The medical education system is currently facing robust challenges as a consequence of the coronavirus disease (COVID-19) pandemic. One them maintenance interactive learning techniques such team-based (TBL). Team-based an teaching method that learner centred and instructor directed. It sequentially involves self-work followed by teamwork. After providing reading material, students are commonly asked to solve 10-20 multiple choice questions, known individual readiness assurance test (iRAT)....

Here, we examined the protective effect of ferulic acid (FA) on cadmium chloride (CdCl2)-mediated reproductive toxicity in male rats. Animals were divided into four groups: control, FA (20 mg/kg), CdCl2 (6.5 and + CdCl2. treatment evoked a significant increase testis concentration addition to obvious testosterone, luteinizing hormone, follicle-stimulating hormone levels. Moreover, CdCl2-induced oxidative damage through exhausting cellular defenses (superoxide dismutase, catalase, glutathione...

Computational chemistry, molecular docking, and drug design approaches, combined with the biochemical evaluation of antitumor activity selected derivatives thiouracil-based dihydroindeno pyrido pyrimidines against topoisomerase I II. The IC50 other cell lines including normal human lung line W138, cancer line, A549, breast MCF-7, cervical cancer, HeLa, liver HepG2 was evaluated using methods. global reactivity descriptors physicochemical parameters were computed, showing good agreement...

Cyclodextrin nanosponges are solid nanoparticles, designed by cross-linking of cyclodextrin polymer; it has been used widely as a good delivery system for water insoluble drugs. The aim this study is to enhance the solubility Piroxicam (PXM) using β-Cyclodextrin based formulations. PXM nanosponge (PXM-NS) formulations were prepared β-cyclodextrin and carbonyldiimidazole cross linker, three ratios crosslinker in addition drug tested. characterized its particle size, zeta potential, physical...

Herein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53, ATR, ATM, CHEK1 and CHEK2 involved OSCC using NG-WES their analysis bioinformatics tools. Out of 42 identified mutations, 16.7% are for the 1st time. A total 28 nonsynonymous SNVs identified. TP53 harbored highest number followed by CHEK2. Nine (TP53p.R43H, TP53p.L125Q, TP53p.R116Q, TP53p.C110Y, TP53p.L62F, ATRp.H120Y, ATMp.P1054R, ATMp.D1853V, ATMp.T2934N) were predicted highly pathogenic. SAAFEQ-SEQ destabilizing...

Arthritic disorder is a common disease in elderly patients and the most cause of joint dysfunction. This study aims to design Piroxicam-loaded nanoemulsion (PXM-NE) formulations enhance analgesic anti-inflammatory activity drug for topical use.The preparations were designed based on high-pressure homogenization technique characterized particle size (PS), poly dispersity index (Pi), zeta potential (ZP), content, selected formula was investigated its pharmacokinetic parameters.The...

Abstract: To prolong the residence time of dosage forms within gastrointestinal tract until all drug is released at desired rate one real challenges for oral controlled-release delivery systems. This study was designed to develop a floating matrix tablet and raft system Mebeverine HCl (MbH) evaluate different excipients their behavior in vitro profiles. Oral pharmacokinetics optimum tablet, formula, marketed Duspatalin ® 200 mg retard as reference were studied beagle dogs. The optimized...

Dark septate endophytes (DSEs) are often trace element (TE)-tolerant fungi and abundant in TE-polluted environments. The production of melanin, a black polymer found cell walls, was hypothesized by several authors to play role the TE tolerance DSEs. To test this hypothesis, we established series experiments using albino strains melanin inhibitors examined responses Cd Zn. Six DSEs belonging genera Cadophora sp., Leptodontidium sp. Phialophora mustea, were evaluated. mainly produced...

The aim of this work was to formulate glimepiride (class II drug) which is characterized by low solubility and high permeability as nanostructured particles using a cryogenic technique with an aid water-soluble polymer improve its aqueous hence bioavailability. 27 formula nano size were prepared spray freezing into liquid (SCFL) poly vinyl pyrrolidone K-30 (PVP K-30); that three drug ratio (1:1, 1:2, 1:3), different volumes feeding solution (50, 100, 150 mL), at flow rates (10, 20, 30...

Development of new approaches for oral delivery an existing antiviral drug aimed to enhance its permeability and hence bioavailability. Ganciclovir (GC) is that belongs class III in biopharmaceutical classification. The encapsulation poorly absorbed drugs within nanosized particles offers several characteristics due their acquired surface properties. In the following study, solvent evaporation technique was used incorporate GC, elegant nanosize using cyclodextrin shellac polymers enhancing...

Hepatocellular carcinoma (HCC) is a highly prevalent malignancy. It common type of cancer in Egypt due to chronic virus C infection (HCV). Currently, the frequently used lab test serum α-fetoprotein. However, its diagnostic value challenging low sensitivity and specificity. Genetic biomarkers have recently provided new insights for diagnostics. Herein, we quantified Lnc HULC miR-122 gene expression their potential diagnosis. Both were tested sera 60 HCC patients with HCV using real-time...

Abstract Urinary bladder cancer is a common malignancy in Egypt, thus reliable methodologies are required for screening and early detection. In this study, we analyzed the gene expression of Schistosoma hematobium specific microRNA “ Sha-miR-71a ” mitogen-associated protein kinase-3 (MAPK-3) urine samples 50 patients with benign bilharzial cystitis. Fifty control subjects were also tested. Indirect hemagglutination test (IHA) diagnosed 70% studied cases as associated (BBC), while...

