A5072403574- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- COVID-19 and Mental Health
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Mental Health Treatment and Access
- Chronic Lymphocytic Leukemia Research
- melanin and skin pigmentation
- Resilience and Mental Health
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Cardiac Ischemia and Reperfusion
- Hair Growth and Disorders
- Radiation Dose and Imaging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transgenic Plants and Applications
- Galectins and Cancer Biology
- Cardiac Fibrosis and Remodeling
- HER2/EGFR in Cancer Research
- Neonatal and Maternal Infections
Ain Shams University
2016-2025
Egypt Center for Research and Regenerative Medicine
2022-2024
University of Connecticut
2024
Armed Forces College of Medicine
2018-2023
Abstract Background The current pandemic of COVID-19 impacted the psychological wellbeing populations globally. Objectives We aimed to examine extent and identify factors associated with distress, fear coping. Methods conducted a cross-sectional study across 17 countries during Jun-2020 Jan-2021. Levels distress (Kessler Psychological Distress Scale), (Fear coping (Brief Resilient Coping Scale) were assessed. Results A total 8,559 people participated; mean age (±SD) was 33(±13) years, 64%...
Mortality rates of acute lymphoblastic leukemia (ALL) have improved over the past 20 years; however, a significant portion deaths stems from lack prognostic biomarkers, which can direct therapy and overcome drug resistance. microRNA-155a (miRNA-155a) miRNA-181a are two single-stranded miRNAs involved in pathogenesis many types lymphoma is linked to We investigated their expression levels 55 patients, 45 diagnosed with ALL 10 as control group. found that miRNA-155a were significantly...
Aims To investigate the biological impact of simultaneous overexpression lncRNA MEG3 and miR-155, termed a "double hit," on multiple myeloma (MM) cells compared to individual biomarker substitution.
Abstract Refractory Diffuse Large B-cell Lymphoma (DLBCL) presents a major therapeutic challenge due to its resistance standard treatments. Engineered T-cells, especially Chimeric Antigen Receptor (CAR) have shown promise in overcoming drug resistance. This study investigates the effectiveness of WEE1-engineered T-cells targeting and eliminating refractory DLBCL vitro. CAR were created by transducing 5th-generation construct designed recognize WEE1, surface antigen commonly found on cells....
ABSTRACT Background Long noncoding RNAs (lncRNAs) have emerged as key regulators of cancer; in addition, they been identified novel therapeutic targets and biomarkers for several cancers, including diffuse large B‐cell lymphoma (DLBCL). Methods A total 75 DLBCL patients 30 control subjects with active lymph nodes were enrolled into our study. The baseline expression levels lncRNAs HOTAIR, MALAT1, PANDA paraffin‐embedded blocks from controls evaluated using reverse transcription quantitative...
Abstract Background Accurate estimation of the time since deposition biological samples is a critical aspect forensic investigations, as it can provide important temporal information about crime scenes. Saliva stains, frequently encountered in casework, degrade over time, and their analysis offer clues timing events. Recent advances molecular techniques have focused on using RNA degradation rates time-dependent biomarker due to instability molecules post-deposition. This study explores...
Aberrant microRNA (miRNA) expression participates in childhood acute lymphoblastic leukemia (ALL). This study aimed to investigate the of miRNA-100, miRNA-196a, and miRNA-146a among ALL their correlation with other hematological parameters different phenotypes. Peripheral blood mononuclear cells (PMNCs) were obtained from 85 25 healthy children for detection miRNA using quantitative real-time PCR. Significant higher median levels reported compared control children. The diagnostic efficacy...
Aberrant expression of miRNAs has a link with tumorgenesis and their deregulation is reported in biological fluids cancer patients. Authors aimed to investigate the diagnostic role miRNA-17-5p, miR-155 miRNA-222 serum samples from breast patients (n = 80), benign 40) healthy individuals 30) using quantitative real-time PCR technique. Median levels investigated markers revealed significant increase primary followed by control groups. Investigated relation clinical stages histological grading,...
