A5079841340- Intracerebral and Subarachnoid Hemorrhage Research
- Immune cells in cancer
- Congenital heart defects research
- TGF-β signaling in diseases
- Kruppel-like factors research
- Cancer-related gene regulation
Tangshan Gongren Hospital
2017-2023
Third Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Background/Aims: Intracerebral hemorrhage (ICH) occurs in hypertensive patients and results high rates of mortality disability. This study determined whether bone marrow mesenchymal stem cell (BMSC) transplantation affects axonal regeneration examined the underlying mechanisms after administration PD98059 (p-ERK1/2 inhibitor) or/ LY294002 (PI3K inhibitor). The hypothesis that was intended to be tested BMSC regulates expression growth-associated protein-43 (GAP-43) via ERK1/2 PI3K/Akt...
Endothelial dysfunction plays a crucial role in aortic remodeling. Aerobic glycolysis and endothelial-to-mesenchymal transition (EndoMT) have, respectively, been suggested to contribute endothelial many cardiovascular diseases. Here, we tested the hypothesis that glycolytic reprogramming is critical for EndoMT induction remodeling through an epigenetic mechanism mediated by transcriptional corepressor CtBP1 (C-terminal binding protein 1), sensor of glycolysis-derived NADH.EndoMT program,...
Intracerebral hemorrhage (ICH) is an incurable neurological disease. Microglia activation and its related inflammation contribute to ICH-associated brain damage. FERM domain containing kindlin 1 (FERMT1) integrin-binding protein that participates in microglia-associated inflammation, but role ICH unclear. An model was constructed by injecting 50 µl of autologous blood into the bregma rats. FERMT1 siRNA injected right ventricle rat for knockdown FERMT1. A significant striatal hematoma...