The study aims to improve the ocular delivery of Nebivolol HCL (NBV) belonging Biopharmaceutics classification system (BCSII) by using spanlastic nanovesicles (SNVs) for ophthalmic and incorporating them into hydroxypropyl methylcellulose gel with ketorolac tromethamine (KET) as an anti-inflammatory glaucoma complications like Conjunctivitis. SNVs were prepared ethanol injection technique span (60) a surfactant labrasol edge activator (EA). impact formulation factors on properties was...

Repaglinide (RPG), a monotherapy insulin secretagogue used to treat diabetes mellitus-type II yet, it suffers from poor water solubility and variable bioavailability (∼ 50%) due hepatic first pass metabolism. In this study, 2FI I-Optimal statistical design was employed encapsulate RPG into niosomal formulations using cholesterol,span 60 peceolTM. The optimized formulation (ONF) showed particle size 306.60 ± 84.00 nm, zeta potential −38.60 1.20 mV, polydispersity index 0.48 0.05 entrapment...

Depression, the second biggest cause of disability worldwide, is widespread. Many antidepressant medications, including Desvenlafaxine Succinate (D.V.S.), function by elevating neurotransmitter levels at synapse through inhibition reabsorption neurons. However, effectiveness these treatments often limited their inability to reach brain using conventional administration methods. Bilosome-stabilized nanovesicles containing bile salts have drawn much interest because adaptability and...

Pomegranate extract (PE) is a natural product with potent antioxidant and anticancer activity because of its polyphenols content. The main purpose this study was to maximize the PE chemotherapeutic efficacy by loading it in an optimized solid lipid nanoparticles (SLNs) formula.The influence independent variables, which were concentration (X1), surfactant (X2) cosurfactant (X3), on dependent ones, particle size (Y1), polydispersity index (Y2), zeta potential (Y3), entrapment efficiency (Y4)...

Objectives: This study was aimed to develop dual-purpose natamycin (NAT)-loaded niosomes in ketorolac tromethamine (KT) gels topical ocular drug delivery system improve the clinical efficacy of through enhancing its penetration corneal tissue and reducing inflammation associated with Fungal keratitis (FK).Significance: Nanosized carrier systems, as would provide great potential for improving NAT bioavailability.NAT niosomal dispersion formulae were prepared then incorporated 0.5%KT using...

Acetazolamide (ACZ) is a diuretic used in glaucoma treatment; it has many side effects. Carvedilol (CAR) non-cardioselective beta-blocker the treatment of elevated intraocular pressure; subjected to first-pass metabolism and causes fluids accumulation leading edema. This study focuses on overcoming previous effects by using topical formula combination two drugs. Sixty formulations niosomes containing Span 20, 60, Tween 60 with different ratios were prepared characterized. Formulation lowest...

It was found that propranolol hydrochloride (PNL), which is a beta-blocker used for hypertension treatment, has potent spermicidal activity through local anesthetic or beta-blocking effect on sperm cells subsequently it could be as contraceptive remedy. This study aimed to entrap PNL into invasomes (INVs) and then formulate locally acting gel. PNL-loaded mucoadhesive INVs were prepared via the thin-film hydration technique. The D-optimal design utilized fabricate employing lipid...

Ondansetron HCl is a (5-HT3) serotonin receptor antagonist, used as anti-emetic drug in combination with anticancer agents. Conventional dosage forms have poor bioavailability and patient compliance. These problems can be reduced by the use of nasal niosomal thermo-reversible situ gelling system. Niosomes were formulated using various surfactants (Span 60, Span 80, Tween 20, 80) different ratios thin-film hydration technique. evaluated for particle size, zeta potential, transmission electron...

This study was designed to optimize the effect of operating conditions and formulation parameters using various additives develop α-amylase nanoparticles. α-Amylase chosen due its importance in substantial number industrial processing with emphasis on pharmaceutical industry. Factorial statistical design adopted effectively size, yield value, residual enzyme activity, morphology nanoparticles Nano Spray Dryer BÜCHI B-90. The physicochemical characterization prepared nanopowder carried out...

