A5069580938- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Mechanical Circulatory Support Devices
- Genomics and Chromatin Dynamics
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Advanced Fluorescence Microscopy Techniques
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Aquatic Ecosystems and Phytoplankton Dynamics
- Immune Cell Function and Interaction
- Hydraulic and Pneumatic Systems
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Advanced Electron Microscopy Techniques and Applications
- Mercury impact and mitigation studies
- Cell Image Analysis Techniques
Tongling University
2025
Southern University of Science and Technology
2021-2025
Jinan University
2015-2025
Soochow University
2023-2025
QIMR Berghofer Medical Research Institute
2015-2024
State Key Joint Laboratory of Environment Simulation and Pollution Control
2024
Research Center for Eco-Environmental Sciences
2024
Xi'an Jiaotong University
2022-2024
Binzhou Medical University
2020-2024
Guangxi Normal University
2024
Piezoelectric devices integrated into physiological systems can be used effectively for biomedical applications such as sensing biological forces, self-powering devices, stimulating tissue regeneration and healing, diagnosing medical problems. The limitation of current well-established implantable piezoelectric is that most them are non-degradable require extra removal surgery. Biodegradable implants avoid the above dilemma by degrading inside body after fulfilling their service life,...
To define the molecular mechanism(s) by which interleukin (IL)-4 reversibly inhibits formation of osteoclasts (OCs) from bone marrow macrophages (BMMs), we examined capacity this T cell-derived cytokine to impact signals known modulate osteoclastogenesis, include those initiated macrophage colony-stimulating factor (M-CSF), receptor for activation NF-κB ligand (RANKL), tumor necrosis (TNF), and IL-1. We find that although pretreatment BMMs with IL-4 does not alter M-CSF signaling, it blocks...
Abstract The marrow stromal cell is the principal source of key osteoclastogenic cytokine receptor activator NF-κB (RANK) ligand (RANKL). To individualize role cells in varying states TNF-α-driven osteoclast formation vivo, we generated chimeric mice which wild-type (WT) marrow, immunodepleted T and cells, transplanted into lethally irradiated deleted both p55 p75 TNFR. As control, similarly treated WT was mice. Each group administered increasing doses TNF-α. Exposure to high-dose ex vivo...
Transferred CD4+CD25+FoxP3+ Treg cells can prevent autoimmune disease, but generally fail to ameliorate established disease. This study was undertaken compare the effects of antigen-specific induced with interleukin-2 (IL-2) and transforming growth factor β (TGFβ) ex vivo (induced [iTreg] cells) equivalent expanded thymus-derived natural (nTreg) on collagen-induced arthritis (CIA).CIA in DBA/1 mice by immunization type II collagen (CII), before or shortly after immunization, were treated...
A-type lamins are emerging as regulators of nuclear organization and function. Changes in their expression associated with cancer mutations linked to degenerative diseases -laminopathies-. Although a correlation exists between alterations genomic instability, the molecular mechanisms remain largely unknown. We previously found that loss leads degradation 53BP1 protein defective long-range non-homologous end-joining (NHEJ) dysfunctional telomeres. Here, we determined how affects repair...
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking expression of estrogen and progesterone receptors (ER/PR) HER2, thus limiting therapy options. We hypothesized that meta-analysis TNBC gene profiles would illuminate mechanisms underlying the nature this disease identify therapeutic targets. Meta-analysis in Oncomine database identified 206 genes were recurrently deregulated compared with non-TNBC tumors metastasized or led to death within 5 years. This 'aggressiveness...
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and fourth-leading cause of cancer-related deaths worldwide. HCC refractory to many standard cancer treatments prognosis often poor, highlighting a pressing need identify biomarkers aggressiveness potential targets for future treatments. Kinesin family member 2C (KIF2C) reported be highly expressed in several human tumors. Nevertheless, molecular mechanisms underlying role KIF2C tumor development progression have not...
Abstract Multi-channel detection in single-molecule localization microscopy greatly increases information content for various biological applications. Here, we present globLoc, a graphics processing unit based global fitting algorithm with flexible PSF modeling and parameter sharing, to extract maximum from multi-channel single molecule data. As signals data are highly correlated, globLoc links parameters such as 3D coordinates or photon counts across channels, improving precision...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic and electrochemical properties of dimeric Ruthenium(II) diimine complexes determination their excited state redox propertiesYael Fuchs, Sonita Lofters, Thomas Dieter, Wei Shi, Robert Morgan, C. Strekas, Harry D. Gafney, A. David BakerCite this: J. Am. Chem. Soc. 1987, 109, 9, 2691–2697Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April...
Based on the reports of activation transcription factor known as STAT3 (for signal transducers and activators transcription) or APRF acute phase response factor) by various cytokines, we investigated possible role in type I interferon (IFN) receptor signaling. We show that undergoes IFNαdependent tyrosine phosphorylation IFNα treatment induces protein-DNA complexes contain STAT3. In addition, associates with IFNAR-1 chain a phosphorylation-dependent manner upon addition. The binding to...
Failure to reactivate stalled or collapsed DNA replication forks is a potential source of genomic instability. Homologous recombination (HR) major mechanism for repairing the damage resulting from arrest. The single-strand (ssDNA)-binding protein, protein A (RPA), plays role in multiple processes metabolism. However, RPA2 hyperphosphorylation, which occurs response damage, had been unclear. Here, we show that hyperphosphorylated associates with ssDNA and recombinase Rad51 arrest by...
The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use prevent or treat infection. Due antigenically diverse nature envelope (Env), no single antibody is highly active against all viral strains. While physical combination two broadly (bNAbs) can improve coverage majority viruses, clinical-grade manufacturing testing independent products are time resource intensive. In this study, we constructed bispecific...
Abstract Background Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate risk by regulating gene expression. However, pinpointing the exact target association, identifying phenotype it mediates, is a major challenge interpretation translation GWAS. Results Here, we show that pooled CRISPR screens highly effective at GWAS genes defining phenotypes they...
The urgent environmental concern of methane abatement, attributed to its high global warming potential, necessitates the development oxidation catalysts (MOC) with enhanced low-temperature activity and durability. Herein, an iridium-doped PdO
Iron sulfide nanomaterials represented by FeS2 and Fe3S4 nanozymes have attracted increasing attention due to their biocompatibility peroxidase-like (POD-like) catalytic activity in disease diagnosis treatments. However, the mechanism responsible for POD-like activities remains unclear. Herein, taking oxidation of 3,3,5,5-tetramethylbenzidine (TMB) H2O2 on FeS2(100) Fe3S4(001) surfaces, was investigated detail using density functional theory (DFT) calculations experimental characterizations....
Abstract High‐efficiency silicon solar cells featuring doped layer‐based carrier‐selective contacts suffer from optical losses due to parasitic absorption. In this work, a high‐performance electron‐selective contact with high transparency is presented, consisting of intrinsic hydrogenated amorphous (a‐Si:H) passivation layer, atomic‐layer‐deposited conductive magnesium oxide (MgO x ) and low‐work‐function aluminium zinc (AZO). The a‐Si:H/MgO /AZO stack demonstrated be an excellent...