A5008803333- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Fibroblast Growth Factor Research
- Cardiovascular Health and Disease Prevention
- interferon and immune responses
- RNA Research and Splicing
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Alcohol Consumption and Health Effects
- RNA Interference and Gene Delivery
- Advanced Glycation End Products research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced biosensing and bioanalysis techniques
- Kruppel-like factors research
- Colorectal Cancer Treatments and Studies
- Natural Antidiabetic Agents Studies
- Parathyroid Disorders and Treatments
- Cardiovascular Health and Risk Factors
- Livestock and Poultry Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Sun Yat-sen University
2010-2025
Shanghai Sixth People's Hospital
2023-2025
Shanghai Jiao Tong University
2017-2025
Sun Yat-sen Memorial Hospital
2010-2025
Fuyang Second People's Hospital
2023-2024
Anhui Medical University
2023-2024
Zhumadian Central Hospital
2024
Jiangxi Agricultural University
2021-2024
Ruijin Hospital
2017-2022
Shanghai Institute of Hematology
2019-2022
Abstract Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary physicians (PCPs), particularly in low-resource settings. Here, bridge the gaps, we developed an integrated image–language system (DeepDR-LLM), combining large language model (LLM module) image-based deep learning (DeepDR-Transformer), provide individualized management recommendations PCPs. In retrospective evaluation, LLM module demonstrated...
MicroRNA-122 (miR-122), a pivotal liver-specific miRNA, is frequently repressed in hepatocellular carcinoma (HCC) and associated with poor prognosis. Long non-coding RNA (lncRNA) HOTAIR has been proved to function as an oncogene multiple cancers including HCC. However, the relationship between miR-122 HCC remains largely unknown.We investigated of cell models xenograft mouse model. The regulatory network was further detected following overexpression or knockdown HOTAIR. DNA methylation...
OBJECTIVE Uncertainty remains regarding the predictive value of various glycemic measures as they relate to risk diabetes and its complications. Using cutoffs recommended by American Diabetes Association’s 2010 criteria, we determined associations fasting plasma glucose (FPG), 2-h postload (2h-PG), HbA1c with outcomes. RESEARCH DESIGN AND METHODS Baseline medical history, FPG, 2h-PG, were obtained from a population-based cohort 193,846 adults aged ≥40 years in China during 2011–2012. A...
Abstract Ewing’s sarcoma (ES) is a rare and highly aggressive malignant tumor arising from bone soft tissue. Suffering intractable or recurrent diseases, the patients’ therapy options are very limited. It extremely urgent to identify novel potential therapeutic targets for ES put them into use in clinical settings. In present study, high-throughput screening of small molecular pharmacy library was performed. The killing effect Aurora kinase A (AURKA) inhibitor TCS7010 cells identified, AURKA...
Abstract Aims Fibroblast growth factor (FGF) 23 is a bone‐derived phosphaturic hormone that participates in the regulation of mineral metabolism and development chronic kidney disease. This study aimed to investigate association between FGF23 diabetic disease (DKD) community‐based prospective cohort. Materials Methods Of 7230 individuals who completed 4.6‐year follow‐up survey, 1614 with diabetes at baseline were included this study. Baseline serum levels measured by enzyme‐linked...
Hepatitis C Virus core protein (HCVc) plays important roles in the development of intrahepatic cholangiocarcinoma (ICC). MicroRNAs (miRNAs) contribute to tumor progression by interacting with downstream target genes. However, regulation and role miRNAs HCV‐related (HCV‐ICC) is poorly understood. In this study, we found that miR‐124 was down‐regulated HCV‐ICC induction DNMT1 HCVc mediated suppression miR‐124. Over‐expression suppressed cell migration invasion vitro, reduced levels SMYD3 genes...
Long noncoding RNAs (lncRNAs) are important regulators in cancer progression. Deregulation of the lncRNA taurine upregulated gene 1 (TUG1) predicts poor prognosis and is implicated development several cancers. In this study, we investigated role TUG1 pathogenesis intrahepatic cholangiocarcinoma (ICC). We found that ICC samples, which correlates with adverse clinical pathological characteristics. Knockdown inhibited proliferation, motility, invasiveness cultured cells, decreased tumor burden...
Long non-coding RNA HOX transcript antisense (HOTAIR) has been demonstrated to exhibit oncogenic activity in several types of cancer, including hepatocellular carcinoma (HCC). However, the association between HOTAIR and HCC multidrug resistance remains uncertain. The present study aimed investigate role chemoresistance; it was found that knockdown expression Huh7 cells resulted decreased cell proliferation increased chemosensitivity cisplatin. Furthermore, levels ATP binding cassette...
