A5069763363- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Biochemical and Molecular Research
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Inflammation biomarkers and pathways
- Ferroptosis and cancer prognosis
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Nuclear Receptors and Signaling
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Congenital heart defects research
- Pulmonary Hypertension Research and Treatments
Guangzhou Medical University
2018-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2020-2025
Third Affiliated Hospital of Guangzhou Medical University
2022
Augusta University
2014-2020
Nanjing University of Chinese Medicine
2018
Wuxi People's Hospital
2017
Nanjing Medical University
2008-2017
Georgia Regents Medical Center
2015
University of Toronto
1995-2011
Energy deprivation activates the cellular energy sensor AMP-activated protein kinase (AMPK), which in turn induces macroautophagy/autophagy. The mitochondrial-associated ER membrane (MAM) plays a key role mitochondrial division and autophagy, fusion MFN2 (mitofusin 2) tethers MAM, but mechanism by AMPK regulate autophagy response to stress remains unclear. Here, we found that not only triggers fission more importantly increases number of MAMs, process requires AMPK. Interestingly, under...
Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin resistance. To better understand the pathophysiology of obesity-associated NAFLD, present study examined involvement adipose tissues in metformin actions on reducing hepatic steatosis inflammation during obesity. C57BL/6J mice were fed a high-fat diet (HFD) for 12 weeks to induce NAFLD treated (150 mg/kg/d) orally last four HFD feeding. Compared HFD-fed control mice, metformin-treated showed improvement...
Background Influenza A viruses ( IAV ) result in severe public health problems with worldwide each year. Overresponse of immune system to infection leads complications, and ultimately causing morbidity mortality. Objective Curcumin has been reported have anti‐inflammatory ability. However, its molecular mechanism responses remains unclear. Methods We detected the pro‐inflammatory cytokine secretion nuclear factor kappa‐light‐chain‐enhancer activated B cell NF ‐κB)‐related protein expression...
Switching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to dedifferentiated (proliferative) contributes neointima formation, which has been demonstrated possess tumor-like nature. Dysregulated glucose and lipid metabolism is recognized as hallmark tumors but not thoroughly elucidated in formation. Here, we investigated the cooperative role glycolysis fatty acid synthesis injury-induced VSMC dedifferentiation We found that expression hypoxia-inducible factor-1α (HIF-1α)...
Abstract Background Stent implantation-induced neointima formation is a dominant culprit in coronary artery disease treatment failure after percutaneous intervention. Ferroptosis, an iron-dependent regulated cell death, has been associated with various cardiovascular diseases. However, the effect of ferroptosis on remains unclear. Methods The mouse common right carotid arteries were ligated for 16 or 30 days, and tissues collected further analyses. Primary rat vascular smooth muscle cells...
Abstract Aims The activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in endothelial cells (ECs) contributes to vascular inflammation atherosclerosis. Considering the high glycolytic rate ECs, we delineated whether and how glycolysis determines NLRP3 Methods results Our demonstrated a significant up-regulation 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3), key regulator glycolysis, human mouse atherosclerotic endothelium, which...
Abstract The accumulation of lactate in tissue microenvironments is associated with atherosclerosis, but its precise role atherogenesis remains largely unknown. This study demonstrated that aortic tissues and blood correlated increased monocarboxylate transporter 1 (Mct1) expression endothelial cells (ECs) within atherosclerotic plaques. Lactate uptake via Mct1 triggers an inflammatory response ECs. administration endothelial‐targeting nanoparticles containing siRNA against reduces...
Pediatric sepsis is a complex and life-threatening condition characterized by organ failure due to an uncontrolled immune response infection. Recent studies suggest that ferroptosis, newly identified form of programmed cell death, may play role in progression. However, the specific mechanisms ferroptosis pediatric remain unclear. In this study, we analyzed microarray datasets from healthy blood samples identify ferroptosis-associated genes. A protein-protein interaction (PPI) network...
