NSCLC chemotherapy. The CDDP‐loaded micelles show sustained cisplatin release in PBS, dose‐ time‐dependent inhibition to HeLa A549 cell proliferation, no apparent hemolysis activities. In vivo studies using subcutaneous xenograft models (A549), both free an evident anti‐tumor effect. However, the toxicity of significantly reduced cases...
Abstract High‐throughput synthesis of well‐defined, ultrahigh molecular weight (UHMW) polymers by green approaches is highly desirable but remains unexplored. We report the creation an atom‐economic enzymatic cascade catalysis, consisting formate oxidase (FOx) and horseradish peroxidase (HRP), that enables high‐throughput reversible addition‐fragmentation chain transfer (RAFT) UHMW at volumes down to 50 μL. FOx transforms formic acid, a C 1 substrate, oxygen CO 2 H O , respectively. can...
An enzyme mimic harboring iron porphyrin (DhHP-6) embedded in zeolite imidazolate framework-8 (ZIF-8) was constructed through a biomimetic mineralization approach to obtain composite DhHP-6@ZIF-8. The then used as catalyst the atom transfer radical polymerization (ATRP) of poly(ethylene glycol) methyl ether methacrylate (PEGMA500) which poly(PEGMA500) could be synthesized with monomer conversion 76.1% and Mn 45 900 g/mol, stronger than that obtained when using free DhHP-6 catalyst. More...
Biomaterial-associated infections caused by bacterial contamination and the subsequent formation of biofilms on surfaces are challenges faced our healthcare system. In this work, povidone-iodine-functionalized fluorinated copolymers with stable antibacterial, antibiofilm, antifouling activities were designed prepared a two-step synthesis. First, series poly(hexafluorobutyl methacrylate-co-N-vinyl-2-pyrrolidone), i.e., P(HFBMA-NVP), synthesized radical copolymerization at different feed...
A simple uric acid detection method is successfully developed through the integration of urate oxidase (UOx) and PCN-222(Fe) with peroxidase-like activity.
Poly(ethylene terephthalate) (PET) is a manufactured plastic broadly available, whereas improper disposal of PET waste has become serious burden on the environment. Leaf-branch compost cutinase (LCC) one most powerful and promising hydrolases, its mutant LCCICCG shows high catalytic activity excellent thermal stability. However, low binding affinity with been found to dramatically limit further industrial application. Herein, TrCBM CfCBM were rationally selected from CAZy database construct...