A5101932747- Silymarin and Mushroom Poisoning
- Bioinformatics and Genomic Networks
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Enzyme Catalysis and Immobilization
- Berberine and alkaloids research
- Synthesis and bioactivity of alkaloids
- Neurological Disease Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Plant Parasitism and Resistance
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Plant Pathogenic Bacteria Studies
- Tumors and Oncological Cases
- Hedgehog Signaling Pathway Studies
- Lanthanide and Transition Metal Complexes
- Transgenic Plants and Applications
- Nuclear Receptors and Signaling
- Luminescence Properties of Advanced Materials
- Polyamine Metabolism and Applications
- Insect-Plant Interactions and Control
- Acute Ischemic Stroke Management
- Plant-Microbe Interactions and Immunity
Jilin University of Chemical Technology
2011-2025
Huizhou University
2024
Guangzhou University of Chinese Medicine
2024
Shantou Central Hospital
2020-2021
Chinese Academy of Sciences
2014
Changchun Institute of Applied Chemistry
2014
Chinese People 's Liberation Army No. 85 Hospital
2013
Jilin University
2011-2012
Jinan Stomatological Hospital
2010
Shandong University
2005
The hedgehog pathway plays a critical role in the development of foregut. However, primary esophageal cancers is not well studied. Here, we report that elevated expression target genes occurs 14 22 cancers. signaling activation associated with tumor subtypes, stages, or differentiation. While sonic (Shh) transcript localized to tissue, Gli1 and PTCH1 observed both stroma. We discovered 4 squamous cell carcinomas, which overexpress Shh, have genomic amplification Shh gene. Treatment cancer...
The NaYF<sub>4</sub>:Yb, Er@mSiO<sub>2</sub>@Fe<sub>3</sub>O<sub>4</sub>-PEG nanoparticles combining dual-modal diagnostic methods and magnetically targeted anti-tumor therapy were investigated.
Nanoparticles have been explored as nonviral gene carriers for years because of the simplicity surface modification and lack immune response. Lanthanide-based upconversion nanoparticles (UCNPs) are becoming attractive candidates biomedical applications in virtue their unique optical properties multimodality imaging ability. Here, we report a UCNPs-based structure with polyethylenimine coating both efficient transfection trimodality imaging. Cytotoxicity tests demonstrated that exhibited...
Breast cancer (BC) is a common malignancy worldwide. It has been reported that long non-coding RNA (lncRNA) HOX transcript antisense (HOTAIR) abnormally expressed in BC. However, the role of HOTAIR BC worth further discussion. This study aims to clarify function and molecular mechanism BC.Quantitative real-time polymerase chain reaction (qRT-PCR) was employed determine expression HOTAIR, microRNA (miR)-601 zinc finger E-box binding homeobox 1 (ZEB1). Cell counting kit-8 (CCK-8) transwell...
Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cell growth through mitogenic signaling pathways. However, whether it can human pancreatic carcinoma what are the underlying mechanisms is still not well elucidated. Here, we evaluated inhibitory proliferation effects of Silibinin examined modulates cycle apoptosis. Our results indicate that effectively inhibited AsPC-1, BxPC-3 Panc-1 cells' caused induced a...
Gastric cancer (GC) is the 3rd leading cause of tumor‑associated mortality worldwide. The efficacy paclitaxel, a frequently used GC chemotherapeutic agent, hindered due to drug resistance, dose‑induced toxicity and adverse side effects. Silibinin, an active compound widely consumed dietary supplement, milk thistle extract, has recently been demonstrated have strong antitumor in human cell model. Thus, enhance treatment, present study evaluated whether silibinin exerted synergistic...
Abstract This study aimed to identify modules associated with breast cancer (BC) development by constructing a gene co-expression network, and mining hub genes that may serve as markers of invasive (IBC). We downloaded 2 expression datasets from the Gene Expression Omnibus (GEO) database, used weighted network analysis (WGCNA) dynamically changes in normal tissues, ductal carcinoma situ (DCIS) IBC tissues. Modules highly correlated BC were carried out functional enrichment for annotation,...
Silibinin, a flavonoid compound, has shown to be of chemopreventive potential against many cancers. However, its efficacy gastric cancer not been well elucidated. Here, we assessed the activity Silibinin on apoptosis and cell‐cycle arrest in human cells culture system using SGC‐7901 as model. treatment could inhibit cell growth cause prominent G 2 phase dose‐ time‐dependent manner. In mechanistic studies, decreased protein level p34cdc2, which might possible molecular mechanism inhibition...
Rice stem borer, Chilo suppressalis , is a common and major serious pest of rice, maize, wheat crops across Asia, Europe, Oceania countries. Its sex pheromone consists three analogously compounds, i.e., (Z)-hexadec-11-enal ( 1 ), (Z)-octadec-13-enal 2 Z )-hexadec-9-enal 3 as long-chain aliphatic internal cis -alkenyl aldehydes. In order to perform an economic widespread control management rice versatile efficient synthetic strategy required. A synthesis using route for -alkenals with high...
Ischemic stroke (IS) is a significant global health issue, causing high rates of morbidity, mortality, and disability. Since conventional Diagnosis methods for IS have several shortcomings. It critical to create new models in order enhance existing approaches.
Solid state fermentation (SSF) was used to cultivate Bacillus marinus on particles of polyurethane foam impregnated with suitable medium for immobilization bound intracellular lipase within biomass support (BSPs). Compared the free dried cell, activity immobilized cell in BSPs increased from 680.2 Unit per gram cells 968.5U/g cells. This is first report cultivation solid culture BSPs.