A5046830835- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Synthesis and biological activity
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Animal Virus Infections Studies
- Diabetes Treatment and Management
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Diverse Scientific Research Studies
- Immunotherapy and Immune Responses
- Genomics and Phylogenetic Studies
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Tuberculosis Research and Epidemiology
- Plant Virus Research Studies
- Microbial Natural Products and Biosynthesis
- Antibiotic Resistance in Bacteria
- Cancer therapeutics and mechanisms
- Salmonella and Campylobacter epidemiology
- Poxvirus research and outbreaks
- Pneumonia and Respiratory Infections
Najran University
2021-2025
For the last few years, world has been going through a difficult time, and reason behind this is severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), one of significant members Coronaviridae family. The major research groups have shifted their focus towards finding vaccine drugs against SARS-CoV-2 to reduce infection rate save life human beings. Even WHO permitted using certain vaccines for an emergency attempt cut curve down. However, virus great sense mutation, vaccine's...
The coronaviruses belong to the Coronaviridae family, and one such member, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing significant destruction around world in form of a global pandemic. Although vaccines have been developed, their effectiveness level protection still major concern, even after emergency approval from World Health Organisation (WHO). At community level, no natural medicine currently available as cure. In this study, we screened vast library Drug...
The coronaviridae family has caused the most destruction among all viral families in modern sciences. It is one of recently discovered and added members severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which global pandemic significant worldwide. However, scientists worldwide have developed vaccines, are being given to humans. mutated strain virus various uncertainties about whether drug vaccines affect it. Even after World Health Organization's approval for their effectiveness...
Kingella kingae is a Gram-negative bacterium that causes invasive infections in children and older or immunocompromised individuals, making it significant public health concern. In this study, pan-proteomic mediated vaccine target mining was attempted to identify potential targets K. kingae. Currently, there no available against pathobiont. Therefore, we designed validated an silico construct by targeting the lactoferrin/transferrin-binding TonB-dependent receptor. Antigenic regions of TonB...
Novel strain of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) causes mild to severe respiratory illness. The early symptoms may be fever, dry cough, sour throat, and difficulty in breathing which lead death cases. Compared previous outbreaks like SARS-CoV Middle East (MERS), SARS-CoV2 disease (COVID-19) outbreak has been much distressing due its high rate infection but low fatality (IFR) with 1.4% around the world. World Health Organization (WHO) declared a pandemic on March...
Breast cancer begins in the breast cells, mainly impacting women. It starts cells that line milk ducts or lobules responsible for producing and can spread to nearby tissues other body parts. In 2020, around 2.3 million women across globe received a diagnosis, with an estimated 685,000 deaths. Additionally, 7.8 were living cancer, making it fifth leading cause of cancer-related deaths among The mutational changes, overexpression drug efflux pumps, activation alternative signalling pathways,...
Klebsiella aerogenes is a Gram-negative bacterium which has gained considerable importance in recent years. It involved 10% of nosocomial and community-acquired urinary tract infections 12% hospital-acquired pneumonia. This organism an intrinsic ability to produce inducible chromosomal AmpC beta-lactamases, confer high resistance. The drug resistance K. been reported China, Israel, Poland, Italy the United States, with mortality rate (~50%). study aims combine immunological approaches...
Colorectal cancer (CRC) ranks third among all cancers in terms of prevalence. There is growing evidence that gut microbiota has a role the development colorectal cancer. Fusobacterium nucleatum overrepresented gastrointestinal tract and tumor microenvironment patients with CRC. This suggests F. as potential risk factor Hence, we aimed to explore whole genomes strains related CRC predict therapeutic markers through pan-genome integrated subtractive genomics approach. In current study,...
The Food and Drug Administration (FDA) approved a new class of anti-diabetic medication (a sodium–glucose co-transporter 2 (SGLT2) inhibitor) in 2013. However, SGLT2 inhibitor drugs are under evaluation due to their associative side effects, such as urinary tract genital infection, discomfort, diabetic ketosis, kidney problems. Even clinicians have difficulty recommending it patients the increased probability infection. In our study, we selected natural inhibitors, namely acerogenin B,...
Background/Objectives: Laryngeal squamous cell carcinoma (LSCC) is the most prevalent form, accounting for nearly 95% of laryngeal cancer. This study evaluates effectiveness chemotherapy and radiation therapy combined treating LSCC, along with exploring miR-449a as a potential biomarker predicting treatment response prognosis in LSCC patients. Patients Methods: The had 81 patients advanced cancer 50 healthy controls. Chemotherapy was given two cycles, followed by an evaluation response....
One of the most important breakthroughs in healthcare is development vaccines. The life cycle and its gene expression numerous virus-associated disorders must be considered when choosing target vaccine antigen for Epstein-Barr virus (EBV). candidate used current study will also effective against all other herpesvirus strains, based on conservancy study, which verified that protein present herpesviruses. From screening, two B-cell epitopes, four MHC-I, five MHC-II restricted epitopes were...
Background: Cervical cancer originates in the cervix, lower part of uterus, and results from uncontrolled growth abnormal cervical cells, forming malignant tumours. It poses a major global health challenge, calling for innovative drug design strategies to enhance treatment outcomes. Method: In this study, we have screened FDA-approved library against four proteins, MCM10, MCM6, DNA polymerase epsilon subunit-2, TBK1, which are essential replication, repair, cellular signalling pathways,...
Campylobacter ureolyticus is a Gram-negative, anaerobic, non-spore-forming bacteria that causes gastrointestinal infections. Being the most prevalent cause of bacterial enteritis globally, infection by this bacterium linked with significant morbidity and mortality in children immunocompromised patients. No information on pan-therapeutic drug targets for species available yet. In current study, pan-genome analysis was performed 13 strains C. to prioritize potent from identified core genome....
Streptococcus pneumoniae contributes to a range of infections, including meningitis, pneumonia, otitis media, and sepsis. Infections by this bacterium have been associated with the phenomenon molecular mimicry, which, in turn, may contribute induction autoimmunity. In study, we utilized bioinformatics approach investigate potential for S. incite autoimmunity via mimicry. We identified 13 proteins that significant sequence similarity human proteins, 11 them linked autoimmune disorders such as...
SARS-CoV-2 is a recently discovered virus that poses an urgent threat to global health. The disease caused by this termed COVID-19. Death tolls in different countries remain rise, leading continuous social distancing and lockdowns. Patients of ages are susceptible severe disease, particular those who have been admitted ICU. Machine learning (ML) predictive models based on medical data patterns emerging topic areas such as the prediction liver diseases. Prediction combine several variables or...