A5085959080- Computational Drug Discovery Methods
- Synthesis and biological activity
- vaccines and immunoinformatics approaches
- Cancer-related molecular mechanisms research
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Pneumonia and Respiratory Infections
- MicroRNA in disease regulation
- Essential Oils and Antimicrobial Activity
- Moringa oleifera research and applications
- RNA Research and Splicing
- Circular RNAs in diseases
- Phytochemistry and Biological Activities
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Biological and pharmacological studies of plants
- Digital Imaging for Blood Diseases
- Protein Structure and Dynamics
- Marine Sponges and Natural Products
- Phytochemicals and Medicinal Plants
- Nerve injury and regeneration
- Venomous Animal Envenomation and Studies
- Cancer, Lipids, and Metabolism
- Single-cell and spatial transcriptomics
- Medicinal Plant Research
Najran University
2022-2025
University of Glasgow
2024
The Indian Clove (Syzygium aromaticum) is a naturally occurring spice with significant biological properties. It primarily found in India and Indonesia, but can also be cultivated other coastal areas. commonly used as natural preservative the production of medicines. One notable benefits clove its ability to help treat diseases caused by various bacteria fungi, including E. coli, P. aeruginosa, S. aureus, Z. mobilis, C. albicans. Additionally, possesses antioxidant properties that reduce...
Malaria is a mosquito-borne infectious disease that caused by the
Abstract Whilst it is recognised that targeting self-renewal an effective way to functionally impair the quiescent leukaemic stem cells (LSC) persist as residual disease in chronic myeloid leukaemia (CML), developing therapeutic strategies achieve this have proved challenging. We demonstrate regulatory programmes of LSC phase CML are similar embryonic cells, pointing a role for wild type p53 self-renewal. In support this, increasing activity primitive using MDM2 inhibitor combination with...
Breast cancer begins in the breast cells, mainly impacting women. It starts cells that line milk ducts or lobules responsible for producing and can spread to nearby tissues other body parts. In 2020, around 2.3 million women across globe received a diagnosis, with an estimated 685,000 deaths. Additionally, 7.8 were living cancer, making it fifth leading cause of cancer-related deaths among The mutational changes, overexpression drug efflux pumps, activation alternative signalling pathways,...
Inflammation is a protective response to variety of infectious agents. To develop new anti-inflammatory drug, we explored pharmacologically important thiazole scaffold in this study. In multi-step synthetic approach, synthesized seven derivatives ( 5a – 5g ). Initially, examined the vitro potentials our compounds using COX-1, COX-2, and 5-LOX enzyme assays. After confirmation, potential were subjected vivo analgesic studies. The hot plate method was used for analgesia, carrageenan-induced...
Diabetes affects people of all ages, regardless gender and background. To date, there is no evidence for the effect sakuranetin against streptozotocin (STZ)-induced diabetes paradigm. The research was directed to evaluate antidiabetic activity in STZ model invoking diabetes-induced disease (I.P. 60 mg/kg) induce type 2 experimental rats. Recent pursued regulate anti-diabetic ability at both 10 20 mg/kg STZ-induced Furthermore, molecular docking implemented requisite attraction inflammatory...
Background: Malaria remains a global health crisis, with the World Health Organization (WHO) reporting 241 million cases and 627,000 deaths worldwide in 2020, predominantly affecting Sub-Saharan Africa. The region accounted for 95% of 96% deaths, reflecting immense challenges malaria prevention treatment. Plasmodium falciparum Schizont Egress Antigen-1 (PfSEA-1) is crucial facilitating immune evasion promoting sequestration infected red blood cells (RBCs), contributing to severe symptoms,...
Kingella kingae is a Gram-negative bacterium that causes invasive infections in children and older or immunocompromised individuals, making it significant public health concern. In this study, pan-proteomic mediated vaccine target mining was attempted to identify potential targets K. kingae. Currently, there no available against pathobiont. Therefore, we designed validated an silico construct by targeting the lactoferrin/transferrin-binding TonB-dependent receptor. Antigenic regions of TonB...
Background: Nutritional anemia is a significant public health concern worldwide, particularly affecting young adults and children in Saudi Arabia, where inadequate nutrition considered primary contributing factor.This study aims to (i) examine the levels of serum iron, folate, vitamin B 12 adult students, with focus on identifying any deficiencies their association anemia; (ii) explore prevalence mixed-deficiency resulting from (iii) how sociodemographic characteristics dietary habits...
Excessive and imbalance of free radicals within the body lead to inflammation. The objective current research work was explore anti-inflammatory antioxidant potential isolated compounds from Habenaria digitata. In this study, phenolic were investigated for in vitro vivo along with enzyme. assayed via various enzymes like COX-1/2, 5-LOX ABTS, DPPH, H 2 O radical enzyme inhibitory assay. These also explored their activity examining SOD, CAT, GSH-Px, MDA levels brain, heart, liver. evaluated...
Cervical cancer poses a substantial worldwide health challenge, especially in low- and middle-income nations, caused by high-risk types of human papillomavirus. It accounted for significant percentage cancer-related deaths among women, particularly areas with limited healthcare resources, necessitating innovative therapeutic approaches, single-targeted studies have produced results, considerable chance developing resistance. Therefore, the multitargeted can work as beacon hope. This study is...
Background: The COVID-19 pandemic caused by SARS-CoV-2 has led to millions of deaths worldwide, and vaccination efficacy been decreasing with each lineage, necessitating the need for alternative antiviral therapies. Predicting host–virus protein–protein interactions (HV-PPIs) is essential identifying potential host-targeting drug targets against infection. Objective: This study aims identify therapeutic target proteins in humans that could act as virus–host-targeting their interaction...
Novel series of nitric oxide-releasing thiazolidine-2,4-diones (
Streptococcus pneumoniae contributes to a range of infections, including meningitis, pneumonia, otitis media, and sepsis. Infections by this bacterium have been associated with the phenomenon molecular mimicry, which, in turn, may contribute induction autoimmunity. In study, we utilized bioinformatics approach investigate potential for S. incite autoimmunity via mimicry. We identified 13 proteins that significant sequence similarity human proteins, 11 them linked autoimmune disorders such as...
Leukemia is a kind of blood cancer that damages the cells in and bone marrow human body. It produces cancerous disturb human’s immune system significantly affect marrow’s production ability to effectively create different types like red (RBCs) white (WBC), platelets. can be diagnosed manually by taking complete count test patient’s blood, from which medical professionals investigate signs leukemia cells. Furthermore, two other methods, microscopic inspection smears aspiration, are also...
AbstractLung Cancer is the one that causes more fatalities in world compared to other cancers, and its uniqueness it can be found both males females. However, recent data has shown are affected due lifestyle habits like smoking, tobacco consumption inhaling polluted air. The World Health Organization kept lung cancer on priority list as 1.8 million deaths worldwide each year, predictions show cases going increase year by 2050, there 3.8 new 3.2 deaths, global health system not prepared for...