A5081538841- Autophagy in Disease and Therapy
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Signaling Pathways in Disease
- Tracheal and airway disorders
- Seismology and Earthquake Studies
- Metabolism, Diabetes, and Cancer
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Receptor Mechanisms and Signaling
- ATP Synthase and ATPases Research
- Ion channel regulation and function
- Adenosine and Purinergic Signaling
- Anomaly Detection Techniques and Applications
- Acute Ischemic Stroke Management
- Cancer-related gene regulation
- Dysphagia Assessment and Management
- Head and Neck Surgical Oncology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
Guangdong Medical College
2020-2024
Guangzhou Medical University
2019-2023
Fudan University
2021
China Medical University
2021
State Key Laboratory of Respiratory Disease
2019-2020
Affiliated Hospital of Guangdong Medical College Hospital
2020
Energy deprivation activates the cellular energy sensor AMP-activated protein kinase (AMPK), which in turn induces macroautophagy/autophagy. The mitochondrial-associated ER membrane (MAM) plays a key role mitochondrial division and autophagy, fusion MFN2 (mitofusin 2) tethers MAM, but mechanism by AMPK regulate autophagy response to stress remains unclear. Here, we found that not only triggers fission more importantly increases number of MAMs, process requires AMPK. Interestingly, under...
Membrane contact sites (MCSs) are defined as regions where two organelles closely apposed, and most MCSs associated with each other via protein-protein or protein-lipid interactions. A number of key molecular machinery systems participate in mediating substance exchange signal transduction, both which essential processes terms cellular physiology pathophysiology. The endoplasmic reticulum (ER) is the largest network within cell has extensive communication organelles, including plasma...
Nasopharyngeal carcinoma (NPC) is a unique malignant tumor of the head and neck. Despite higher survival rates by combination radiotherapy chemotherapy, recurrence or metastasis NPC still occurs at about 10%. Therefore, there urgent demand to develop more effective in vivo models for preclinical trials investigate mechanisms development progression explore better treatment approaches. In this study, we transplanted human CNE1 cells into zebrafish embryos establish xenograft model NPC, where...
Although quantization for linear layers has been widely used, its application to accelerate the attention process remains limited. SageAttention utilizes 8-bit matrix multiplication, 16-bit multiplication with accumulator, and precision-enhancing methods, implementing an accurate 2x speedup kernel compared FlashAttention2. To further enhance efficiency of computation while maintaining precision, we propose SageAttention2, which significantly faster 4-bit (Matmul) alongside additional...
Abstract Gastric cancer (GC) presents a significant global health burden, with metastasis being the leading cause of treatment failure and mortality. NAT10, regulatory protein involved in mRNA acetylation, has been implicated various cancers. However, its role GC, especially concerning immune interactions, remains unclear. Utilizing multi‐omics data from gastric samples, we conducted comprehensive analyses to investigate NAT10 expression, correlation clinical parameters relevance....
Abstract Background Exposure to stress plays a detrimental role in the pathogenesis of hypertension via noninflammatory pathways. Microglial neuroinflammation rostral ventrolateral medulla (RVLM) exacerbates stress-induced (SIH) by increasing sympathetic hyperactivity. Mitochondria microglia are regulators innate immune response. Sigma-1R (σ-1R) localizes mitochondria-associated membranes (MAMs) and regulates endoplasmic reticulum (ER) mitochondria communication, part through its chaperone...
Objective To investigate the effect of percutaneous tracheotomy with deep vein puncture package in severe neurological patients. Methods Forty-five patients diseases admitted to neurosurgery department Fuyang Fifth People’s Hospital from December 2016 October 2019 who underwent were selected as study subjects. According different methods using materials, divided into experimental group (23 cases) and control (22 cases). The received package, while conventional package. Surgical...