Abstract Aim and Background Malignant pleural mesothelioma (MPM) is a lethal cancer mainly caused by chronic exposure of asbestos. In this pilot study, we aimed to assess the expression serum RNA‐based biomarker panel exploring their clinical utility as diagnostic prognostic biomarkers for MPM. Methods We have selected an MPM‐specific through bioinformatics analysis based on integration DNA damage regulated autophagy modulator 1 ( DRAM1 ) arylsulfatase A ARSA gene with epigenetic regulators...
Abstract Emerging hepatocellular carcinoma (HCC) has been sequentially reported in chronic hepatitis C virus (HCV) treated with direct‐acting antivirals (DAAs). Homeobox transcript antisense RNA ( HOTAIR ), an oncogene, to be associated cancer. We investigated the predictive value of lnc‐HOTAIR for HCC surveillance HCV patients following DAAs therapy. The expression levels and ATG‐7 genes were measured 220 HCV, a based therapy 12 weeks, followed‐up attentive months after starting DAAs. In...
Aim: miRNAs may act as promising diagnostic and prognostic biomarkers of mesothelioma. This study integrates serum miR-548a-3p miR-20a expression based on in silico data analysis followed by clinical validation malignant mesothelioma patients (malignant pleural [MPM]). Patients & methods: Serum level was assessed the with MPM, chronic asbestos exposure healthy volunteers quantitative real-time PCR. Results: The positive 91.6 96.7% MPM patients, respectively. Both were able to segregate...
Background: Currently, no blood biomarkers exist that can diagnose unstable angina (UA) patients. Nourin is an early inflammatory mediator rapidly released within 5 min by reversible ischemic myocardium, and if ischemia persists, it also necrosis. elevated in acute coronary syndrome (ACS) patients but not symptomatic noncardiac healthy subjects. Recently, circulating microRNAs (miRNAs) have been established as markers of disease, including cardiac injury inflammation. Objectives: To profile...
Abstract Purpose The major struggle in peri-implantitis therapy is the availability of successful decontamination infected implant surface. main hypothesis this study was Er,Cr: YSGG laser efficacy investigation on surfaces with various defects. primary objective to decide Er,Cr:YSGG as a tool at simulating secondary compare oral biofilm removal between two protocols first protocol (4 cycles 2.5 min) and second (5 5 Materials methods A total 3 subjects whose plaque biofilms formed in-vivo...
Abstract Hepatitis C virus (HCV) infection is a major public health problem, having high prevalence in Egypt. Leukemia and lymphoma have been associated with HCV infection. MicroRNA‐155 (miR‐155) has reported to play regulatory role cancer, inflammation, immune response The expression level of miR‐155 viremic patients controversial; although levels were demonstrated genotypes 1,2, 3, low detected Egyptian genotype 4. Several studies investigated the correlation between miRNA‐155 replication...
Surgical methods are favorably used for treatment of stable vitiligo, and platelet-rich plasma (PRP) can be added to augment the effect. The additive value PRP, however, remains elusive. Basic fibroblast growth factor (bFGF) is released from activated platelets with a capacity stimulating melanocyte proliferation migration. outcomes mini-punch grafting (MPG)/phototherapy without PRP were assessed relation between bFGF obtained results evaluated. Thirty-four vitiliginous patches, two per each...
Background: Although cardiovascular imaging techniques are widely used to diagnose myocardial ischemia in patients with suspected stable coronary artery disease (CAD), they have limitations related lack of specificity, sensitivity and “late” diagnosis. Additionally, the absence a simple laboratory test that can detect CAD patients, has led many being first diagnosed at time development infarction. Nourin is an early blood-based biomarker rapidly released within five minutes by “reversible”...
Healthcare workers (HCWs) have been impacted psychologically due to their professional responsibilities over the prolonged era of coronavirus disease 2019 (COVID-19) pandemic. The study aimed identify predictors psychological distress, fear, and coping during COVID-19 pandemic among HCWs.A cross-sectional online survey was conducted self-identified HCWs across 14 countries (12 from Asia two Africa). Kessler Psychological Distress Scale, Fear Brief Resilient Coping Scale were used assess...