A5006584092- Cardiovascular and exercise physiology
- Molecular Biology Techniques and Applications
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Heart Rate Variability and Autonomic Control
- HER2/EGFR in Cancer Research
- Diabetes Management and Research
- MicroRNA in disease regulation
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- High Altitude and Hypoxia
- Intracranial Aneurysms: Treatment and Complications
- AI in cancer detection
- Medical Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
- Circular RNAs in diseases
- Sleep and related disorders
- Occupational Health and Performance
- Cardiac Ischemia and Reperfusion
- Angiogenesis and VEGF in Cancer
- Urban Transport and Accessibility
- Heterotopic Ossification and Related Conditions
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
Nanjing Sport Institute
2011-2024
Anqing City Hospital
2024
Anhui Medical University
2024
Chenzhou First People's Hospital
2024
Weifang Medical University
2023
Nanjing Medical University
2011-2022
Hebei Medical University
2022
Zhejiang University
2022
Jiangsu Province Hospital
2022
Shanghai Ninth People's Hospital
2018-2021
The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division. Aur-A dysregulation represents an oncogenic event that promotes tumor formation. Here, we report breast cancer metastasis. overexpression enhanced mammary migration by dephosphorylation activation of cofilin, which facilitates actin reorganization polymerization. Cofilin knockdown impaired Aur-A-driven protrusion membrane. Conversely, activated cofilin...
Mitotic serine/threonine kinase Aurora-A (Aur-A) plays a critical role in regulating centrosome segregation and spindle assemble. Aur-A overexpression causes excessive duplication abnormal structure, leading to tumor malignant progression. Here, we investigated expression nasopharyngeal carcinoma (NPC) the association between NPC invasiveness. We showed that of tissues was correlated with cranial bone invasion clinical stage patients. Suppression by either selective Aurora inhibitory VX-680...
Abstract Aims Management of blood glucose fluctuation is essential for diabetes. Exercise a key therapeutic strategy diabetes patients, although little known about determinants glycemic response to exercise training. We aimed investigate the effect combined aerobic and resistance training on in type 2 patients explore predictors exercise‐induced response. Materials Methods Fifty sedentary were randomly assigned control or group. Participants group maintained lifestyle weeks, those...
Melanoma is resistant to conventional chemotherapy and radiotherapy. Therefore, it essential develop a targeted, low-toxic, minimally invasive treatment. Here, DTIC/ICG-Fe3O4@TpBD BSP/HA microneedles (MNs) were designed fabricated, which can enhance targeting melanoma perform photothermal therapy (PTT) simultaneously synergistically exert anticancer effects. The system consisted of magnetic nanoparticles (DTIC/ICG-Fe3O4@TpBD), dissoluble matrix (Bletilla polysaccharide (BSP)/hyaluronic acid...
Abstract Background The mitotic Aurora-A kinase exerts crucial functions in maintaining fidelity. As a bona fide oncoprotein, aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by which enhances cancer cell survival remain be elucidated. Results Here, we found that was closely correlated with clinic stage and lymph node metastasis tongue carcinoma. inhibitory VX-680 suppressed proliferation, induced apoptosis markedly reduced migration cells. We further showed...
Objective: The physiological characteristics and acute responses underpinning uphill running differ from those of downhill remain less understood. This study aimed to evaluate time-course changes muscle-specific microRNA (miRNA) in striated muscle or circulation response running. Methods: Male Sprague-Dawley rats (n = 84) were randomly assigned a sedentary group 12) an exercise 72). performed 90 min (quadriceps, gastrocnemius, soleus, cardiac muscle) (plasma, exosome, exosome-free) levels...
Background Accurate prognostication of locally advanced nasopharyngeal carcinoma (NPC) will benefit patients for tailored therapy. Here, we addressed this issue by developing a mathematical algorithm based on support vector machine (SVM) through integrating the expression levels multi-biomarkers. Methodology/Principal Findings Ninety-seven NPC in randomized controlled trial (RCT), consisting 48 cases serving as training set and 49 testing SVM models, with 5-year follow-up were studied. We...
Pressure ulcers (PUs) are a major clinical problem that constitutes tremendous economic burden on healthcare systems. Deep tissue injury (DTI) is unique serious type of pressure ulcer arises in skeletal muscle tissue. DTI part because tissues more susceptible than skin to external compression. Unfortunately, few effective therapies currently available for injury. Basic fibroblast growth factor (bFGF), potent mitogen and survival various cells, plays crucial role the regulation development...
Abstract Background Resistance training with blood flow restriction (BFR) is a physiological ischaemic method. Before it applied to patients coronary artery disease, must be proven safe and effective. Methods Twenty-four healthy adult males were randomly assigned three groups: the resistance (RT) group, low-pressure BFR (LP-RT) group high-pressure (HP-RT) group. The protocol was 20 times/min/set, 2-min break, five sets/day 5 d/week for 8 weeks. Cardiac function, haemodynamics vascular...
Background: The effect of resistance exercise on the autonomic nervous system patients with hypertension has not been identified. Objective: To explore a suitable training method for to regulate blood pressure (BP) and function. Method: Forty-five aged between 55 70 years were randomly equally divided into three groups: high-intensity (HE) group, low-intensity combined flow restriction (LE-BFR) (LE) group. All performed quadriceps femoris exercise. intensity HE, LE-BFR LE group was 65, 30...
Objective: The purpose of this study was to explore the effect blood flow-restricted low resistance training on microvascular rarefaction in myocardium spontaneously hypertensive rats (SHRs). Methods: Four-week-old male SHRs were randomly divided into following groups: Wistar-Kyoto (WKY), SHR control (SHR-SED), high-intensity (HIRT), low-intensity (LIRT), and (BFRT). exercise groups began receive intervention for 8 weeks at age 7 weeks. Blood pressure (BP), heart rate (HR), cardiac function,...
Objective: The aim of this study was to investigate the protective effect physiologic ischemic training normal skeletal muscle against myocardial infarction. Design: Thirty-five rabbits were implanted with water balloon constrictors in left ventricular branch cause ischemia and an electrode near sciatic nerve for electric stimulation training. Three groups randomly selected: pure (PI) group received 2 mins, two times a day, five week; exercise (ET) as did PI group, plus 4 mins training,...
The aim of this study was to test the effects physiologic ischemic training on performance skeletal muscle in a pathologically limb models.Twenty-seven New Zealand white rabbits were randomly assigned three groups: (1) those ischemia with cuff inflation group received right femoral artery ligation and occlusion blood flow left by 3 mins followed 5 deflation, repeated times; (2) isometric exercise 4 contraction 10 rest, twice; (3) sole no intervention limb. Five weeks later, endurance,...
To investigate the association between objective sleep parameters and glycaemic variability determined by continous glucose monitoring (CGM) among patients with type 2 diabetes, given significant role of in control.In this study, CGM was carried out 28 T2D (aged 62.3 ± 4.8 years, 57% women). Sleep characteristics were assessed actigraphy within period. CGM-derived outcomes included level, percentages time range (TIR) above (TAR) during Associations intraindividual night-to-night variations...
The aim of this study was to investigate the effects physiologic ischemia training (PIT) on proliferation endothelial progenitor cells (EPCs) and corresponding changes in influencing factors atherosclerotic rabbits, including vascular growth factor (VEGF) nitric oxide (NO).Eighteen rabbits were assigned randomly three groups: a high-fat diet (HD) group, an HD-with-training (HT) control group. Rabbits HD HT groups fed food those group administered PIT from seventh week onward. Atherosclerotic...