A5042152245- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Synthesis and biological activity
- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- vaccines and immunoinformatics approaches
- Berberine and alkaloids research
- Pneumonia and Respiratory Infections
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- Reproductive Biology and Fertility
- Seaweed-derived Bioactive Compounds
- Chemotherapy-induced organ toxicity mitigation
- Polysaccharides and Plant Cell Walls
- Antimicrobial Peptides and Activities
- Carbohydrate Chemistry and Synthesis
- MicroRNA in disease regulation
- Clostridium difficile and Clostridium perfringens research
- Phytochemical Studies and Bioactivities
- Fungal Plant Pathogen Control
- Multicomponent Synthesis of Heterocycles
- Immune cells in cancer
- Diverse Scientific Research Studies
Shaqra University
2021-2025
For the last few years, world has been going through a difficult time, and reason behind this is severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), one of significant members Coronaviridae family. The major research groups have shifted their focus towards finding vaccine drugs against SARS-CoV-2 to reduce infection rate save life human beings. Even WHO permitted using certain vaccines for an emergency attempt cut curve down. However, virus great sense mutation, vaccine's...
In the presented study,
The coronaviruses belong to the Coronaviridae family, and one such member, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing significant destruction around world in form of a global pandemic. Although vaccines have been developed, their effectiveness level protection still major concern, even after emergency approval from World Health Organisation (WHO). At community level, no natural medicine currently available as cure. In this study, we screened vast library Drug...
The coronaviridae family has caused the most destruction among all viral families in modern sciences. It is one of recently discovered and added members severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which global pandemic significant worldwide. However, scientists worldwide have developed vaccines, are being given to humans. mutated strain virus various uncertainties about whether drug vaccines affect it. Even after World Health Organization's approval for their effectiveness...
Kingella kingae is a Gram-negative bacterium that causes invasive infections in children and older or immunocompromised individuals, making it significant public health concern. In this study, pan-proteomic mediated vaccine target mining was attempted to identify potential targets K. kingae. Currently, there no available against pathobiont. Therefore, we designed validated an silico construct by targeting the lactoferrin/transferrin-binding TonB-dependent receptor. Antigenic regions of TonB...
Asthma is a significant health-care burden that has great impact on the quality of life patients and their families. The limited amount previously reported data complicated pathophysiology asthma make it difficult to treat economic public healthcare systems. Ferula asafoetida an herbaceous, monoecious, perennial plant Umbelliferae family. In Asia, F. used range diseases disorders, including asthma. Several in vitro studies demonstrated therapeutic efficacy against Nevertheless, precise...
In the present study, we explored potential of coumarin-based compounds, known for their potent anticancer properties, by designing and synthesizing a novel category 8-methoxycoumarin-3-carboxamides. Our aim was to investigate antiproliferative activity against liver cancer cells. Toward this, developed versatile synthetic approach produce series 8-methoxycoumarin-3-carboxamide analogues with meticulous structural features. Assessment demonstrated significant inhibitory effects on growth...
Colorectal cancer (CRC) ranks third among all cancers in terms of prevalence. There is growing evidence that gut microbiota has a role the development colorectal cancer. Fusobacterium nucleatum overrepresented gastrointestinal tract and tumor microenvironment patients with CRC. This suggests F. as potential risk factor Hence, we aimed to explore whole genomes strains related CRC predict therapeutic markers through pan-genome integrated subtractive genomics approach. In current study,...
Premature ovarian failure (POF) is described as a loss of oocytes and the absence folliculogenesis considered an adverse effect chemotherapeutic drugs, which leads to infertility. Subsequently, existing inquiry was achieved by exploring potential suspicious influences lemon peel extract (LPE), resveratrol (RES) on cyclophosphamide (CPA) induced-POF. The results showed that CPA-induced POF significantly decreased serum estradiol (E2) progesterone levels, along with considerable rise in...
