A5074462320- RNA and protein synthesis mechanisms
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Brucella: diagnosis, epidemiology, treatment
- Congenital heart defects research
- Bacteriophages and microbial interactions
- Plant Molecular Biology Research
- RNA modifications and cancer
- Bacterial Genetics and Biotechnology
- Plant Stress Responses and Tolerance
- Circular RNAs in diseases
- Air Quality and Health Impacts
- Genomic variations and chromosomal abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Syndromes and Imprinting
- Hedgehog Signaling Pathway Studies
- RNA Research and Splicing
- Air Quality Monitoring and Forecasting
- Wnt/β-catenin signaling in development and cancer
- Biological and pharmacological studies of plants
- Microplastics and Plastic Pollution
Southeast University
2020-2025
Zhongda Hospital Southeast University
2023-2025
Southern Medical University
2025
TCM-Intigrated Cancer Center of Southern Medical University
2023-2024
Karachi Medical and Dental College
2024
University of Education
2020-2023
University of Okara
2020-2023
Academy of Scientific and Innovative Research
2022-2023
Indian Institute of Integrative Medicine
2022-2023
Hefei Institutes of Physical Science
2019-2021
Transplanted neural stem cells promote tissue regeneration and functional recovery primarily by releasing paracrine factors. Exosomes act as important secreted molecules to deliver therapeutic agents involved in cellular functions. Here, we focused on the role of exosomes (hNSC-Exo) derived from human (hNSCs). We utilized pro-inflammatory factor interferon gamma (IFN-γ) induce generation altered (IFN-γ-hNSC-Exo), compared their roles with those hNSC-Exo explored potential mechanism....
Using engineered exosomes produced from stem cells is an experimental therapeutic approach for treating brain diseases. According to reports, preclinical research has demonstrated notable neurogenesis and angiogenesis effects using modified cell-derived exosomes. These biological nanoparticles have a variety of anti-apoptotic, anti-inflammatory, antioxidant properties that make them very promising nervous system disorders.
A diverse and large community of gut microbiota reside in the intestinal tract various organisms play important roles metabolism immune homeostasis its host. The disorders microbiota-host interaction have been closely associated with numerous chronic inflammatory metabolic diseases, including bowel disease type 2 diabetes. accumulating evidence has shown that fine particulate matter (PM2.5) exposure contributes to diabetes, atherosclerosis diseases; however, few studies explored impact...
Stroke has significantly contributed to the global mortality rate over years, emphasizing urgency of finding effective treatment strategies. Neural stem cell (NSC)-derived exosomes have potential improve neurological recovery after stroke; however, their therapeutic efficacy is hindered by rapid clearance and limited duration action. This study presents an innovative drug delivery method: a hydrogel based on NSC hydroxypropyl methylcellulose (HPMC), which intended offer continuous release,...
Abstract Plant microRNAs (miRNAs) are noncoding and endogenous key regulators that play significant functions in regulating plant responses to stress, growth development. Heat stress is a critical abiotic reduces the yield quality of flowering Chinese cabbage ( Brassica campestris L. ssp. chinensis var. utilis Tsen et Lee). However, limited information available on whether miRNAs involved regulation heat B. . A high-throughput sequencing approach was used identify novel conserved...
Biallelic variants in PUS3 have recently been recognized as a rare cause of neurodevelopmental disorders. Pseudouridine synthase-3 encoded by is an enzyme important for modification various RNAs, including transfer RNA (tRNA). Here we present the clinical and genetic features 21 individuals with biallelic variants: seven new 14 previously reported individuals, where two were updated. The information collected through collaborations or literature search. All characterized local clinicians...
Intellectual disability (ID) has become very common and is an extremely heterogeneous disorder, where the patients face many challenges with deficits in intellectual functioning adaptive behaviors. A single affected family revealed severe disease phenotypes such as ID, developmental delay, dysmorphic facial features, postaxial polydactyly type B, speech impairment. DNA of a individual was directly subjected to whole exome sequencing (WES), followed by Sanger sequencing. Data analysis novel...
Heat stress disturbs cellular homeostasis, thus usually impairs yield of flowering Chinese cabbage (Brassica campestris L. ssp. chinensis var. utilis Tsen et Lee). MicroRNAs (miRNAs) play a significant role in plant responses to different stresses by modulating gene expression at the post-transcriptional level. However, roles that miRNAs and their target genes may heat tolerance remain poorly characterized. The current study sequenced six small RNA libraries generated from leaf tissues...
Cohen Syndrome (COH1) is a rare autosomal recessive disorder, principally identified by ocular, neural and muscular deficits. We three large consanguineous Pakistani families with intellectual disability in some cases autistic traits.Clinical assessments were performed order to allow comparison of clinical features other VPS13B mutations. Homozygosity mapping followed whole exome sequencing Sanger strategies used identify disease-related mutations.We two novel homozygous deletion mutations...
Bardet-Biedl syndrome (BBS) is a rare clinically and genetically heterogeneous autosomal recessive multi-systemic disorder with 22 known genes. The primary clinical diagnostic features include six different hallmarks, such as rod-cone dystrophy, learning difficulties, renal abnormalities, male hypogonadism, post-axial polydactyly, obesity. Here, we report nine consanguineous families non-consanguineous family several affected individuals presenting typical of BBS. In the present study, 10...