A5063060227- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Ocular Surface and Contact Lens
- Lipid Membrane Structure and Behavior
- Dermatology and Skin Diseases
- Nanoparticle-Based Drug Delivery
- Bee Products Chemical Analysis
- Acne and Rosacea Treatments and Effects
- Hydrogels: synthesis, properties, applications
- Proteins in Food Systems
- Bone health and osteoporosis research
- Polysaccharides Composition and Applications
- Microencapsulation and Drying Processes
- Analytical Methods in Pharmaceuticals
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- Oral microbiology and periodontitis research
- Bone health and treatments
- Coconut Research and Applications
- Phytochemistry and biological activity of medicinal plants
- Retinoids in leukemia and cellular processes
- Sexual function and dysfunction studies
- Nail Diseases and Treatments
King Abdulaziz University
2016-2025
Beni-Suef University
2014-2023
Taif University
2013
Background and objective: Miconazole is a broad-spectrum antifungal drug that has poor aqueous solubility (<1 µg/mL); as result, reduction in its therapeutic efficacy been reported. The aim of this study was to formulate evaluate miconazole-loaded solid lipid nanoparticles (MN-SLNs) for oral administration find an innovative way alleviate the disadvantages associated with commercially available capsules. Methods: MN-SLNs were prepared by hot homogenization/ultrasonication. miconazole...
Solid lipid nanoparticles (SLNs) are prospective carriers for oral delivery of poorly soluble drugs with low bioavailability. Therefore, the study aimed at developing carvedilol (CVD) in SLNs to control its release and enhance bioavailability management hypertension, cardiac diseases. Box-Behnken design (BBD) was applied optimize variables affecting quality CVD-SLNs which prepared by homogenization-ultrasonication technique. The concentrations Percirol (X1), Gelucire (X2), stearylamine (X3)...
Azacitidine (AZA), an inhibitor of DNA methyltransferase, is a commonly recognized drug used in clinical treatment for myelodysplastic syndrome and breast cancer. Due to higher aqueous solubility negative log P AZA causes poor cancer cell permeation controlled release. The objective the present study was formulate optimize AZA-loaded liposome (AZA-LIPO) chemotherapy by using Box Behnken design (BBD) vitro evaluation MCF-7 cells. AZA-LIPO were prepared thin film hydration technique...
The aim of this study was to fabricate and characterize a pharmaceutical emulgel co-loaded with naproxen/eugenol for transdermal delivery improve the analgesic anti-inflammatory effects eliminate GIT adverse reactions. Emulgel prepared using slow emulsification method evaluated physical appearance, thermodynamic stability, viscosity, pH, spreadability, extrudability, in-vitro drug release, content, ex-vivo permeation, retention studies in-vivo studies. exhibited good attributes, being...
Wounds are the most common causes of mortality all over world. Topical drug delivery systems more efficient in treating wounds as compared to oral because they bypass disadvantages route. The aim present study was formulate and evaluate vitro vivo nanoemulgels loaded with eucalyptol for wound healing. Nanoemulsions were prepared using solvent emulsification diffusion method by mixing an aqueous phase oil phase, a nanoemulgel then fabricated nanoemulsions gelling agent (Carbopol 940) 1:1...
The present work aimed to develop nanoparticles of tobramycin (TRM) using thiolated chitosan (TCS) in order improve the mucoadhesion, antibacterial effect and pharmacokinetics. were evaluated for their compatibility, thermal stability, particle size, zeta potential, drug release, kinetics TRM corneal permeation, toxicity ocular irritation. thiolation was confirmed by 1H NMR FTIR, which showed peaks at 6.6 ppm 1230 cm-1, respectively. had a diameter 73 nm, negative potential (-21 mV)...
According to the World Health Organization, 46% of world's children suffer from anemia, which is usually treated with iron supplements such as ferrous sulfate. The aim this study was prepare solid lipid nanoparticles, in order find an innovative way for alleviating disadvantages associated commercially available tablets. These limitations include adverse effects on digestive system resulting constipation and blood stool. second drawback high variability absorption thus its bioavailability....
Abstract: The current study focuses on utilization of the natural biocompatible polymer zein to formulate simvastatin (SMV) nanoparticles coated with caseinate, improve solubility and hence bioavailability, in addition, modify SMV-release characteristics. This formulation can be utilized for oral or possible depot parenteral applications. Fifteen formulations were prepared by liquid–liquid phase separation method, according Box–Behnken design, optimize variables. Sodium caseinate was used as...
Burn wound healing is a complex process that involves the repair of injured tissues and control infection to diminish scar formation, pain, discomfort associated with such injuries. The aim this research was formulate optimize self-nanoemulsion drug delivery system based on use coconut oil loaded simvastatin. Coconut possesses antiinflammatory antibacterial activity, simvastatin has interesting properties for promoting wound-healing because it increases production vascular endothelial growth...
Herpes labialis, caused by herpes simplex virus type 1, is usually characterized painful skin or mucosal lesions. Penciclovir (PV) tablets are found to be effective against labialis but suffer from poor oral bioavailability. This study aimed combine the benefits of PV and lavender oil (LO), which exhibits anesthetic activity, in form a self-nanoemulsifying drug delivery system (SNEDDS) for treatment labialis. Toward this purpose, LO (oil), Labrasol:Labrafil M1944 CS ratio 6:4 (surfactant...
The goal of the current study is to develop a chitosan alginate nanoparticle system encapsulating model drug, simvastatin (SIM-CA-NP) using novel polyelectrolytic complexation method. formulation was optimized central composite design by considering concentrations and at five different levels (coded as +1.414, +1, 0, -1, -1.414) in achieving minimum particle size (PS-Y1) maximum entrapment efficiency (EE-Y2). A total 13 runs were formulated (as projected Design-Expert software) evaluated...
Drug administration to the wound site is a potential method for healing. The drug retention duration should be extended, and permeability through buccal mucosal layer regulated. Oral wounds can caused by inflammation, ulcers, trauma, or pathological lesions; if these are not treated properly, they lead pain, infection, subsequent undesirable scarring. This study aimed develop Kolliphor-407 P-based gel containing neomycin sulfate (NES) loaded in solid lipid nanoparticles (SLNs) enhance...
Candida albicans is the fungus responsible for oral candidiasis, a prevalent disease. The development of antifungal-based delivery systems has always been major challenge researchers. This study was designed to develop nanostructured lipid carrier (NLC) sesame oil (SO) loaded with miconazole (MZ) that could overcome solubility problems MZ and enhance its antifungal activity against candidiasis. In formulation this study, SO used as component liquid showed an improved effect MZ. An optimized...
Fungal eye infections are largely disseminated, especially in developing countries where they may leave over half a million people blind per year. The current study aims to boost the voriconazole antifungal efficiency via loading it as cubosomes (VZ-Cub) into hyaluronic acid and poloxamer-based ocular situ gel. VZ-Cub were fabricated applying Box-Behnken design employing phytantriol, poloxamer F127, VZ amounts independent variables. produced nano vesicles evaluated for dependent variables of...
Abstract In this study, we present a facile and sustainable approach to developing sodium alginate/phytic acid bioaerogels, aiming enhance their thermal insulation flame‐retardant properties. The results reveal that 1% phytic concentration is optimal, resulting in significant reduction conductivity 0.040 W/mK, while also improving specific heat capacity diffusivity. Mechanical tests indicate at concentration, the aerogels achieve superior structural integrity, evidenced by enhanced hardness,...