Despite the significant advances in management of coronary heart diseases, myocardial infarction (MI) is still associated with a high mortality rate. The present study was planned to investigate possible protective effects anti-oxidants lipoic acid and zinc sulfate as well anti-platelet clopidogrel on cardiac dysfunction experimental isoproterenol (ISO)-induced MI, aiming at achieving useful means for protection therapy against MI. Wistar rats both sexes were allocated into five groups:...

Abstract The utilization of digital technology has grown rapidly in the past three decades. With this rapid increase, cell phones emit electromagnetic radiation; that is why field (EMF) become a substantial new pollution source modern civilization, mainly having adverse effects on brain. While such topic attracted many researchers’ scopes, there are still minimal discoveries made regarding chronic exposure to EMF. extensive use may affect children's cognition even indirectly if parents and...

Systemic and organ-specific oxidative stress triggered by hypoxia is suggested to play a key role in germ cell apoptosis DNA damage. This study was designed investigate the impact of chronic intermittent (CIH) on female fertility evaluate potential antioxidant effect L-arginine (L-Arg) supplementation.Adult rats were allocated into three groups: controls (normoxic), hypoxic supplemented with L-Arg. After 12 weeks; hematocrit value determined, body weight (BW) ovarian measured for calculation...

What is the central question of this study? impact and drawbacks subcutaneous lipectomy on body metabolism? main finding its importance? Subcutaneous resulted in deterioration hepatic functions, atherosclerotic lipid profile disturbed redox state. While results support as an effective treatment for obesity, induces unfavourable changes health.The number obese older adults rise, but data about proper obesity elderly controversial. The present study was designed to investigate effectiveness...

Conditions associated with chronic hypoxia increase morbidity and mortality attributable to cardiovascular complications. Myocardial is a common feature in several diseases including: stroke, infarction, anaemia, lung diseases, obstructive sleep apnoea cyanotic congenital heart defects. The present study was planned investigate the effects of intermittent its association increased myocardial oxidative stress. In addition, evaluate protective effect chromium supplementation, aiming at...

Background:The possibility of exposure to a considerable amount electromagnetic waves exists all around us.The hippocampus is involved in spatial memory and learning processes which could be compromised by cell phone emitted radiofrequency (RF)-electromagnetic field (EMF .(Objective: To explore the effect EMF on hippocampal function throw more attention mechanisms interaction form acetylcholine (ACh), glutamate, malondialdehyde (MDA) cellular responses mediated autophagy (Atg7 gene...

Abstract Purpose The deleterious effect of visceral adipose tissue accumulation is well known. However, the recent trend in liposuction mal-directed toward easily accessible subcutaneous fat for purpose body shaping. aim present study to probe metabolic effects abdominal lipectomy ovariectomized obese rats as role adipokines these changes. Methods was conducted on young female randomized into two main groups according duration experiment, namely, 5-week and 10-week. Both were subdivided...

Re-perfusion is the standard therapy for acute myocardial infarction, despite associated pathologies that may contribute to irreversible injury. The present study aims clarify alterations in cardiac activities response experimental ischemic arrest followed by re-perfusion isolated hearts perfused with nitric oxide (NO) donor, l-arginine, or NO inhibitor, Nω-Nitro-l-arginine methyl ester hydrochloride (l-NAME), shed light on possible role of process.Hearts from adult Wistar rats were studied...

Objective Aging has been reported to be associated with disturbed gastric emptying. Thus, we aimed study the changes in emptying and motility aging. Materials methods The present was carried out on 42 male Sprague–Dawley rats divided into four groups: 10 adult control rats, aged 11 N-ω-nitro-L-arginine methyl ester (L-NAME)-treated L-arginine-treated rats. Body weight food intake were monitored for 2 weeks. At end of study, examined in-vitro recording motility. Results Weight gain...

End-stage renal disease (ESRD) is a leading cause of morbidity and mortality, affecting an estimated 13% the population worldwide.Currently there no complete cure for ESRD, and, although condition can be managed with hemodialysis, it does not restore homeostatic endocrine functions kidney.Therefore, only functional restorative treatment these patients kidney transplantation.However, shortage available donor organs, associated immunosuppression, as well high rate organ rejection, supports...

Background: Re-perfusion strategies are the current standard therapy for acute myocardial infarction, despite spectrum of re-perfusionassociated pathologies that may contribute to irreversible injury. Aim work:The aim present study is clarify alterations in intrinsic cardiac functions response ischemic arrest followed by re-perfusion isolated hearts perfused with nitric oxide (NO) donor, Larginine, or NO inhibitor, Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME), shed light on...

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including central obesity, hypertension, insulin resistance, dyslipidemia, and hyperglyemia. MetS found to be positive predictor morbidity mortality. The present study was planned test the efficacy vitamin D3 supplementation as compared with cortisol inhibition on parameters. Wistar rats were allocated into four groups: control, untreated MetS, treated either (10 µg/kg) or carbenoxolone (50 mg/kg). induced by combination...