A5101410068- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Immune cells in cancer
- Mycotoxins in Agriculture and Food
- TGF-β signaling in diseases
- ATP Synthase and ATPases Research
- Lipid metabolism and disorders
- Biochemical and Structural Characterization
- CRISPR and Genetic Engineering
- Atherosclerosis and Cardiovascular Diseases
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- PARP inhibition in cancer therapy
- Genetic Syndromes and Imprinting
- Phagocytosis and Immune Regulation
- Developmental Biology and Gene Regulation
- Geological and Geophysical Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Reproductive Biology
- Neuroscience and Neural Engineering
- Angiogenesis and VEGF in Cancer
- Cancer Research and Treatments
Guangzhou Medical University
2021-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Southern University of Science and Technology
2024
China Geological Survey
2024
Hebei University
2024
Central South University
2017-2023
State Key Laboratory of Respiratory Disease
2022
Xinxiang Medical University
2018
Smith-Kettlewell Eye Research Institute
2016
Massachusetts Eye and Ear Infirmary
2016
We have investigated the molecular mechanisms involved in 17 beta-estradiol-induced angiogenic pathway. show here that beta-estradiol promoted a 6-fold increase Jagged1 expression and an 8-fold Notch1 by cDNA arrays breast cancer MCF7 cells. Interestingly, was abrogated incubation with estrogen antagonist, ICI182,780. A similar up-regulation of both receptor ligand found endothelial Additionally, imperfect estrogen-responsive elements were 5' untranslated region genes. Treatment also led to...
Switching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to dedifferentiated (proliferative) contributes neointima formation, which has been demonstrated possess tumor-like nature. Dysregulated glucose and lipid metabolism is recognized as hallmark tumors but not thoroughly elucidated in formation. Here, we investigated the cooperative role glycolysis fatty acid synthesis injury-induced VSMC dedifferentiation We found that expression hypoxia-inducible factor-1α (HIF-1α)...
Abstract Reticulon 3 (RTN3), an endoplasmic reticulum protein, is crucial in neurodegenerative and kidney diseases. However, the role of RTN3 liver tissues has not been described. Here, we employed public datasets, patients, several animal models to explore nonalcoholic fatty disease (NAFLD). The underlying mechanisms were studied primary hepatocytes L02 cells vitro. We found increased expression NAFLD high‐fat diet mice, oxidized low‐density lipoprotein‐treated cells. transgenic mice...
Abstract Aims The activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in endothelial cells (ECs) contributes to vascular inflammation atherosclerosis. Considering the high glycolytic rate ECs, we delineated whether and how glycolysis determines NLRP3 Methods results Our demonstrated a significant up-regulation 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3), key regulator glycolysis, human mouse atherosclerotic endothelium, which...
Abstract The accumulation of lactate in tissue microenvironments is associated with atherosclerosis, but its precise role atherogenesis remains largely unknown. This study demonstrated that aortic tissues and blood correlated increased monocarboxylate transporter 1 (Mct1) expression endothelial cells (ECs) within atherosclerotic plaques. Lactate uptake via Mct1 triggers an inflammatory response ECs. administration endothelial‐targeting nanoparticles containing siRNA against reduces...
Background and Purpose Macrophage‐rich atherosclerotic arteries are highly active in glycolysis. PFKFB3, a key glycolytic enzyme, has emerged as potential therapeutic target atherosclerosis. Small‐molecule inhibitors of such 3PO PFK158, have demonstrated efficacy hampering atherogenesis preclinical models. However, genetic studies elucidating the role Pfkfb3 need to be conducted validate pharmacological findings unveil side effects. Experimental Approach Apoe −/− mice with global...
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel instigator for mitochondrial dysfunction, and plays an important role in the pathogenesis of cardiovascular diseases. However, mechanism DNA-PKcs angiotensin II (Ang II)-induced vascular remodeling remains obscure.Rat aortic smooth muscle cells (SMC) VSMC-specific knockout (DNA-PKcsΔVSMC) mice were employed to examine underlying mechanisms. Blood pressure was monitored using tail-cuff telemetry methods. The function...
Endothelial dysfunction plays a crucial role in aortic remodeling. Aerobic glycolysis and endothelial-to-mesenchymal transition (EndoMT) have, respectively, been suggested to contribute endothelial many cardiovascular diseases. Here, we tested the hypothesis that glycolytic reprogramming is critical for EndoMT induction remodeling through an epigenetic mechanism mediated by transcriptional corepressor CtBP1 (C-terminal binding protein 1), sensor of glycolysis-derived NADH.EndoMT program,...
Nitrososphaeria, formerly known as
A gene (aga0917) encoding a putative b b-agarase was identified from the genome of Pseudoalteromonas fuliginea YTW1-15-1.The nucleotide sequence analysis revealed that aga0917 had significant homology to agarase genes GH16 family.aga0917 encodes protein 290 amino acids with an estimated molecular mass 32.5 kDa, including 21-amino acid signal peptide.A fragment only mature form Aga0917 (269 acids) overexpressed in Escherichia coli BL21 (DE3) pLysS as 6 ¥ histine-tagged fusion (rmAga0917).The...
The Kongquehe Sag, located in the western Lop Nur, has abundant pore subsurface brine. In order to study source and origin, we tested analyzed hydrochemical composition stable isotopes of findings reveal that brine exhibits a moderate low degree mineralization, with values ranging from 50.50 g/L 91.14 g/L. isotope compositions unconfined confined waters are different, mean δD being −8.00‰ −51.75‰ δ18O 10.08‰ −6.01‰. These indicative an intense evaporative environment prevalent Sag area....