A5072546882- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Nutrition and Health in Aging
- Autism Spectrum Disorder Research
- Liver Disease and Transplantation
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Genomics, phytochemicals, and oxidative stress
- Family and Disability Support Research
- Parasites and Host Interactions
- Bladder and Urothelial Cancer Treatments
- PI3K/AKT/mTOR signaling in cancer
- Electromagnetic Fields and Biological Effects
- Acute Myeloid Leukemia Research
- Cancer-related cognitive impairment studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Biochemical Acid Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Eicosanoids and Hypertension Pharmacology
Ain Shams University
2018-2024
Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis ASD-associated cellular and behavioral deficits. This study aimed at investigating chronic memantine (20 mg/kg/day) aripiprazole (3 combination therapy management prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits male Wistar rats. Pregnant female rats received single...
Acute heart failure (AHF) is one of the most common diseases in old age that can lead to mortality. Systemic hypoperfusion associated with hepatic ischemia-reperfusion injury, which may be irreversible. Ischemic hepatitis due AHF has been linked pathogenesis liver damage. In present study, we extensively investigated role mitochondrial dynamics-related proteins and their epigenetic regulation ischemic injury following explored possible hepatoprotective carvedilol. The biochemical analysis...
Abstract Urinary bladder cancer is a common malignancy in Egypt, thus reliable methodologies are required for screening and early detection. In this study, we analyzed the gene expression of Schistosoma hematobium specific microRNA “ Sha-miR-71a ” mitogen-associated protein kinase-3 (MAPK-3) urine samples 50 patients with benign bilharzial cystitis. Fifty control subjects were also tested. Indirect hemagglutination test (IHA) diagnosed 70% studied cases as associated (BBC), while...
Abstract The utilization of digital technology has grown rapidly in the past three decades. With this rapid increase, cell phones emit electromagnetic radiation; that is why field (EMF) become a substantial new pollution source modern civilization, mainly having adverse effects on brain. While such topic attracted many researchers’ scopes, there are still minimal discoveries made regarding chronic exposure to EMF. extensive use may affect children's cognition even indirectly if parents and...
Acute liver failure induces renal injury by triggering inflammation and oxidative stress. The heme oxygenase system has a preventive role against reperfusion injury, while garlic oil antioxidants anti-inflammatory effects. This study investigated the protective effects of pretreatment on remote functions after ischemia/reperfusion (I/R), clarifying gene expressions 1 (HO1), autophagy-related 7 (Atg7) peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) in tissues....
Abstract Autistic children frequently struggle with cognitive flexibility. The potential molecular mechanism underlying inflexibility remains unclear. Decreased level of brain-derived neurotrophic factor (BDNF), which plays a vital role in neural development and synaptic plasticity may have role. This study aimed to investigate the effects memantine on (BDNF) expression hippocampus prenatal VPA exposed rats, its consequent Pregnant female rats received single intraperitoneal injection (600...
Background:The possibility of exposure to a considerable amount electromagnetic waves exists all around us.The hippocampus is involved in spatial memory and learning processes which could be compromised by cell phone emitted radiofrequency (RF)-electromagnetic field (EMF .(Objective: To explore the effect EMF on hippocampal function throw more attention mechanisms interaction form acetylcholine (ACh), glutamate, malondialdehyde (MDA) cellular responses mediated autophagy (Atg7 gene...
Background: Type 2 diabetes mellitus (DM) has many complications associated with increased morbidity and mortality. Cardiovascular are one of these serious complications. Therefore, there is a need for early effective management to hamper them. This study aimed evaluate the cardioprotective efficacy metformin myoinositol combination through exploring underlying mechanisms in type DM rat model. Methods: model was induced rats by streptozotocin high-fat diet. Rats were treated (150 mg/kg)...
Abstract Diabetes mellitus (DM) is a worldwide health problem. Many factors participate in the pathogenesis of DM, including genetic, autoimmune, metabolic, dietary and environmental factors. Intact mitochondrial function essential for prompt cellular metabolism energy balance. Malfunctioning mitochondria lead to disturbed glucose therefore evolving DM. Epigenetics plays role control geneencoded proteins dynamics. One primary epigenetic effectors family long non-coding RNAs. The lncRNA, H19...
Background: Type 2 diabetes mellitus (DM) has many complications associated with increased morbidity and mortality. Cardiovascular are one of these serious complications. Therefore, there is a need for early effective management to hamper them. This study aimed evaluate the cardioprotective efficacy metformin myoinositol combination through exploring underlying mechanisms in type DM rat model. Methods: model was induced rats by streptozotocin high-fat diet. Rats were treated (150 mg/kg)...