A5021598210- Cancer therapeutics and mechanisms
- Microtubule and mitosis dynamics
- Computational Drug Discovery Methods
- Aquaculture disease management and microbiota
- Animal Nutrition and Physiology
- Monoclonal and Polyclonal Antibodies Research
- Indoor Air Quality and Microbial Exposure
- Long-Term Effects of COVID-19
- Effects of Environmental Stressors on Livestock
- Traditional and Medicinal Uses of Annonaceae
- Cancer-related gene regulation
- Carcinogens and Genotoxicity Assessment
- Nigella sativa pharmacological applications
- Genomic variations and chromosomal abnormalities
- Pomegranate: compositions and health benefits
- Cancer Genomics and Diagnostics
- Bioactive Compounds and Antitumor Agents
- Natural Antidiabetic Agents Studies
- Education and Critical Thinking Development
- Graphene and Nanomaterials Applications
- Creativity in Education and Neuroscience
- Circadian rhythm and melatonin
- Cytokine Signaling Pathways and Interactions
- Phytochemical and Pharmacological Studies
- Liver Disease Diagnosis and Treatment
Imam Abdulrahman Bin Faisal University
2019-2025
University College of Bahrain
2023
University of Bahrain
2023
Banning antibiotic growth promoters has negatively impacted poultry production and sustainability, which led to exploring efficient alternatives such as probiotics, synbiotics. Effect of in ovo injection Bacillus subtilis, raffinose, their synbiotics on performance, cecal microbial population volatile fatty acid concentration, ileal histomorphology, gene expression was investigated broilers (Gallus gallus) raised for 21 days. On 300 h incubation, a total 1,500 embryonated eggs were equally...
Background: Breast cancer remains a significant global health concern, with approximately 2.3 million diagnosed cases and 670,000 deaths annually. Current targeted therapies face challenges such as resistance adverse side effects. This study aimed to explore natural compounds potential multitargeted breast therapeutics, focusing on Lucidin, an anthraquinone derived from Rubia cordifolia, comparing its efficacy Lapatinib, FDA-approved drug. Methods: We performed molecular docking studies key...
Intellectual disability (ID) has become very common and is an extremely heterogeneous disorder, where the patients face many challenges with deficits in intellectual functioning adaptive behaviors. A single affected family revealed severe disease phenotypes such as ID, developmental delay, dysmorphic facial features, postaxial polydactyly type B, speech impairment. DNA of a individual was directly subjected to whole exome sequencing (WES), followed by Sanger sequencing. Data analysis novel...
Chronic hyperglycemia increases the risk of liver damage. Oxidative stress and aberrant inflammatory response are entangled in diabetes-associated injury. This study evaluated protective effect flavonoid galangin (Gal) on glucose intolerance, injury, oxidative stress, response, Nrf2/HO-1 signaling diabetic rats. Diabetes was induced by streptozotocin (STZ), rats received Gal for six weeks. STZ-induced showed hypoinsulinemia, elevated glycated hemoglobin (HbA1c), decreased glycogen....
The Food and Drug Administration (FDA) approved a new class of anti-diabetic medication (a sodium–glucose co-transporter 2 (SGLT2) inhibitor) in 2013. However, SGLT2 inhibitor drugs are under evaluation due to their associative side effects, such as urinary tract genital infection, discomfort, diabetic ketosis, kidney problems. Even clinicians have difficulty recommending it patients the increased probability infection. In our study, we selected natural inhibitors, namely acerogenin B,...
Gastric cancer is the fifth most frequent and third major cause of mortality worldwide. Helicobacter pylori, a bacterial infection linked with GC, injects cytotoxin-associated antigen A (CagA; an oncoprotein) into host cells. When phosphorylated CagA protein enters cell, it attaches to other cellular components, interfering normal signaling pathways. plays important role in progression GC by interacting phosphatidylserine cell membrane. Therefore, disrupting CagA-phosphatidylserine...
