A5086001522- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Growth Hormone and Insulin-like Growth Factors
- Nuclear Structure and Function
- Thyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Healthcare Regulation
- Pituitary Gland Disorders and Treatments
- Public Health in Brazil
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mitochondrial Function and Pathology
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Effects of Exercise
- Academic Research in Diverse Fields
- HIV-related health complications and treatments
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Science and Education Research
- PARP inhibition in cancer therapy
- Thyroid Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Caveolin-1 and cellular processes
Hospital Universitário Walter Cantídio
2008-2024
Universidade Federal do Ceará
2008-2024
Unichristus
2020-2024
DASA (Brazil)
2020-2024
Insper
2024
Universidade de Fortaleza
2023-2024
Universidade de São Paulo
2017-2022
Hospital São Paulo
2017
Universidade Estadual de Campinas (UNICAMP)
2016-2017
Sociedade Brasileira de Oncologia Clínica
2017
Lipids are central in the development of cardiovascular disease, and present study aimed to characterize variation lipid profiles across different countries improve understanding risk opportunities for risk-reducing interventions.
Justificativas A revisao da necessidade do jejum para determinacao perfil lipidico (colesterol total, LDL-C, HDL-C, nao-HDL-C e triglicerides [TG]) baseia-se nas seguintes justificativas: […] Posicionamento sobre a Flexibilizacao Jejum o Perfil Lipidico
Introdução A hipercolesterolemia familiar (HF) é uma causa genética comum de doença coronariana prematura, especialmente infarto do miocárdio, devido à exposição ao longo da vida a concentrações elevadas colesterol lipoproteína baixa densidade (LDL-c). Caracteriza-se por ser forma grave dislipidemia base genética, em que aproximadamente 85% dos homens e 50% das mulheres podem ter um evento coronariano antes completar os 65 anos idade, se não tratados adequadamente. HF considerada [...]
Sitosterolemia is a rare autosomal recessive disorder caused by homozygous or compound heterozygous variants in ABCG5/ABCG8. The disease characterized increased plasma plant sterols. Small case series suggest that patients with sitosterolemia have wide phenotypic heterogeneity great variability on either cholesterol levels development of atherosclerotic cardiovascular disease. present study aims to characterize the prevalence and clinical features participating familial hypercholesterolemia...
Metabolic abnormalities in congenital generalized lipodystrophy (CGL) are associated with microvascular complications. However, the evaluation of different types neuropathy these patients, including commitment cardiovascular autonomic modulation, is scarce. The objective present study was to determine prevalence (CAN) patients CGL compared individuals type 1 diabetes and healthy subjects. Ten CGL, 20 subjects were included study. Controls paired 1:2 for age, gender, BMI pubertal stage. Heart...
Carta de Apresentação A síndrome da quilomicronemia familiar (SQF) é uma forma grave dislipidemia e compreende um conjunto múltiplos sinais sintomas causados pela deficiência enzima lipoproteína lipase (LPL) ou seus cofatores, comprometendo o metabolismo triglicérides. Apresenta modo herança autossômico recessivo acomete cerca 1 a 2 pessoas por milhão indivíduos, mas pode ser mais frequente quando existe consanguinidade. Existe grande desconhecimento sobre essa condição e, esse motivo, [...]
Congenital generalized lipodystrophy (CGL) is a rare disorder characterized by the absence of subcutaneous adipose tissue, severe insulin resistance, diabetes mellitus, and cardiovascular complications, including cardiac autonomic neuropathy (CAN), left ventricular hypertrophy (LVH), atherosclerosis. The present study aimed to access association between CAN parameters abnormalities in CGL patients. A cross-sectional was conducted with 10 patients 20 healthy controls matched for age, sex,...
OBJECTIVE: To report the clinical and molecular aspects of a patient with diagnosis Resistance to Thyroid Hormone (RTH) harboring E449X mutation associated autoimmune thyroid disease severe neuropsychomotor retardation. METHODS: We present case including laboratory findings, analysis Brazilian RTH. RESULTS: A 23-year old male presented hyperactivity disorder, attention deficit, delayed development, goiter. Since age 1 year 8 months, his mother had sought medical care for her son...
Objective This study aimed to determine the thyroid-stimulating hormone (TSH) reference interval (RI) and assess influence of use thyroid ultrasonography (TUS) on individual selection from a healthy adult population in Fortaleza, Brazil. Subjects methods cross-sectional recruited patients (N = 272; age 18-50 years) with normal function (NTF) placed them three groups according their test results: NTF (n all participants), TUS 170; participants who underwent US), RI 124; individuals TSH...
Previous studies suggest intestinal dysbiosis is associated with metabolic diseases. However, the causal relationship between them not fully elucidated. Gut microbiota evaluation of patients congenital generalized lipodystrophy (CGL), a disease characterized by absence subcutaneous adipose tissue, insulin resistance, and diabetes since first years life, could provide insights into these relationships.A cross-sectional study was conducted CGL (n = 17) healthy individuals 17). The gut...
A premature myocardial infarction (PMI) is usually associated with a familial component. This study evaluated cardiovascular risk factors in first-degree relatives (FDR) of patients PMI not presenting the hypercholesterolemia phenotype. cross-sectional comprising FDR non-familial who suffered <45-years age matched for and sex individuals without family history disease. Subjects were presence metabolic syndrome its components, lifestyle, statin therapy, laboratory parameters. The sample was...
Hypertriglyceridemia (HTG) is a common dyslipidemia associated with an increased risk of cardiovascular disease and pancreatitis. It well stablished that the severe cases often present underlying genetic cause. In this study, we determined frequency variation spectrum genes involved in triglyceride metabolism series Brazilian patients HTG. A total 212 very high HTG, defined fasting triglycerides (TG) ≥ 880 mg/ dL, underwent multi-gene panel testing were included research. Germline...
Abstract Background Fulminant purpura is a clinical syndrome characterized by purplish, ischemic-looking skin rash, commonly accompanied systemic symptoms ranging from acute febrile to septic shock. Due high lethality of possible infectious etiologies, immediate recognition and early initiation empirical antimicrobial therapy are crucial ensure better outcomes. Interdisciplinary collaboration among healthcare teams, disease specialists microbiologists essential accurate microbiological...
Abstract Background Prolactin (PRL) exists in different forms human serum. The predominant form is monomeric PRL, the other include dimeric PRL and polymeric also known as macroprolactin, a biologically inactive form. Macroprolactin can be measured by almost all immunoassays for PRL. This may lead to misdiagnosis mismanagement of patients. Polyethylene glycol (PEG) precipitation most widely used method detecting generally employing cutoff 40% distinguish macroprolactinemia from true...