Cancer is a deadly disease characterized by abnormal cell proliferation. Chemotherapy one technique of cancer treatment. Cyclophosphamide (CYP) the most powerful chemotherapy medication, yet it has serious adverse effects. It an antimitotic medicine that regulates proliferation and primarily targets quickly dividing cells, been related to varying levels infertility in humans. In current study, we assessed biochemical, histological, microscopic evaluations testicular damage following...
Background: The World Health Organization (WHO) has declared the multi-drug resistant (MDR) Klebsiella pneumoniae as one of critical bacterial pathogens. dearth new antibiotics and inadequate therapeutic options necessitate finding alternative options. Bacteriophages are known enemies bacteria well-recognized to fight MDR Methods: A total 150 samples were collected from different clinical specimens through a convenient sampling technique. Isolation, identification, antibiotic susceptibility...
Hepatocellular carcinoma (HCC) is one of the most common malignant liver tumors with high mortality. Chronic hepatitis B and C viruses, aflatoxins, alcohol are among causes hepatocellular carcinoma. The limited reported data multiple spectra pathophysiological mechanisms HCC make it a challenging task serious economic burden in health care management. Solanum surattense (S. surattense) herbal plant used many regions Asia to treat disorders including various types cancer. Previous vitro...
Campylobacter ureolyticus is a Gram-negative, anaerobic, non-spore-forming bacteria that causes gastrointestinal infections. Being the most prevalent cause of bacterial enteritis globally, infection by this bacterium linked with significant morbidity and mortality in children immunocompromised patients. No information on pan-therapeutic drug targets for species available yet. In current study, pan-genome analysis was performed 13 strains C. to prioritize potent from identified core genome....
Streptococcus pneumoniae contributes to a range of infections, including meningitis, pneumonia, otitis media, and sepsis. Infections by this bacterium have been associated with the phenomenon molecular mimicry, which, in turn, may contribute induction autoimmunity. In study, we utilized bioinformatics approach investigate potential for S. incite autoimmunity via mimicry. We identified 13 proteins that significant sequence similarity human proteins, 11 them linked autoimmune disorders such as...
Molecular mimicry, a phenomenon in which microbial or environmental antigens resemble host antigens, has been proposed as potential trigger for autoimmune responses. In this study, we employed bioinformatics approach to investigate the role of molecular mimicry Clostridioides difficile-caused infections and induction disorders due phenomenon. Comparing proteomes pathogen, identified 23 proteins that exhibited significant sequence homology were linked disorders. The included rheumatoid...
Kingella kingae is a Gram-negative bacterium that primarily causes pediatric infections such as septicemia, endocarditis, and osteoarticular infections. Its virulence attributed to the outer membrane proteins having implications in bacterial adhesion, invasion, nutrition, host tissue damage. TonB-dependent receptors (TBDRs) play an important role nutrition were previously implicated vaccine targets other bacteria. Therefore, we targeted conserved β-barrel TBDR domain of these for designing...
Vibrio cholerae causes the diarrheal disease cholera which affects millions of people globally. The outer membrane protein U (OmpU) is that most prevalent in V. and has already been recognized as a critical component pathogenicity involved host cell contact being necessary for survival pathogenic body. Computational approaches were used this study to screen total 37,709 natural compounds from traditional Chinese medicine (TCM) database against active site OmpU. Following sequential screening...
Aromatase plays a significant role in the progression of estrogen receptor-positive (ER-positive) breast cancer. The adverse side effects currently used aromatase inhibitors (AIs) necessitate development new AIs that are more active, selective, and less toxic. This study computational approach to screen 503 natural compounds ZINC database against active site. best scoring hits ZINC69482055, ZINC69482510, ZINC406719 exhibited strong binding with aromatase, energy values -8.45, -10.35, -8.75...
Abstract: Background: Genetic disorders such as diabetes have severe implications on human health. Mutation or aberrant activity of different proteins are associated with diabetes. The hyperactivation the peptidase function dipeptidyl peptidase-4 (DPP4) strongly correlates elevated level blood glucose in diabetic patients. Aim: Preventing DPP4 by small molecule modulators is an excellent approach that proposes to curb aggressiveness Blocking quantitatively raises glucagon-like peptide 1...