A5019337397- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Aortic Thrombus and Embolism
- Atherosclerosis and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
- Advanced Drug Delivery Systems
- Genetic factors in colorectal cancer
- Health Systems, Economic Evaluations, Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Nigella sativa pharmacological applications
- Hematological disorders and diagnostics
- Blood Pressure and Hypertension Studies
- Advancements in Transdermal Drug Delivery
- Dermatological and Skeletal Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Medicinal Plants and Neuroprotection
- RNA and protein synthesis mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Neutropenia and Cancer Infections
- Lipid Membrane Structure and Behavior
- Peptidase Inhibition and Analysis
- Curcumin's Biomedical Applications
King Abdulaziz University
2016-2025
University of Jeddah
2022-2024
National Guard Health Affairs
2023
King Abdullah International Medical Research Center
2023
King Saud bin Abdulaziz University for Health Sciences
2023
King Abdulaziz Medical City
2023
European Atherosclerosis Society
2021
McGill University
2008-2019
Université de Montréal
2011-2017
Montreal Clinical Research Institute
2011-2017
Proprotein convertase subtilisin/kexin 9 (PCSK9) promotes the degradation of low-density lipoprotein receptor (LDLR), and its gene is third locus implicated in familial hypercholesterolemia. Herein, we investigated role PCSK9 adipose tissue metabolism.At 6 months age, Pcsk9(-/-) mice accumulated ≈80% more visceral than wild-type mice. This was associated with adipocyte hypertrophy increased vivo fatty acid uptake ex triglyceride synthesis. Moreover, also observed Ldlr(-/-) mice, indicating...
Although statin therapy is known to increase concentrations of PCSK9, whether this effect related the magnitude LDL reduction uncertain. This study was undertaken understand extent and examine relationship between PCSK9 cholesterol (LDL-C) reduction.We measured plasma by ELISA at baseline 1 year in 500 men women participating Justification for Use Statins Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial that randomly allocated participants rosuvastatin 20 mg daily or...
Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for potential in drug delivery of agents. Thus, the purpose this study was determine enhancement ICA cytotoxicity activity OVCAR-3 via its formulation phytosomes. ICA-phytosomal optimized using Box–Behnken design. Particle size, shape, vitro release were used characterize...
Thymoquinone (TQ), a natural polyphenol, has been associated with various pharmacological responses; however, low bioavailability of TQ limits its clinical application. Thus, novel phytosomal delivery system TQ-Phospholipon® 90H complex (TQ-phytosome) was developed by refluxing combined anti-solvent precipitation. This optimized three-factor, three-level Box-Behnken design. The TQ-phytosome size (45.59 ± 1.82 nm) and the vesicle confirmed transmission electron microscopy. in vitro release...
The emergence of the SARS-CoV-2 pandemic has prompted scientists to search for an efficient antiviral medicine overcome rapid spread and marked increase in number patients worldwide. In this regard natural products could be a potential source substances active against coronavirus infections. A systematic computer-aided virtual screening approach was carried out using commercially available found on Zinc Database addition in-house compound library identify product inhibitors main protease...
Chronic kidney disease (CKD) is a prevalent global health issue affecting millions of patients worldwide, impacting quality life, impeding physical and psychological well-being, causing financial stress, increasing mortality rates. This study aimed to highlight the prevalence CKD its associated risk factors across Saudi Arabia. cross-sectional conducted from 2015 2022, using data 42 branches major network diagnostic laboratories in Arabia, covering country's 13 administrative areas. The mean...
AbstractFamilial hypercholesterolemia (FH) is an autosomal codominant lipoprotein disorder characterized by elevated low-density cholesterol (LDL-C) and high risk of premature atherosclerotic cardiovascular disease. Definitions for FH rely on complex algorithms that are the basis levels total or LDL-C, clinical features, family history, DNA analysis often difficult to obtain. We propose a novel simplified definition FH. Definite includes: (1) LDL-C (≥ 8.50 mmol/L); (2) ≥ 5.0 mmol/L (for age...
Lipids are central in the development of cardiovascular disease, and present study aimed to characterize variation lipid profiles across different countries improve understanding risk opportunities for risk-reducing interventions.
Worldwide, huge amounts of plastics are being introduced into the ecosystem, causing environmental pollution. Generally, plastic biodegradation in ecosystem takes hundreds years. Hence, isolation plastic-biodegrading microorganisms and finding optimum conditions for their action is crucial. The aim current study to isolate fungi explore action. Soil samples were gathered from landfill sites; 18 isolates able grow on SDA. Only 10 degrade polyvinyl chloride (PVC) polymer. Four displayed...
Patients with homozygous familial hypercholesterolemia (hmzFH) attributable to LDL receptor gene mutations have shown a remarkable increase in survival over the last 20 years. Early onset coronary heart disease (CHD) and calcific aortic valve stenosis are major complications of this disorder. We now report extensive premature calcification aorta patients hmzFH.We examined 25 hmzFH from Canada; mean age was 32 years (range 5 54), baseline cholesterol before treatment 19+/-5 mmol/L (737+/-206...
The management of hepatocellular carcinoma (HCC) is limited by the lack adequate screening biomarkers and chemotherapy. In response, there has been much interest in tumor metabolism as a therapeutic target. PCSK9 stimulates internalization LDL-receptor, decreases cholesterol uptake into hepatocytes affects liver regeneration. Thus, we investigated whether expression altered HCC, influencing its ability to harness metabolism. Thirty-nine patients undergoing partial hepatectomy or...
Piceatannol (PIC), a naturally occurring polyphenolic stilbene, has pleiotropic pharmacological activities. It reported cytotoxic activities against different cancer cells. In the present study, PIC emulsomes (PIC-E) were formulated and assessed for activity. A Box-Behnken design was employed to investigate influence of formulation factors on particle size drug entrapment. After optimization, had spherical shape with 125.45 ± 1.62 nm entrapment efficiency 93.14% 2.15%. Assessment indicated...
Background and Aim: Flibanserin (FLB) is a multifunctional serotonergic agent used for treating hypoactive sexual desire disorder in premenopausal women via oral administration. FLB has reported limited bioavailability of 33% that could be attributed to the drug's first-pass metabolism. In addition, pH-dependent solubility challenging factor drug dissolution body neutral fluid, consequently, absorption mucosal barriers. Thus, this work aims at investigating potential utilizing nanostructured...