A5100437947- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Tumors and Oncological Cases
- Synthetic Organic Chemistry Methods
- Phytoestrogen effects and research
- Boron Compounds in Chemistry
- Quinazolinone synthesis and applications
- Neuropeptides and Animal Physiology
- Protein Degradation and Inhibitors
- Nitric Oxide and Endothelin Effects
- Genetic and Kidney Cyst Diseases
- Prostate Cancer Treatment and Research
- Natural Antidiabetic Agents Studies
- Psidium guajava Extracts and Applications
- Axon Guidance and Neuronal Signaling
- Phytochemistry and biological activities of Ficus species
- Oral and Maxillofacial Pathology
- Hippo pathway signaling and YAP/TAZ
- Analytical Chemistry and Chromatography
- Biochemical Analysis and Sensing Techniques
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Renal and related cancers
- Receptor Mechanisms and Signaling
Shenyang Pharmaceutical University
2017-2024
Southern Medical University
2022
Air Force Medical University
2020
Indiana University Health
2012
Indiana University – Purdue University Indianapolis
2012
The University of Texas Medical Branch at Galveston
2004-2005
The hedgehog pathway plays a critical role in the development of prostate. However, prostate cancer is not clear. Prostate second most prevalent cause death American men. Therefore, identification novel therapeutic targets for has significant clinical implications. Here we report that activation occurs frequently advanced human cancer. We find high levels target genes, PTCH1 and hedgehog-interacting protein (HIP), are detected over 70% tumors with Gleason scores 8–10, but only 22% 3–6....
The hedgehog pathway plays a critical role in the development of foregut. Recent studies indicate that activation occurs stomach and other gastrointestinal cancers. However, association with tumor stage, differentiation subtype is not well documented. Here, we report our findings elevated expression target genes human patched gene 1 (PTCH1) or Gli1 63 99 primary gastric Activation associated poorly differentiated more aggressive tumors. sonic (Shh) transcript localized to cancer tissue,...
The hedgehog pathway plays a critical role in the development of foregut. However, primary esophageal cancers is not well studied. Here, we report that elevated expression target genes occurs 14 22 cancers. signaling activation associated with tumor subtypes, stages, or differentiation. While sonic (Shh) transcript localized to tissue, Gli1 and PTCH1 observed both stroma. We discovered 4 squamous cell carcinomas, which overexpress Shh, have genomic amplification Shh gene. Treatment cancer...
Abstract Objectives Gli1 + cells have received extensive attention in tissue homeostasis and injury mobilization. The aim of this study was to investigate whether respond force contribute bone remodelling. Materials methods We established orthodontic tooth movement (OTM) model assess the response for mechanical force. transgenic mice were utilized label inhibit cells, respectively. Additionally, that conditional ablate Yes‐associated protein (Yap) applied present study. remodelling analysed....
Two series of benzamides compounds bearing piperidine groups were synthesized and the Gli-luc luciferase activity was screened by Gys-luc gene detection method. Compound 5q showed promising inhibition hedgehog (Hh) signaling pathway. To further verify whether Hh inhibitory activities target are derived from their to Smoothened (Smo) receptor, with good potency evaluated in a fluorescence competitive displacement assays, results Smo these correlated well inhibition, which suggested that...
Abstract Development of subtype‐selective drugs for G protein‐coupled receptors poses a significant challenge due to high similarity between subtypes, as exemplified by the three β‐adrenergic (βARs). The β 3 AR agonists show promise treating overactive bladder or preterm birth, but their potential is hindered off‐target activation 1 and 2 AR. Interestingly, several β‐blockers, which are antagonists ARs ARs, have been reported exhibit agonist activity at However, molecular mechanism remains...