Repaglinide (RPG), a monotherapy insulin secretagogue used to treat diabetes mellitus-type II yet, it suffers from poor water solubility and variable bioavailability (∼ 50%) due hepatic first pass metabolism. In this study, 2FI I-Optimal statistical design was employed encapsulate RPG into niosomal formulations using cholesterol,span 60 peceolTM. The optimized formulation (ONF) showed particle size 306.60 ± 84.00 nm, zeta potential −38.60 1.20 mV, polydispersity index 0.48 0.05 entrapment...

This research purposed to formulate an optimized imatinib mesylate (IM)-loaded niosomes improve its chemotherapeutic efficacy. The influence of 3 formulation factors on niosomal vesicular size (Y1), zeta potential (Y2), entrapment capacity percentage (Y3), the initial drug release after 2 h (Y4), and cumulative 24 (Y5) were studied using Box-Behnken design. Optimum desirability was specified formula prepared, stability tested, morphologically examined, checked for bilayer formation evaluated...

hydroxyapatite (HAP, Ca10(PO4)6(OH)2) nanoparticles are important biocompatible materials and were successfully synthesized by a new simple precipitation process using calcium hydroxide, phosphoric acid as phosphorus (P) (Ca) precursors sodium hydroxide (NaOH). The crystal structures morphologies of the analyzed X-ray diffractions (X-ray), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), energy dispersive x-ray (EDS) transmission (TEM)....

The purpose of this study was to load diacerein (DCR) in niosomes by applying response surface methodology and incorporate these gel base for topical delivery. Box–Behnken design used investigate the effect charge-inducing agent (X1), surfactant HLB (X2) sonication time (X3) on vesicle size (Y1), entrapment efficiency (Y2) cumulative drug released (Y3). DCR niosomal formulations were prepared thin film hydration method. optimized formula incorporated different bases. gels evaluated...

Avanafil (AVA) is a very efficient phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction. However, it has limited bioavailability when taken orally and considerable first-pass metabolism. Enhancing its solubility choosing an alternative delivery route may enhance effectiveness duration action. Eight complex formulations were elaborated analyzed at various ratios using different polyethylene glycols hydroxypropyl-beta-cyclodextrin (HP-β-CD). Sublingual tablets...

This work aimed to develop a three-dimensional printed (3DP) tablet containing glimepiride (GLMP) and/or rosuvastatin (RSV) for treatment of dyslipidemia in patients with diabetes. Curcumin oil was extracted from the dried rhizomes Curcuma longa and utilized self-nanoemulsifying drug delivery system (SNEDDS). Screening mixture experimental design conducted SNEDDS formulation minimum droplet size. Five different semi-solid pastes were prepared rheologically characterized. The used 3DP tablets...

Tolmetin sodium (TS) is a nonsteroidal anti-inflammatory drug (NSAID) indicated for treatment of musculoskeletal issues. As other NSAID, TS displays marked side effects on the gastro-intestinal (GI) tract after oral administration. Traditional solid suppositories can cause pain and discomfort patients, may reach end colon; consequently, undergo first-pass effect. liquid suppository (TS-LS) was developed to enhance patient compliance rectal mucosal safety in high-risk patients receiving...

An optimized date seed oil (DSO) loaded niosomes was formulated.Maximize the extract anti-inflammatory efficacy and govern its release characteristics from nanoparticles for osteoarthritis prevention treatment purposes.By using Box-Behnken Design, effect of three formulation factors on entrapment efficiency percentage (Y1), initial DSO after 2 h (Y2), cumulative 12 (Y3), were studied. The specified, elaborated, particle size zeta potential assessed, examined morphologically under electron...

This research developed and validated a highly sensitive selective UPLC-MS/MS approach using triple quadrupole mass spectrometer for quantifying favipiravir. Moreover, we introduced study evaluating bioequivalence two drugs, Favibrivix Avigan, containing Lean Six Sigma verified the capacity performance of process. Protein precipitation extraction was utilized to extract favipiravir from collected human matrices. We used an Acquity UPLCr BEH HILIC column valproic acid as internal standard....

This work was aimed to develop a Curcuma oil-based self-nanoemulsifying drug delivery system (SNEDDS) 3D-printed polypills containing glimepiride (GMD) and rosuvastatin (RSV) for treatment of dyslipidemia in patients with diabetes as model metabolic syndrome (MS).

Rosuvastatin (RSV) is a widely used cholesterol-lowering medication, but its limited bioavailability due to susceptibility stomach pH and extensive first-pass metabolism poses significant challenge. A fast-dissolving film (FDF) formulation of RSV was developed, characterized, compared the conventional marketed tablet address this issue. The process involved optimizing thickness, disintegration time, folding durability. All formulations were assessed for in vitro disintegration, endurance,...

Objective: Implementation of a new pharmaceutical technique to improve aqueous solubility and thus dissolution, enhancement drug permeation, finally formulation controlled release tablet loaded with glimepiride (GLMP).Significance: Improve GLMP bioavailability pharmacokinetics in type II diabetic patients.Methods: Different polymers were used enhance which saturated polymeric solution was prepared physically adsorbed onto silica. An experimental design employed optimize the parameters...

Objective: The development of nanosuspension for targeted delivery glibenclamide as hypoglycemic agent to the lung in an inhaler dosage form.Method: Glibenclamide formulations were prepared using Box–Behnken design investigate effect independent factors on dependent variables, Fourier-transform Infrared spectroscopy, Differential Scanning Calorimetry, evaluation and vivo efficacy performed determine effect.Results: results revealed that mean particle sizes ranged from 0.216 0.856 µm, zeta...

Avanafil (AVA) is a second-generation phosphodiesterase-5 (PDE5) inhibitor. AVA shows high selectivity to penile tissues and fast absorption, but has bioavailability of about 36%. The aim was formulate optimize AVA-biodegradable nanoparticles (NPs) enhance bioavailability. To assess the impact variables, Box-Behnken design utilized investigate formulation process variables: AVA:poly (lactic-co-glycolic acid) (PLGA) ratio (w/w, X1); sonication time (min, X2); polyvinyl alcohol (PVA)...

Metformin hydrochloride (MtHCL) is an oral antidiabetic drug and has many other therapeutic benefits. It poor bioavailability, narrow absorption window extensive liver metabolism. Moreover, children elders face difficulty to swallow the commercial tablets.Preparation, in vitro/in vivo evaluation of MtHCL suppositories for rectal administration solve some these problems.Suppository fatty bases (Witepsol®, Suppocire® Massa®; different grades) PEG 1000, 4000 6000 (different ratios), were used...

Self-Emulsifying Drug Delivery System (SEDDS), if taken orally, is expected to self-emulsify in GIT and improve the absorption bioavailability. Probucol (PB) a highly lipophilic compound with very low variable bioavailability.The objectives of this study were examine stability conduct bioavailability prepared Self-Emulsified (PBSEDDS) human volunteers.The methods included preparation different PBSEDDS using soybean oil (solvent), Labrafil M1944CS (surfactant) Capmul MCM-C8 (co-surfactant)....

The aim of this research was the development and optimization nanoniosomes for delivery glibenclamide (Gbn) as hypoglycaemic agent to lung in an inhaler dosage form. Fifteen formulae niosomal dispersions were prepared according Box-Behnken design. effect drug amount, Cholesterol molar ratio, Hydrophilic lipophilic balance (HLB) values surfactant on mean vesicle size, Zeta potential (ZP), polydispersity index (PDI), entrapment efficiency, in-vitro released Gbn investigated. A quality control...