Abstract Aims Management of blood glucose fluctuation is essential for diabetes. Exercise a key therapeutic strategy diabetes patients, although little known about determinants glycemic response to exercise training. We aimed investigate the effect combined aerobic and resistance training on in type 2 patients explore predictors exercise‐induced response. Materials Methods Fifty sedentary were randomly assigned control or group. Participants group maintained lifestyle weeks, those...
Highlights•RBP-4, FGF-21, adiponectin, and osteocalcin enhance risk prediction for SLD•Adiponectin shows the best predictive performance SLD•Elevated FGF-21 RBP-4 emphasize metabolic alcohol management, respectivelySummaryThe effectiveness of established biomarkers non-alcoholic fatty liver disease (NAFLD) within updated framework steatotic (SLD) remains uncertain. This cohort study examines association four biomarkers—retinol-binding protein 4 (RBP-4), fibroblast growth factor 21 (FGF-21),...
BackgroundThe relationship between fibroblast growth factor 21 (FGF21) and sweet taste perception preference in type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate this examine the neural responses of T2DM patients high-calorie (HCS) food pictures, further exploring its correlation with FGF21 levels. MethodsWe assessed 40 41 controls using classical scales. Subsequently, 11 HCS pictures were examined functional magnetic resonance imaging. levels measured...
The long noncoding RNA, homeobox transcript antisense RNA (Hotair), has been demonstrated to have an important role in regulating various biological processes cancers, including hepatocellular carcinoma (HCC). However, the importance of Hotair HCC proliferation and cell cycle progression remains be elucidated. In present study, knockdown HOTAIR expression by interference inhibited induced G0/G1 arrest Huh7 cells. addition, levels CCND1 mRNA its cyclin D1 protein product were reduced cells...
Increasing evidence has been accumulated indicating the important role of epigenetic regulation in tumor genesis. Previously, we observed that transfection hepatitis C virus core (HCVc) protein led to malignant transformation normal biliary cells, and suppressor gene RASSF1A was downregulated many hilar cholangiocarcinoma patients by hypermethylation promoter region. In present study, found SET MYND domain-containing 3 (SMYD3), a novel histone methyltransferase, overexpressed especially...
Distinctive structures called crypts harbor intestinal epithelial stem cells (IESCs) which generate progenitor and terminally differentiated in the epithelium. Mammalian IESCs their daughter require participation of DNA methylation transcription factor Sox9 for proliferation differentiation. However, association between this process remains elusive. The small db/db mice was detected via combining methylated immunoprecipitation with microarray hybridization. promoter validated using bisulfite...
Long noncoding RNAs (lncRNAs) are key regulators of cancer initiation and progression. In this study, we investigated the clinical value functional role LncRNA DQ786243 (LncDQ) in pathogenesis hepatocellular carcinoma (HCC). To investigate expression level LncDQ HCC, performed quantitative real-time PCR using total RNA extracted from HCC tumor tissues their matched non-neoplastic counterparts, as well serum patients healthy volunteers. The correlation with clinicopathologic features...
Abstract Background The dazzling phenotypic characteristics of male Indian peafowl (Pavo cristatus) are attractive both to the female species and humans. However, little is known about evolution phenotype phylogeny these birds at whole-genome level. So far, there no reports regarding genetic mechanism formation leucism plumage in this variant peafowl. Results A draft genome was assembled, with a size 1.05 Gb (the sequencing depth 362×), contig scaffold N50 were up 6.2 11.4 Mb, respectively....
HCV Core plays a role in the development of hepatocellular carcinoma. Aberrant expression NANOG has been observed many types human malignancies. However, relationship between and not clarified. In this study, we found that is capable up‐regulating expression. Core‐induced was accompanied by enforced phosphorylated stat3 protein attenuated inhibition phosphorylation. ChIP showed directly binds to promoter. resulted enhanced cell growth cycle progression. Knockdown blocked at G0/G1 phases...
This study examined whether resting heart rate (RHR) was associated with metabolic syndrome (MetS) and the 10-year predicted risk of cardiovascular disease in a Chinese population.The associations RHR MetS atherosclerotic diseases (ASCVD) cross-sectional conducted Shanghai, China (n = 9486).Compared individuals lowest quintile (≤71 b.p.m.), those highest (≥91 b.p.m.) had higher prevalence (21.2% vs 32.6%, respectively; P < 0.001). Logistic regression analyses showed that...
The short-video application TikTok shows great potential for disseminating health information. We assessed the content, sources, and quality of information in videos related to nonalcoholic fatty liver disease (NAFLD) on TikTok. Our study aims identify upload characteristic NAFLD further evaluate factors video quality. investigated top 100 analyzed characteristics these videos. Evaluate using DISCERN tool Global Quality Score (GQS). In addition, correlation between is studied. terms majority...