A5012474163- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Steroid Chemistry and Biochemistry
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Sodium Intake and Health
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015-2024
Universidade de São Paulo
2010-2020
Universidade Estadual de Campinas (UNICAMP)
2001-2020
Weatherford College
2020
Universidade Cidade de São Paulo
2019
Hospital Universitário da Universidade de São Paulo
2018
Hospital de Clínicas da Unicamp
2015
Centro Universitário das Faculdades Metropolitanas Unidas
2015
University of Beira Interior
2009
Cleveland Clinic
2001
In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-density lipoproteins and lower capacity high-density to remove cellular cholesterol. Studies in rodents showed that aging led cholesterol accumulation the liver decrease brain with reduced synthesis levels 24-hydroxylase, an enzyme responsible for removing from brain. Liver diseases are also related inducing changes metabolism rats. It has been suggested late onset Alzheimer's disease is associated...
The antioxidant activity of maté tea, the roasted product derived from yerba (Ilex paraguarienis), was observed in vitro and animal models, but studies humans are lacking. aim this study to investigate effects tea supplementation on plasma susceptibility oxidation enzyme gene expression healthy nonsmoking women, after acute or prolonged ingestion. We evaluated total status (TAS), kinetics diene conjugate generation, thiobarbituric acid reactive substance (TBARS) contents plasma, as well mRNA...
Background Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy traditional markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed potential marker. Hence, we investigate whether HDL improves predictive value HDL-cholesterol in identification carotid atherosclerotic burden individuals stratified be at LCR. Methods Findings 284 (40–75 years) classified LCR...
Sepsis is a systemic inflammatory response to infection eliciting high mortality rate which serious health problem. Despite numerous studies seeking for therapeutic alternatives, the mechanisms involved in this disease remain elusive. In study we evaluated influence of cholesteryl ester transfer protein (CETP), glycoprotein that promotes lipids between lipoproteins, on mice. Human CETP transgenic mice were compared control (wild type, WT) after polymicrobial sepsis induced by cecal ligation...
The involvement of the five thymidine (5T) variant in intron 8 cystic fibrosis membrane regulator (CFTR) gene congenital bilateral absence vas deferens (CBAVD) phenotype has been extensively demonstrated. This leads to alternative splicing CFTR which results a wild-type transcript and one without exon 9. Little is known about expression testis. We analysed level aberrantly spliced transcripts testicular biopsies correlated it with disease expression. Quantitative RT-PCR analysis from control...
Reduced estrogen levels result in loss of protection from coronary heart disease postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma cholesteryl ester transfer protein (CETP); however, little is known about the role CETP-ovarian hormone interactions atherogenesis. We assessed severity diet-induced ovariectomized (OV) CETP transgenic mice crossbred LDL receptor knockout mice. Compared OV expressing (+), non-expressing (−) had higher total, VLDL-,...
In this study we analyzed the role played by aerobic exercise training in plasma lipoprotein profile, prebeta 1-HDL concentration, and vitro HDL3 ability to remove cholesterol from macrophages inhibit LDL oxidation type 2 diabetes mellitus (DM) patients control subjects, fasting postprandial states. Healthy controls (HTC, N = 11; 1 M/10 F) subjects with (DMT, 3M/8F) were engaged a 4-month program, compared group of sedentary (DMS, 10; 4 M/6 F). All groups submitted an oral fat load test...
Serum concentrations of lathosterol, the plant sterols campesterol and sitosterol cholesterol metabolite 5α-cholestanol are widely used as surrogate markers synthesis absorption, respectively. Increasing numbers laboratories utilize a broad spectrum well-established recently developed methods for determination non-cholesterol (NCS). In order to evaluate quality these measurements identify possible sources analytical errors our group initiated first international survey NCS. The NCS was...
The antiatherogenic functions of high density lipoprotein (HDL-C) include its role in reverse cholesterol transport, but to what extent the concentration HDL-C interferes with whole-body metabolism is unknown. Therefore, we measured markers body synthesis (desmosterol and lathosterol) intestinal absorption (campesterol β-sitosterol) healthy subjects that differ according their plasma concentrations.Healthy participants presented either low (< 40 mg/dl, n=33, 17 male 16 female) or (> 60...
Abstract Background Advanced glycation end products (AGE) alter lipid metabolism and reduce the macrophage expression of ABCA-1 ABCG-1 which impairs reverse cholesterol transport, a system that drives from arterial wall macrophages to liver, allowing its excretion into bile feces. Oxysterols favors homeostasis in drive although accumulation 7-ketocholesterol, 7alpha- hydroxycholesterol 7beta- is related atherogenesis cell death. We evaluated effect glycolaldehyde treatment (GAD; oxoaldehyde...
Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility seasonal variations these parameters, which may cause under- or overestimation. Biological rhythms variation was investigated 227 359 consecutive who underwent health checkups primary care centers between 2008 2010. Plasma low-density lipoprotein cholesterol (LDL-C) >130 mg/dL 8%...
Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are autoimmune diseases have similar genetic patterns. T1DM treatment is based on diet, physical activity insulin therapy, whereas CD depends dietary changes with restriction of wheat, rye barley. The aim the study was to evaluate quality life (QoL) individuals association CD, characterize their nutritional status compare it those only one healthier controls.Sixty patients controlled by sex, age body mass index (BMI) were stratified...
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol oxysterol accumulation in macrophage foam cells. Soluble RAGE (sRAGE) impairs cellular AGE signaling alleviating the deleterious effects of atherogenesis. The association between plasma AGEs sRAGE with content cholesterol, markers synthesis absorption, oxysterols atherosclerotic plaques was evaluated subjects undergoing carotid endarterectomy.Plasma were obtained from...
Sitosterolemia is a rare autosomal recessive disorder caused by homozygous or compound heterozygous variants in ABCG5/ABCG8. The disease characterized increased plasma plant sterols. Small case series suggest that patients with sitosterolemia have wide phenotypic heterogeneity great variability on either cholesterol levels development of atherosclerotic cardiovascular disease. present study aims to characterize the prevalence and clinical features participating familial hypercholesterolemia...
Cholesterol undergoes oxidation via both enzymatic stress- and free radical-mediated mechanisms, generating a wide range of oxysterols. In contrast to oxidative stress-driven metabolites, stress-derived oxysterols are scarcely studied in their association with atherosclerotic disease humans.24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), 27-hydroxycholesterol (27-HC) were assessed plasma arteries plaques from 10 patients (54-84 years) severe peripheral artery (PAD) as well 13...
The association between plasma lipids and breast cancer (BC) has been extensively explored although results are still conflicting especially regarding the relationship with high-density lipoprotein cholesterol (HDLc) levels. HDL mediates oxysterol removal from cells limiting sterols necessary for tumor growth, inflammation, metastasis this may not be reflected by measuring HDLc. We addressed recently diagnosed, treatment-naïve BC women (n = 163), classified according to molecular types of...