Mitochondrial dysfunction fuels vascular inflammation and atherosclerosis. calcium uptake 1 (MICU1) maintains mitochondrial Ca2+ homeostasis. However, the role of MICU1 in atherosclerosis remains unknown. Here, we report that endothelial prevents by maintaining We observed was aggravated cell-specific Micu1 knockout mice (Micu1ECKO) attenuated transgenic (Micu1ECTg). Furthermore, hypercholesterolemic Micu1ECKO also showed accelerated development atherosclerosis, while Micu1ECTg were...
The circadian clock is a transcriptional network that functions to regulate the expression of genes important in anticipation changes cellular and organ function. Recent studies have revealed recognition pathogens subsequent initiation inflammatory responses are strongly regulated by macrophage-intrinsic clock. We hypothesized pattern gene might be influenced stimuli loss function immune cells can promote pro-inflammatory behavior. To investigate rhythms cells, peritoneal macrophages were...
Background and Purpose Macrophage‐rich atherosclerotic arteries are highly active in glycolysis. PFKFB3, a key glycolytic enzyme, has emerged as potential therapeutic target atherosclerosis. Small‐molecule inhibitors of such 3PO PFK158, have demonstrated efficacy hampering atherogenesis preclinical models. However, genetic studies elucidating the role Pfkfb3 need to be conducted validate pharmacological findings unveil side effects. Experimental Approach Apoe −/− mice with global...
Abstract Positive regulation of autophagy by Euryale ferox Salisb (ES) leads to antidepressant effects. This study focused on the potential mechanisms induced petroleum ether fraction ES (ES‐PE) in chronically unpredictable mild stress (CUMS) mouse model. Deficits sucrose preference test, open field tail suspension and forced swim test were observed following CUMS, reversed ES‐PE administration. Contrary expression mammalian target rapamycin, was decreased after establishment CUMS We also...
Guanine nucleotides are required for growth and viability of cells due to their structural role in DNA RNA, regulatory roles translation, signal transduction, cell division. The natural antibiotic mycophenolic acid (MPA) targets the rate-limiting step
Adenosine receptors and extracellular adenosine have been demonstrated to modulate vascular smooth muscle cell (VSMC) proliferation neointima formation. kinase (ADK) is a major enzyme regulating intracellular levels but function in VSMC remains unclear. Here, we investigated the role of ADK injury-induced delineated mechanisms underlying its action.
Abstract Different kinds of factors contribute to gastric ulcer development which characterized by damaging mucosal layer. However, vascular homeostasis is not well defined and whether andrographolide has a protective function largely unknown. The goal this study investigate the potential roles underlying mechanism regulates in vivo vitro . Gastric animal model induced on pretreated C57/BL6 mouse ethanol intragastric administration. Hematoxylin Eosin Stain, Masson’s trichrome stain...
Despite improvements in cardiovascular disease (CVD) outcomes by cholesterol-lowering statin therapy, the high rate of CVD is still a great concern worldwide. Dehydrocorydaline (DHC) an alkaloidal compound isolated from traditional Chinese herb Corydalis yanhusuo. Emerging evidence shows that DHC has anti-inflammatory and antithrombotic benefits, but whether exerts any antiatherosclerotic effects remains unclear. Our study revealed intraperitoneal (i.p.) injection apolipoprotein E-deficient...
Endothelial dysfunction plays a crucial role in aortic remodeling. Aerobic glycolysis and endothelial-to-mesenchymal transition (EndoMT) have, respectively, been suggested to contribute endothelial many cardiovascular diseases. Here, we tested the hypothesis that glycolytic reprogramming is critical for EndoMT induction remodeling through an epigenetic mechanism mediated by transcriptional corepressor CtBP1 (C-terminal binding protein 1), sensor of glycolysis-derived NADH.EndoMT program,...
ABSTRACT Inosine 5′-monophosphate dehydrogenase (IMPDH), known as GuaB in bacteria, catalyzes the rate-limiting step de novo guanine biosynthesis and is conserved from humans to bacteria. We developed a series of potent inhibitors that selectively target over its human homolog. Here, we show these are bactericidal, generate phenotypic signatures distinct other antibiotics, elicit different time-kill kinetics regulatory responses two important Gram-negative pathogens: Acinetobacter baumannii...