A5002614805- Sphingolipid Metabolism and Signaling
- Lipid Membrane Structure and Behavior
- Synthesis and biological activity
- Endoplasmic Reticulum Stress and Disease
- Carbohydrate Chemistry and Synthesis
- Lysosomal Storage Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Erythrocyte Function and Pathophysiology
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Click Chemistry and Applications
- Peroxisome Proliferator-Activated Receptors
- Reproductive tract infections research
- Protein Kinase Regulation and GTPase Signaling
- Phagocytosis and Immune Regulation
- Nanoparticles: synthesis and applications
- Polysaccharides and Plant Cell Walls
- Photoreceptor and optogenetics research
- Graphene and Nanomaterials Applications
- RNA regulation and disease
- Bioactive Compounds and Antitumor Agents
- Cellular transport and secretion
Humboldt-Universität zu Berlin
2014-2024
Suez Canal University
2014-2024
Magnesium oxide nanoparticles (MgO-NPs) were synthesized using the fungal strain Aspergillus terreus S1 to overcome disadvantages of chemical and physical methods. The factors affecting biosynthesis process optimized as follows: concentration Mg(NO3)2·6H2O precursor (3 mM), contact time (36 min), pH (8), incubation temperature (35 °C). characterization biosynthesized MgO-NPs was accomplished UV-vis spectroscopy, Fourier transform infrared (FT-IR) transmission electron microscopy (TEM),...
Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining complex with potent biological activity. The structure MTSC ligand its metal was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), thermal differential (DrTGA). spectral analytical data revealed that obtained thiosemicarbazone-metal have...
In the presented study,
Breast cancer is the most common in women, responsible for over half a million deaths 2020. Almost 75% of FDA-approved drugs are mainly nitrogen- and sulfur-containing heterocyclic compounds, implying importance such compounds drug discovery. Among heterocycles, thiazole-based have demonstrated broad range pharmacological activities. In present study, novel set 1,3-thiazole derivatives was designed synthesized based on coupling acetophenone derivatives, phenacyl bromide substituted as key...
Sphingolipids (SLs) are chemically diverse lipids that have important structural and signaling functions within mammalian cells. SLs commonly defined by the presence of a long-chain base (LCB) is normally formed conjugation l-serine palmitoyl-CoA. This pyridoxal 5-phosphate (PLP)-dependent reaction mediated enzyme serine-palmitoyltransferase (SPT). However, SPT can also metabolize other acyl-CoAs, in range C14 to C18, forming variety LCBs differ structure function. Mammalian consists three...
Cancer is one of the leading causes death worldwide. Although several potential therapeutic agents have been developed to efficiently treat cancer, some side effects can occur simultaneously. Papaverine, a non-narcotic opium alkaloid, anticancer drug that showed selective antitumor activity in various tumor cells. Recent studies demonstrated metal complexes improve biological parent bioactive ligands. Based on those facts, herein we describe synthesis novel papaverine–vanadium(III),...
Testicular torsion (TT) is the most common urological emergency in children and young adults that can lead to infertility many cases. The ischemia-reperfusion (IR) injury due TT has been implicated pathogenesis of testicular damage. main pathological mechanisms contralateral after ipsilateral are not fully understood. In presented study, we investigated molecular microscopic basis following detorsion (T/D) explored possible protective role vitamin D3. biochemical analysis indicated IR T/D...
Alcoholism is one of the most common diseases that can lead to development several chronic including steatosis, and cognitive dysfunction. Statins are lipid-lowering drugs commonly prescribed for patients with fatty liver diseases; however, exact effect statins on function still not fully understood. In present study, we have investigated molecular microscopic basis impairment induced by alcohol and/or Atorvastatin (ATOR) administration male Wistar albino rats explored possible protective...
Acute heart failure (AHF) is one of the most common diseases in old age that can lead to mortality. Systemic hypoperfusion associated with hepatic ischemia-reperfusion injury, which may be irreversible. Ischemic hepatitis due AHF has been linked pathogenesis liver damage. In present study, we extensively investigated role mitochondrial dynamics-related proteins and their epigenetic regulation ischemic injury following explored possible hepatoprotective carvedilol. The biochemical analysis...
Inflammation is the main cause of several autoimmune diseases, including type I diabetes, rheumatoid arthritis, bullous pemphigoid, paraneoplastic and multiple sclerosis. Currently, there an urgent demand for discovery novel anti-inflammatory drugs with potent activity but also safe long-term application. Toward this aim, present study reported design, synthesis, characterization a set 1,3-disubstituted-2-thiohydantoins derivatives. The synthesized compounds was assessed against murine...
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of during SL synthesis. 1-deoxySLs toxic to neurons and pancreatic β-cells. Pathologically elevated cause the inherited neuropathy, hereditary sensory autonomic neuropathy type 1 (HSAN1), also found in T2D. Diabetic polyneuropathy (DSN) HSAN1 clinically very similar, suggesting may be implicated both pathologies. considered dead-end...
The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and devoid C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels associated with rare inherited neuropathy, HSAN1, diabetes type 2 might contribute to β cell failure diabetic sensory neuropathy. In analogy sphingolipids, it was assumed that 1-deoxySLs also bear a (4E) double bond, which is normally introduced sphingolipid...
Abstract Ceramide transfer protein (CERT) mediates non‐vesicular of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step sphingomyelin biosynthesis. Usually, CERT ligands are evaluated in tedious binding assays or non‐homogenous using radiolabeled ceramides. Herein, a facile sensitive assay for CERT, based on Förster resonance energy (FRET), is presented. To this end, we mixed donor acceptor vesicles, each containing different fluorescent species....
Abstract Mental disorders are highly comorbid and occur together with physical diseases, which often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis 456,693 volunteers found associations haplotypes SMPD3 coding for NSM-2 (NSM) alcohol consumption, but also affective state, bone mineralisation. Functional mice showed that NSM controls behaviour, their...
Canagliflozin (CFZ) is a sodium-glucose cotransporter-2 inhibitor (SGLT2) that lowers albuminuria in type-2 diabetic patients, cardiovascular, kidney, and liver disease. CFZ classified as class IV the Biopharmaceutical Classification System (BCS) characterized by low permeability, solubility, bioavailability, most likely attributed to hepatic first-pass metabolism. Nanocrystal-based sublingual formulations were developed presence of sodium caprate, wetting agent, permeability enhancer. This...
Abstract Alkaline ceramidases (ACERs) are a class of poorly understood transmembrane enzymes controlling the homeostasis ceramides. They implicated in human pathophysiology, including progressive leukodystrophy, colon cancer as well acute myeloid leukemia. We report here crystal structure ACER type 3 (ACER3). Together with computational studies, reveals that ACER3 is an intramembrane enzyme seven domain architecture and catalytic Zn 2+ binding site its core, similar to adiponectin receptors....
Thiazole-substituted pyrazole is an important structural feature of many bioactive compounds, including antiviral, antitubercular, analgesic and anticancer agents. Herein we describe efficient facile approach for the synthesis two series 36 novel N-bridged pyrazole-1-phenylthiazoles. The antiproliferative activity a set representative compounds was evaluated in vitro against different human cancer cell lines. Among identified compound 18 showed potent examined silico molecular docking study...
Abstract Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes in human physiology. The central metabolite ceramide, a pro‐apoptotic lipid catabolized ceramidase produce pro‐proliferative sphingosine‐1‐phosphate. Alkaline ceramidases are transmembrane that recently attracted attention for drug development fatty liver diseases. However, due their hydrophobic nature, no specific small molecule inhibitors have been reported. We present the discovery and...