Vitiligo is an autoimmune dermatological disorder, precipitated by genetic and nongenetic factors leading to destruction of epidermal melanocytes. In Egypt, it has a prevalence rate 1.2%. Vitamin D stimulatory protective effects on melanocytes acts through its nuclear vitamin receptor (VDR) target cells. The consequences polymorphisms in VDR have been previously studied for mapping their link with various disorders etiology.To study Apa-I Taq-I single-nucleotide (SNPs) the risk develop...

Controlling the drug release from dosage form at a definite rate is main challenge for successful oral controlled-release delivery system. In this study, mini-tablets (MTs) and lipid/polymer nanoparticles (LPNs) of lipid polymer chitosan in different ratios were designed to encapsulate control time Amoxicillin (AMX).Physical characteristics vitro profiles both MT LPN formulations studied. Antimicrobial activity pharmacokinetics optimum comparison market tablet studied rats.All AMX as MTs...

<b>Background and Objective:</b> Oxaliplatin<sup>®</sup> is an antineoplastic platinum-based compound; nephrotoxicity one of its most serious side effects. This study aimed to explore the nephroprotective potential Costus Ethanolic Extract (CEE) against Oxaliplatin<sup>®</sup>-induced nephrotoxicity. <b>Materials Methods:</b> Adult male Wistar rats, weighting 140-160 g, were randomly divided into four groups: (1) Normal (2) Rats ingested with...

Traditional teaching methods of biochemistry provide effective tools for knowledge transmission, but are considered less engaging with students. Smartphone applications may suitable alternatives to compensate the shortcomings traditional methods.This study aimed assess effectiveness smartphone as a complementary method learning biochemistry.A total 32 students, from College Applied Medical Sciences, University Bisha, Saudi Arabia, were recruited. Students used available mobile applications,...

The aim of the study was to optimize processing factors precipitation-ultrasonication technique prepare nano-sized particles Lovastatin (LA) for enhancing its solubility, dissolution rate and in vivo bioavailability.LA nanoparticles (LANs) were prepared using under different factors. LANs characterized terms particle size, zeta potential vitro release. Stability studies at 4°C, 25°C 40°C conducted optimum formulation. In addition, bioavailability formula studied comparison a marketed product...

There is an urgent need for more diverse methods student evaluation, given the sudden shift to online learning necessitated by Coronavirus Disease 2019 (COVID-19) pandemic. Innovative assessment tools will cover required competencies and should be used drive self-learning. Self peer assessments may added traditional classroom-based evaluations in order identify individual insecurities or overconfidence. Identification of these factors essential medical education a focus current research. A...

Objective: Development and evaluation of bucco-adhesive films Gliclazide for pediatric use. Methods: Sixteen were formulated using a different combination Gelatin, Hydroxy propyl methyl cellulose (HPMC), polyvinyl alcohol, (HPC), chitosan, polyethylene glycol, sodium alginate, carbopol. Compatibility study drug polymers was conducted differential scanning calorimetry method Fourier transform infrared spectroscopy. All examined content, weight variation, thickness, swelling index,...

The aim of the work was to formulate salbutamol sulfate (SB) microspheres by using superhydrophobic surface (SHS) under different processing factors for improving its encapsulation efficiency, controling release rate, and hence enhancing bioavailability.Cross-linked chitosan (CN) carrageenan (KN) were made on a SHS glutaraldehyde-saturated atmosphere. formulations designed optimized based 42 factorial design. Percentage efficiency (%EE), particle size, swelling ratio, in vitro rate...

Abstract The expression of ACE2 is linked to disease severity in COVID-19 patients. receptor gene polymorphisms are considered determinants for SARS-CoV-2 infection and its outcome. In our study, serum genetic variant S19P rs73635825 polymorphism were investigated 114 results compared with 120 control subjects. ELISA technique allele discrimination assay used measuring genotype analysis rs73635825. Our revealed that was significantly lower patients ( p = 0.0001), particularly cases...

BACKGROUND: Chronic exposure to environmental endocrine disruptors like nonylphenol (NP), has been shown in previous studies predispose non-alcoholic fatty liver disease. METHODS: In this work, forty adult male albino rats were divided into four groups, a high sucrose-high-fat diet (HSHFD) group, group receiving 20 μg/kg/day of NP, an NP + HSHFD and control group. The sacrificed on day 60 after anesthetization. RESULTS: Biochemical tests indicated that serum transaminases (alanine...

Objective: The therapeutic equivalence of generic brands is a great challenge for manufacturers. This study aimed to evaluate the bioequivalence four different atenolol tablets under biowaiver conditions.
 Methods: Physiochemical properties tablet products namely uniformity weight, hardness, disintegration, and drug content were assessed. dissolution profiles conducted in pH 1.2, 4.5, 6.8 7.6 buffers using USP apparatus II. Similarity difference factors calculated. Finally, kinetic...

Objective: Demonstrating therapeutic equivalency regarding the efficacy and safety among originator products generics is a key step in permitting marketing of generic products. The study aimed to evaluate bioequivalence five different brands Glimepiride tablets under biowaiver conditions.
 Methods: quality tablet products, including uniformity weight, friability, disintegration test, was assessed using United State Pharmacopeia (USP) general monograph for dosage form. content...