A5102007433- Gastric Cancer Management and Outcomes
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer-related gene regulation
- Genetic diversity and population structure
- Gut microbiota and health
- Digestive system and related health
- Cancer-related Molecular Pathways
- Eosinophilic Esophagitis
- Microbial Natural Products and Biosynthesis
- Urban Heat Island Mitigation
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Colorectal Cancer Screening and Detection
- Radiopharmaceutical Chemistry and Applications
- Cardiomyopathy and Myosin Studies
Sun Yat-sen University
2015-2025
Sun Yat-sen Memorial Hospital
2014-2025
Chinese Academy of Fishery Sciences
2022-2025
Washington University in St. Louis
2014-2024
Tianjin Medical University General Hospital
2018-2024
Ministry of Agriculture and Rural Affairs
2024
Huashan Hospital
2023
Fudan University
2023
China Medical University
2015-2022
Liaoning Cancer Hospital & Institute
2020-2022
Berberine and metformin, both established pharmaceutical agents with herbal origins, have incidental beneficial effects on multiple diseases, including diabetes. These been speculated to occur via the gut microbiome. In this study, we administered either berberine or metformin db/db mice investigated changes in body weight, food intake, blood glucose levels. Fresh stool samples were analyzed using 16 s rDNA high-throughput sequencing evaluate Short-chain fatty acids (SCFA) quantified gas...
Abstract Background Impaired intestinal barrier structure and function have been validated as an important pathogenic process in type 2 diabetes mellitus (T2DM). Gut dysbiosis is thought to be the critical factor diabetic pathogenesis. As most abundant commensal bacteria, Faecalibacterium prausnitzii (F. prausnitzii) play roles gut homeostasis. The microbial anti‐inflammatory molecule (MAM), F. metabolite, has potential inflammatory bowel disease (IBD). Thus, we aimed explore mechanism of...
The increased migration and invasion of oral squamous cell carcinoma cells are key events in the development metastasis to lymph nodes distant organs. Although chemokine receptor CXCR4 its ligand, stromal cell-derived factor-1α, have been found play an important role tumor invasion, precise potential underlying mechanisms remain largely unknown. In this study, we showed that knockdown significantly decreased Tca8113 accompanied with reduction MMP-9 MMP-13 expression. Inhibition ligand...
Abstract Conditioned medium from mesenchymal stem cells (MSC-CM) may represent a promising alternative to MSCs transplantation, however, the low concentrations of growth factors in non-activated MSC-CM hamper its clinical application. Recent data indicated that paracrine potential could be enhanced by inflammatory factors. Herein, we pre-activated bone-marrow-derived under radiation-induced condition (MSC IEC-6(IR) ) and investigated evidence mechanism for differential effects on intestinal...
N6‑methyladenosine (m6A) RNA modification maintained by N6‑methyltransferases and demethylases is involved in multiple biological functions. Methyltransferase like 3 (METTL3) a major N6‑methyltransferase. However, the role of METTL3 its installed m6A colorectal tumorigenesis remains to be fully elucidated. highly expressed as indicated cancer samples TCGA Oncomine databases, implying potential colon tumorigenesis. SW480 cell line with stable knockout (METTL3‑KO) was generated using...
Gastric intestinal metaplasia (GIM) is a risk factor for development of intestinal-type gastric cancer. We aimed to assess the usefulness confocal laser endomicroscopy (CLE) in diagnosing GIM.28 patients with known GIM underwent CLE, and CLE criteria diagnosis were developed. In addition, 53 consecutive or suspected prospectively evaluated.GIM was identified if any following three features present an image field: goblet cells, columnar absorptive cells brush border, villiform foveolar...
// Ti-Dong Shan 1 , Ji-Hao Xu Tao Yu Jie-Yao Li Lin-Na Zhao 3 Hui Ouyang Su Luo Xi-Ji Lu Can-Ze Huang Qiu-Shen Lan 2 Wa Zhong Qi-Kui Chen Department of Gastroenterology and Guangdong Provincial Key Laboratory Malignant Tumor Epigenetics Gene Regulation, Sun Yat-Sen Memorial Hospital, University, Guangzhou, 510120, People's Republic China General Surgery, Gastroenterology, the First Affiliated Guangzhou University Traditional Chinese Medicine, 510504, Correspondence to: Yu, e-mail:...
The Pacific abalone Haliotis discus hannai originated in cold waters and is an economically important aquaculture shellfish China. Our goal was to clarify the current status of genetic structure In this study, eighteen polymorphic EST-SSR loci were successfully developed based on hemolymph transcriptome data abalone, thirteen highly selected for variation analysis six populations collected. results showed that average number observed alleles 8.0769 (RC)-11.3848 (DQ) each population. DQ, NH,...
Clinically, human glioblastoma (GBM) may develop de novo or from a low-grade glioma (secondary GBM), and molecular alterations in the two pathways differ. This study examined status of Survivin expression apoptosis 30 primary 26 secondary GBMs. Our results show that cytoplasmic positivity was significantly (P<0.001) more frequent GBMs (83%) than (46%). In addition, an inverse correlation cytoplasmc with GBM apoptotic index, positive association between size tumours were observed. These...
Proliferative change and intestinal barrier dysfunction in mucosa of diabetes have been described, but the differentiation characteristics epithelial cells (IECs) mechanisms IECs development remain unclear. To explore constitution patterns function, diabetic mouse model was induced by streptozotocin. Tight junctions between were significantly damaged serum level D-lactate raised mice (P < 0.05). The expression Zo1 Ocln small intestine lower, while markers for absorptive cell (SI) Paneth...
<b>Background and study aims:</b> Gastric intestinal metaplasia (GIM) is associated with a risk for development of intestinal-type gastric cancer. This aimed to compare the diagnostic yield GIM from confocal laser endomicroscopy (CLE) white light endoscopy (WLE). <b>Patients methods:</b> In prospective, double-blind, randomized study, patients were randomly assigned receive either CLE targeted biopsies (group A) or WLE standard biopsy protocol B). <b>Results:</b> A total 168 finally analyzed...
See also: Commentaire de travail X. J. Xie et al., pp. 87Endoscopy 2011; 43(02): 172-173DOI: 10.1055/s-0031-1291812
Oxidative stress is significant in numerous types of cancer. Tobacco smoke, an important risk factor for oral squamous cell carcinoma (OSCC), able to generate reactive oxygen species (ROS) and cause oxidative DNA damage. Superoxide dismutase (SOD) endogenous antioxidant enzyme that critical limiting the burden effectively. The purpose this study was investigate effects mitochondrial SOD2 Cu/Zn SOD1 gene polymorphisms on susceptibility clinicopathological characteristics OSCC, as well...