The aim of this work was to study the influence process variables on quality attributes pomegranate extract loaded solid lipid nanoparticles (PE-SLNs) using Plackett-Burman design. PE-SLN formulations were prepared by hot homogenization followed ultra-sonication technique and evaluated based dependent that analyzed utilizing Statgraphics Centurion XV software. surfactant (type concentration), co-surfactant concentration, sonication time, amplitude selected as independent (X1-X7). parameters...

Pioglitazone Hydrochloride (PGZ) suffers from poor aqueous solubility. The aim of this research was to design orally disintegrating tablets with self-nanoemulsifying properties (T-SNEDDS) improve the solubility and dissolution rate. Three liquid systems (L-SNEDDS) were formulated evaluated for transmittance percentage, emulsification time, particle size, Poly dispersity index (PDI), percentage content, stability. optimum L-SNEDDS formula converted a solidified drug delivery system (S-SNEDDS)...

A PEGylated Tween 80-functionalized chitosan-lipidic (PEG-T-Chito-Lip) nano-vesicular hybrid was developed for intranasal administration as an alternative delivery route to help improve the poor oral bioavailability of BCS class-III model/antiemetic (metoclopramide hydrochloride; MTC). The influence varying levels chitosan, cholesterol, PEG 600, and 80 on stability/release parameters formulated nanovesicles optimized using Draper-Lin Design. Two formulations (Opti-Max Opti-Min) with both...

This study aimed to formulate and evaluate a floating raft system for the co-delivery of etoricoxib (ETO) famotidine (FAM) using combination glucomannan with natural/semi-synthetic polysaccharides. Formulation variables affect gelation lag time (GLT), (FLT), release percentage drugs after 1-8 h, Stability, viscosity parameters were evaluated. In vivo X-ray studies, followed by pharmacokinetic study, performed on human volunteers. Formulations exhibited pseudoplastic behavior ease swallowing....

Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1),...

Cilostazol (CTZ), is a BCS class II drug with limited bioavailability. In the current study, orally disintegrating tablets (ODTs) for buccal delivery of CTZ were prepared by two methods; lyophilization (Lyo-ODTs) and direct compression (DC-ODTs). All CTZ-ODTs evaluated in vitro disintegration time (DT) wetting (WT) tests, dissolution. Scanning electron microscopic (SEM) analysis was performed selected Lyo-ODT-7 DC-ODT-2. composed aerosil® 200 PEG 4000 acquired shortest DT (13.00 ± 0.14) WT...

Objective: This study aims to develop an intranasal (IN) delivery system for glioblastoma multiforme (GBM) management using repurposed superparamagnetic iron-oxide (SPION) loaded with atorvastatin (ATO)-nanostructured lipid carrier (NLC). Methods: Emulsification and ultrasonication were used formulate ATO-NLCs, the best formula was SPION make final atorvastatin/superparamagnetic iron oxide-loaded nanostructured (ASN) formulation. Entrapment efficiency (EE%), particle size (PS), zeta...

This study aims to develop efficient topical therapy for keratomycosis using sertaconazolenitrate (STZN)-loaded leciplex (LP). The D-optimal design was used optimize STZN-loaded LP by utilizing soy phosphatidylcholine (SPC) molar ratio (X1), cationic surfactant (X2), and type (X3) as the independent variables, whereas their impact studied entrapment efficiency percent (EE; Y1), particle size (PS; Y2), polydispersity index (PDI; Y3), zeta potential (ZP; Y4), permeability coefficient (Kp; Y5)....

The goal of this study was to develop a bilosomal gel formulation enhance transdermal permeability dronedarone hyrdrochloride (DRN) which suffers from poor oral absorption and limited bioavailability. To overcome obstacle, bilosomes were successfully prepared using 23 full-factorial design. Span®40, cholesterol, sodium deoxycholate (bile salt), clove oil (permeability enhancer), either Tween® 60 or 80 (edge activator) used in bilosome preparation by ethanol injection method. In design,...