A5081642528- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Cancer, Lipids, and Metabolism
- Healthcare and Venom Research
- Bee Products Chemical Analysis
- Lipid Membrane Structure and Behavior
- Wound Healing and Treatments
- Sexual function and dysfunction studies
- Curcumin's Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Lipoproteins and Cardiovascular Health
- Analytical Methods in Pharmaceuticals
- Pomegranate: compositions and health benefits
- Pharmacological Effects of Natural Compounds
- Biochemical Acid Research Studies
- Helicobacter pylori-related gastroenterology studies
- Diabetic Foot Ulcer Assessment and Management
- Phytochemical compounds biological activities
- Phytochemicals and Antioxidant Activities
- Urinary Bladder and Prostate Research
- Natural product bioactivities and synthesis
- Dermatology and Skin Diseases
King Abdulaziz University
2016-2025
Cairo University
2013-2025
Minia University
2013-2024
Al-Azhar University
2014-2024
Ain Shams University
2023
Shifa International Hospital
2023
University of Jeddah
2020
American Pharmacists Association
2018
University of Bath
2005-2011
Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for potential in drug delivery of agents. Thus, the purpose this study was determine enhancement ICA cytotoxicity activity OVCAR-3 via its formulation phytosomes. ICA-phytosomal optimized using Box–Behnken design. Particle size, shape, vitro release were used characterize...
Avanafil (AVA) is used in the treatment of erectile dysfunction, but reported for its poor aqueous solubility. Solid lipid nanoparticles (SLNs) are carriers that can greatly enhance drug solubility and bioavailability.This work was aimed to formulate optimize AVA SLNs with subsequent loading into hydrogel films transdermal delivery.AVA were prepared utilizing homogenization followed by ultra-sonication technique. The characterized particle size, charge, surface morphology content. optimized...
Thymoquinone (TQ), a natural polyphenol, has been associated with various pharmacological responses; however, low bioavailability of TQ limits its clinical application. Thus, novel phytosomal delivery system TQ-Phospholipon® 90H complex (TQ-phytosome) was developed by refluxing combined anti-solvent precipitation. This optimized three-factor, three-level Box-Behnken design. The TQ-phytosome size (45.59 ± 1.82 nm) and the vesicle confirmed transmission electron microscopy. in vitro release...
Abstract Bacterial biofilms contribute to increased pathogenesis and bacterial resistance. Biofilms can enhance pathogenicity by shielding bacteria from the immune system antibiotics, they are associated with persistent infections. Additionally, antibiotic resistance mechanisms within make them challenging treat, emphasizing need for strategies be addressed. Mitigating virulence is a promising strategy that could ease their eradication host immunity without stressing induce The merits of...
Optimized nano-transfersomal films for enhanced sildenafil citrate transdermal delivery: ex vivo and in evaluation Shaimaa M Badr-Eldin,1,2 Osamaa AA Ahmed1,3 1Department of Pharmaceutics Industrial Pharmacy, Faculty King Abdulaziz University, Jeddah, Kingdom Saudi Arabia; 2Department Cairo Cairo, Egypt; 3Department Minia Minia, Egypt Abstract: Sildenafil (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used the oral treatment erectile...
Objectives: To optimize and use of glimepiride (GMD)-loaded self-nanoemulsifying delivery systems (SNEDs) for the preparation transdermal patches.
Dapoxetine (DPX) is the drug of choice for specific treatment premature ejaculation. DPX characterized by relatively low bioavailability (42%) and short half-life (1.5 h). The aim this study was to improve delivery across blood-brain barrier (BBB) using a nanostructured formulation improved efficacy patient satisfaction.DPX-loaded polymeric micelles (PMs) formulations (F1-F3) were particle sizes, entrapment efficiencies, Fourier transform infrared spectroscopic transmission electron...