Age-related hearing loss (AHL) is the most common sensory disorder of aged population. Currently, one important sources experimental medicine for AHL medicinal plants. This study performed first investigation effect thymoquinone (TQ), a potent antioxidant, on AHL. Here, we used inbred C57BL/6J mice (B6 mice) as successful model early onset The behavioral assessment revealed that injection high dose TQ (40 mg/kg;
This study explored the growth efficiency and intracellular pathways by which Cnicus benedictus extract (CBE) acts. It investigated antioxidant effects efficacy of CBE as a fish supplement in attenuation Aeromonas hydrophila Oreochromis niloticus fish. Mono-sex Nile tilapia ( n = 225) were randomly allocated to five groups triplicate aquaria 3 tanks per group, 15 tank, with 120 L water tank) daily exchange rate 20%. After adaption for 2 weeks body weight measuring, experimental fed...
Background: Polydactyly is a prevalent digit abnormality characterized by having extra digits/toes. Mutations in eleven known genes have been associated to cause nonsyndromic polydactyly: GLI3, GLI1, ZRS regulating LMBR1, IQCE, ZNF141, PITX1, MIPOL1, FAM92A, STKLD1, KIAA0825, and DACH1 . Method: A single affected family member (IV-4) was subjected whole-exome sequencing (WES) identify the causal gene. Bi-directional Sanger performed segregate identified variant within family. In silico...
The purpose of this study was to investigate the effects a design-thinking-based teaching method on optimizing students’ motivation and understanding cell biology. This is based creativity creating solutions primarily human focused. It involves five-step process: discovery, explanation, thinking, experimenting, developing. In study, researchers employed empathy in redesigning content after each class student feedback reflections. sample included 92 female students: 50 design-thinking...
This study was conducted to evaluate the protective role of extracted natural antioxidants from black rice and their effect on kidney failure renal cirrhosis caused by ethanol-induced toxicity. Antioxidant activity in terms total phenol content, flavonoid compounds anthocyanin, as well antioxidant capacity, determined an extract rice. The findings noted that contained high amounts capacity. Total phenolic were fractionated using HPLC results showed ferulic, sinapic, ascorbic, salicylic...
The coronavirus disease outbreak of 2019 (COVID-19) poses a serious threat to public health worldwide. Lung injury is the most common complication Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, other organs, including liver, can also be affected. Currently, there limited evidence that liver impairment associated with severe SARS-CoV-2 Clinicians will need determine whether caused by an underlying condition, COVID-19 therapy, virus directly, or...
Human noroviruses (NV) are the most prevalent cause of sporadic and pandemic acute gastroenteritis. NV infections substantial morbidity death globally, especially amongst aged, immunocompromised individuals, children. There presently no authorized vaccines, small-molecule therapies, or prophylactics for humans. 3 C L protease (3CLP) has been identified as a promising therapeutic target anti-NV drug development. Herein, we employed structure-based virtual screening method to screen library...
Although Annona squamosa Linn. (Annonaceae) has been used in traditional medicine and is known to have several pharmacological properties, its impact on EGFR kinase not fully investigated. An assay (biochemical) was govern the potential of different A. seed extracts scavenge free radicals petroleum ether, acetone, ethanol, methanol. We also tested leaf for their ability inhibit growth HEK 293, MCF7, HepG2 cell lines. The PSE, ASE, ESE, MSE all contained anti-cancer substances like anethole,...
Aromatase plays a significant role in the progression of estrogen receptor-positive (ER-positive) breast cancer. The adverse side effects currently used aromatase inhibitors (AIs) necessitate development new AIs that are more active, selective, and less toxic. This study computational approach to screen 503 natural compounds ZINC database against active site. best scoring hits ZINC69482055, ZINC69482510, ZINC406719 exhibited strong binding with aromatase, energy values -8.45, -10.35, -8.75...
Abstract Cervical cancer remains a significant global health concern that starts in the cervix, lower part of uterus connects to vagina and is caused by human papillomavirus (HPV), necessitating development effective multitargeted resistance-proof therapies. In early-stage cervical may not show any symptoms, however, as progresses, some people experience- abnormal vaginal bleeding, watery or bloody discharge, pain pelvis back, during sex, frequent painful urination. this study, we screened...