Conventional dual-chamber pacing maintains atrioventricular synchrony but results in high percentages of ventricular pacing, which causes desynchronization and has been linked to an increased risk atrial fibrillation patients with sinus-node disease.We randomly assigned 1065 disease, intact conduction, a normal QRS interval receive conventional (535 patients) or minimal the use new pacemaker features designed promote preserve prevent (530 patients). The primary end point was time persistent...

Circulating tumor cells (CTCs) are the seeds of distant metastases malignant tumors and associated with malignancy risk metastasis. However, undergo epithelial-mesenchymal transition (EMT) during metastasis, leading to emergence different types CTCs. Real-time dynamic molecular functional typing CTCs is necessary precisely guide personalized treatment. Most CTC detection systems based on epithelial markers that may fail detect EMT Therefore, it clinically important identify new types. In...

The synthesis of compounds having quaternary carbon centers through a catalytic stereo- and regioselective difunctionalization 2-substituted 1,3-dienes remains elusive. Here, we present dual Co/photoredox-catalyzed cascade approach that addresses this challenge using modular vinyl cyclic carbonates functioning as masked 2-aryl-1,3-diene surrogates. latter species are conveniently prepared in situ converted into nucleophilic Co(allyl) intermediates intercepted by aldehydes to afford...

Since October 2023, a significant outbreak of Mycoplasma Pneumoniae Pneumonia (MPP) has been observed in children northern China. Chinese health authorities have attributed this epidemiological to immune debt resulting from the relaxation coronavirus disease 2019 (COVID-19) control measures. This study described features pneumoniae (MP) prevalence and developed straightforward prediction model differentiate between MPP viral pneumonia children. The infection rate MP notably increased 8.12...

The traditional production of long‐chain organic esters like isobutyl isobutyrate (BIBE) suffers from severe problems due to the homogenous catalyst in process and complex system thermodynamics. In this work, an innovative bifunctional deep eutectic solvent (DES) is introduced, playing as both reaction extraction solvent, intensify esterification process. DES was formed by imidazole (Im) p ‐toluenesulfonic acid (PTSA), which for first time found acid–base tunable, represented weak basic...

A general access to chiral dihydroindole derivatives in high yields is achieved by C–H functionalization a highly site- and enantioselective cascade reaction of propargyl diazoacetates. Highly site-selective intramolecular C(sp3)–H bond insertions are realized catalyst control. Sterically demanding dirhodium carboxylates, optimized with Rh2(S-BTPCP)4, favor insertion into 1° bonds regioselectivities reaching >95:5 (1° > 2° benzylic) >90% ee. With Rh2(S-TBPTTL)4, preferential 3° occurs due...

Abstract Staphylococcus aureus or methicillin-resistant (MRSA) is an important issue associated with significant morbidity and mortality well known as a predominant pathogen causing bloodstream infection (BSIs) globally. To estimate the antibiotic resistance molecular characteristics of S. BSIs in Shanghai, 120 isolates (20 each year) from patients 2013 to 2018 were randomly selected enrolled this study. Fifty-three (44.2%) MRSA determined, no isolate was found resistant vancomycin,...

Abstract To test diagnostic accuracy of changes in thickness (TH) and cross-sectional area (CSA) muscle ultrasound for diagnosis intensive care unit acquired weakness (ICU-AW). Fully conscious patients were subjected to ultrasonography including measuring the TH CSA biceps brachii (BB) muscle, vastus intermedius (VI) rectus femoris (RF) muscles over time. 37 underwent on admission day, day 4, 7, 10 after ICU admission, Among them, 24 found have ICW-AW. Changes RF right side showed remarkably...

Urbanization accelerates habitat fragmentation and leads to the decline of biodiversity in cities. Urban greenway landscapes provide not only social functions but also important ecological services. In this study, taxonomic richness, abundance, diversity, distribution soil meso- microfauna were investigated three different urban assess their environmental quality. that had a richer tree species composition, higher deciduous ratios, wider greenspace, moderate temperature moisture, lower bulk...

We report a user-friendly approach for the decarboxylative formation of stereodefined and complex tri- tetra-substituted olefins from vinyl cyclic carbonates amines as radical precursors. The protocol relies on easy photo-initiated α-amino-radical followed by addition onto double bond substrate resulting in sequence involving carbonate ring-opening, relay, CO

Volatile organic compounds (VOCs) play a key role in plant communication with other organisms the natural environment. However, regulatory of phytohormone ethylene volatile production plants remains unclear. In this study, we demonstrated that application an precursor and amplification signaling make rice more attractive to brown planthopper (BPH) females for feeding oviposition. A combination transcriptome VOCs analyses indicated overexpression OsEIL1, master transcription factor pathway,...

Rapid access to highly functional allylated BCP synthons can be achieved with good selectivity and yield through a radical, three-component reaction (3CR) regime using various combinations of radical precursors vinyl-appended heterocycles acting as versatile modular precursors. This practical process combines mild operating conditions, wide scope partners, the ability diversify functionalized allylic scaffolds further allyl other groups synthetic branching points. The developed protocol...

The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has emerged as a serious public health problem worldwide, and the data on fecal carriage CRE strains in hospitalized children remain limited. This study aimed to investigate molecular characteristics intestinal colonization Shandong, China. A retrospective was conducted from August November 2023. Antimicrobial susceptibility testing performed by broth microdilution method. Carbapenemase genes, drug resistance plasmid replicon...

Objective: To analyze the differences in pediatric CT radiation dose and scanning parameter Settings between children's specialized hospitals general hospitals, to provide reference for optimization strategy of dose. Methods: From July August 2022, a stratified sampling method was used select 7 comprehensive 2 Tianjin, on-site survey conducted collect data head, chest, abdomen pelvic examinations these hospitals. The Wilcoxon rank sum test CTDI(vol) DLP same age group examination site among...

A Ni-mediated decarboxylative silylation of alkynyl cyclic carbonates used as versatile propargylic surrogates is reported affording a wide range highly substituted 2,3- and 3,4-allenol products in good yields. The formal cross-coupling between tentative intermediate Ni(allenyl) the silyl reagent was further extended to enantiospecific conversions providing access chiral allene synthons. This protocol marks first Ni-catalyzed proceeding through an SN2' manifold.