A5101968259- Kruppel-like factors research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- RNA Interference and Gene Delivery
- Numerical methods for differential equations
- Biometric Identification and Security
- Face recognition and analysis
- Statistical Methods and Bayesian Inference
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Numerical methods in engineering
- Biosensors and Analytical Detection
- ATP Synthase and ATPases Research
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Transplantation: Methods and Outcomes
- Identification and Quantification in Food
- Metabolism, Diabetes, and Cancer
Chongqing Medical University
2021-2023
Chengdu University of Traditional Chinese Medicine
2023
Guangdong Polytechnic of Science and Technology
2023
Shandong Normal University
2022
Nanjing Medical University
2022
Jilin University of Chemical Technology
2019
Southwest University
2019
Today, it has become a hot issue in cancer research to make precise prognostic prediction for breast patients, which can not only effectively avoid overtreatment and medical resources waste, but also provide scientific basis help staff patients family members right decisions. As well known, is partly inherited disease with various important biological markers, especially the gene expression profile data clinical data. Therefore, accuracy of model be improved by integrating In this paper, we...
Abstract The problem that the dimension of facial features is too large does exist with Deep learning face recognition. This paper proposes a recognition algorithm based on SVM combined VGG network model extracting features, which can not only accurately extract but also reduce feature dimensions and avoid irrelevant to participate in calculation. Firstly, VGG-16 obtained by training data set, used for extraction, top this, principal component analysis method (PCA) dimensionality reduction,...
Glucosamine 6-phosphate N-acetyltransferase (GNPNAT1) is a crucial enzyme involving hexosamine biosynthesis pathway and upregulated in breast cancer (BRCA). However, its biological function mechanism on patients BRCA have not been investigated.In this study, the differential expression of GNPNAT1 was analyzed between tissues normal using Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO) database, which validated by quantitative real-time polymerase chain reaction, Western...
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate complex, which inhibits its activity. Inhibiting complex tricarboxylic acid cycle and reprogramming of tumor cell metabolism to glycolysis, plays an important role in progression. This study aims elucidate how PDK1 promotes breast cancer We found that was highly expressed tissues, knockdown reduced proliferation, migration, tumorigenicity cells inhibited HIF-1α (hypoxia-inducible factor 1α) pathway. Further investigation...
Abstract Breast cancer is the most common malignancy among women worldwide. Functional studies have demonstrated that miRNA dysregulation in many cases of cancer, which miRNAs act as either oncogenes or tumor suppressor. Here we report miR-345-3p generally upregulated breast tissues and cell lines. Overexpression inhibition revealed its capacity regulating proliferation invasion cells. Further research identified protein phosphatase 2 catalytic subunit alpha (PPP2CA), a suppressor AKT...
Abstract Ewing’s sarcoma (ES) represents a rare yet exceedingly aggressive neoplasm that poses significant health risk to the pediatric and adolescent population. The clinical outcomes for individuals with relapsed or refractory ES are notably adverse, primarily attributed constrained therapeutic alternatives available. Despite advancements in field, molecular pathology-driven strategies have achieve definitive reduction mortality rates associated ES. Consequently, there exists an imperative...
Abstract Pyruvate dehydrogenase kinase 1 (PDK1) is a widely known glycolytic enzyme, and some evidence showed that PDK1 promoted breast cancer by multiple approaches. However, very few lncRNAs have been identified to be associated with in previous research. In this study, we found lncRNA sprouty4‐intron transcript (SPRY4‐IT1) was regulated correlation analysis, upregulated SPRY4‐IT1 remarkably cells, as interacted the nucleus significantly enhanced stability of SRPY4‐IT1. Furthermore, highly...
By using the central difference scheme to discretize Riemann-Liouville time fractional derivatives and finite point method establish discrete algebraic equation systems, a meshless is proposed for numerical analysis of Cable equation. The error estimation derived in detail. Numerical results verify efficiency convergence confirm theoretical results.
<p>Supplementary Figure S2 shows SUR1 regulated the growth of NSCLCs, and expression levels phosphorylated p70S6K KLF4.</p>
<p>Supplementary Figure S7 shows histone acetylation was not involved in p70S6K induced downregulation of KLF4.</p>
<p>Supplementary Figure S6 shows knockdown of KLF4 expression promoted cell growth, EMT, and migration.</p>
<p>Supplementary Figure S4 shows KATP channels openers inhibited the growth of NSCLCs.</p>
<p>Supplementary Figure S3 shows glibenclamide downregulated cyclin D1 expression and p70S6K signaling pathway in NSCLCs.</p>
<p>Supplementary Figure S5 shows the proteomics analysis of p70S6K binding proteins in HEK293T cells.</p>
<p>Supplementary Figure S3 shows glibenclamide downregulated cyclin D1 expression and p70S6K signaling pathway in NSCLCs.</p>
<p>Supplementary Figure S5 shows the proteomics analysis of p70S6K binding proteins in HEK293T cells.</p>
<p>Supplementary Figure S7 shows histone acetylation was not involved in p70S6K induced downregulation of KLF4.</p>