Abstract: The current study focuses on utilization of the natural biocompatible polymer zein to formulate simvastatin (SMV) nanoparticles coated with caseinate, improve solubility and hence bioavailability, in addition, modify SMV-release characteristics. This formulation can be utilized for oral or possible depot parenteral applications. Fifteen formulations were prepared by liquid–liquid phase separation method, according Box–Behnken design, optimize variables. Sodium caseinate was used as...
Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB centrally acting drug has low bioavailability 33% owing to its exposure hepatic first-pass effect, as well pH-dependent solubility, which could be an obstacle hindering dissolution and absorption via mucosal barriers. Thus, this work aimed at overcoming aforementioned drawbacks promoting nose-to-brain delivery...
Piceatannol (PIC), a naturally occurring polyphenolic stilbene, has pleiotropic pharmacological activities. It reported cytotoxic activities against different cancer cells. In the present study, PIC emulsomes (PIC-E) were formulated and assessed for activity. A Box-Behnken design was employed to investigate influence of formulation factors on particle size drug entrapment. After optimization, had spherical shape with 125.45 ± 1.62 nm entrapment efficiency 93.14% 2.15%. Assessment indicated...
This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release double coated microparticles dependent on time pH. At pH 7.4 maximum observed for 6 h. efficiency coat to target colonic tissues confirmed using real-time X-ray radiography iohexol dye. Entrapment particle size were used characterization formula. Cytotoxicity HCT-116 cells significantly...
Background and Aim: Flibanserin (FLB) is a multifunctional serotonergic agent used for treating hypoactive sexual desire disorder in premenopausal women via oral administration. FLB has reported limited bioavailability of 33% that could be attributed to the drug's first-pass metabolism. In addition, pH-dependent solubility challenging factor drug dissolution body neutral fluid, consequently, absorption mucosal barriers. Thus, this work aims at investigating potential utilizing nanostructured...
Breast cancer is a dangerous type of in women. Quercetin (QRT), naturally occurring flavonoid, has wide biological effects including antioxidant, anticarcinogenic, anti-inflammatory, antiallergic, and antiviral activities. The anticancer activity considered the most valuable effect QRT against several types cancer, prostate, liver, lung, colon, breast cancer. Scorpion venom peptides (SV) been found to induce apoptosis aggravate cells, making it promising agent. QRT, SV, Phospholipon® 90H...
The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. objective current work was to evaluate efficacy combined complex Sitagliptin (SIT) with melittin (MEL) against SARS-CoV-2 virus. SIT-MEL nano-conjugates were optimized by a full three-factor bi-level (23) factorial design. In addition, SIT concentration (mM, X1), MEL X2), pH (X3) selected as critical factors. Particle size (nm, Y1) zeta potential (mV, Y2) assessed responses. Characterization...
Prostate cancer (PC) is emerging as one of the leading causes mortality and morbidity worldwide. Curcumin (CUR) a well-known phytochemical, scorpion venom (SV) natural peptide with proven anticancer properties. However, these bioactive agents are limited by low solubility, bioavailability, poor thermal stability, short half-lives. Therefore, aim this study was to fabricate SV-conjugated CUR phytosomes promising functionalized nanovesicles assess their efficacy in human prostatic PC3 cells....
The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence cardiovascular disease in adulthood. To improve dosing accuracy facilitate determination regimens function body weight, proposed study aims at preparing transdermal niosomal gels simvastatin possible drug delivery system pediatric applications. Twelve formulations were prepared to screen influence formulation processing variables on critical characteristics. Nano-sized niosomes...
Alendronate sodium (ALS) is the most common drug used for treatment of osteoporosis. The challenges facing ALS use include: very poor oral bioavailability (0.6%), esophageal ulcers, and complicated instructions its use. objective this research to utilize nanotechnology formulate into enteric-coated nanoliposomes (NLS) overcome previously mentioned drawbacks.NLS were prepared with lipid components phosphatidylcholine (PC), cholesterol (CH), lecithin (Lec) in ratios 4:1:1, 4:2:1, 4:3:1, 4:4:1,...