A5100461132- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Barrier Structure and Function Studies
- RNA modifications and cancer
- Bone and Joint Diseases
- Peroxisome Proliferator-Activated Receptors
- Gestational Diabetes Research and Management
- Health disparities and outcomes
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Stress and Burnout Research
- Occupational Health and Performance
- Maternal Mental Health During Pregnancy and Postpartum
- RNA Research and Splicing
- Resilience and Mental Health
- Epigenetics and DNA Methylation
Chongqing Medical University
2022-2025
Chongqing Public Health Medical Center
2023-2025
Glucosamine 6-phosphate N-acetyltransferase (GNPNAT1) is a crucial enzyme involving hexosamine biosynthesis pathway and upregulated in breast cancer (BRCA). However, its biological function mechanism on patients BRCA have not been investigated.In this study, the differential expression of GNPNAT1 was analyzed between tissues normal using Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO) database, which validated by quantitative real-time polymerase chain reaction, Western...
The differentiation fate of bone marrow mesenchymal stem cells (BMSCs) affects the progression steroid-induced osteonecrosis femoral head (SONFH). We find that lncRNA DGCR5 encodes a 102-amino acid polypeptide, RIP (Rac1 inactivated peptide), which promotes adipogenic BMSCs and aggravates SONFH. RIP, instead DGCR5, binds to N-terminal motif RAC1, inactivates RAC1/PAK1 cascade, resulting in decreased Ser675 phosphorylation β-catenin. Ultimately, nuclear localization β-catenin decreases,...
Abstract Pyruvate dehydrogenase kinase 1 (PDK1) is a widely known glycolytic enzyme, and some evidence showed that PDK1 promoted breast cancer by multiple approaches. However, very few lncRNAs have been identified to be associated with in previous research. In this study, we found lncRNA sprouty4‐intron transcript (SPRY4‐IT1) was regulated correlation analysis, upregulated SPRY4‐IT1 remarkably cells, as interacted the nucleus significantly enhanced stability of SRPY4‐IT1. Furthermore, highly...
Depressive symptoms (DS) can erode physical and mental health, social support (SS) is considered a buffer for DS promoter improving coping recovery abilities. However, there almost no research on the mediating role of negative (NC) in SS DS, especially among firefighters. A cross-sectional survey was conducted firefighters Chongqing, China, valid data 407 were collected through questionnaires distributed WeChat platform 2020. Statistical Product Service Solutions (SPSS) 26.0 used descriptive...
Breast cancer (BCa) is the most common malignancy in women and claudin-low breast (CL-BCa) a newly identified BCa subtype characterized by low expression of claudin 3&4&7. However, hub genes associated with recruitment immune cells into CL-BCa were rarely described. This study aimed at exploring differentially expressed tumor-infiltrating multi-approach bioinformatics analysis. The top 200 screened METABRIC dataset; PPI network was constructed using STRING Cytoscape; analyzed...