A5074398405- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Diabetes Management and Education
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Nitric Oxide and Endothelin Effects
- Digestive system and related health
- Diet and metabolism studies
- Sulfur Compounds in Biology
- Pediatric Urology and Nephrology Studies
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Mobile Health and mHealth Applications
- Kidney Stones and Urolithiasis Treatments
Universidade Nove de Julho
2020-2024
Universidade de São Paulo
2008-2021
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2005-2020
Hospital Regional de Presidente Prudente
2016
Fundação Faculdade de Medicina
2015
Centro Universitário das Faculdades Metropolitanas Unidas
2012
Universidade Brasil
2008-2009
Case Western Reserve University
2002-2004
Dr. Euryclides Hospital de Jesus Zerbini
2004
Overweight and obesity in youth is a worldwide public health problem. childhood adolescents have substantial effect upon many systems, resulting clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidemia, hypertension type 2 diabetes (T2D). Obesity the of body fat distribution are still core aspects insulin resistance seem to be physiopathologic links common cardiovascular disease T2D. The earlier appearance clustering risk factors higher time exposure, greater will...
OBJECTIVE:To evaluate the impact of a clinical pharmacy program on health outcomes in patients with type 2 diabetes undergoing insulin therapy at teaching hospital Brazil.METHOD: A randomized controlled trial 6-month follow-up period was performed 70 adults, aged 45 years or older, who were taking and had an HbA1c level $8%.Patients control group (CG) (n = 36) received standard care, intervention (IG) 34) individualized pharmacotherapeutic care plan education.The primary outcome measure...
Abstract Background Oxidative stress is recognized as a major pathogenic factor of cellular damage caused by hyperglycemia. NOX/NADPH oxidases generate reactive oxygen species and NOX1, NOX2 NOX4 isoforms are expressed in kidney require association with subunit p22phox (encoded the CYBA gene). Increased expression was described animal models diabetic nephropathy. In opposite direction, glutathione one main endogenous antioxidants whose plasmatic concentrations were reported to be reduced...
Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are autoimmune diseases have similar genetic patterns. T1DM treatment is based on diet, physical activity insulin therapy, whereas CD depends dietary changes with restriction of wheat, rye barley. The aim the study was to evaluate quality life (QoL) individuals association CD, characterize their nutritional status compare it those only one healthier controls.Sixty patients controlled by sex, age body mass index (BMI) were stratified...
Aims: Thioredoxin interacting protein (TXNIP), an inhibitor of antioxidant thioredoxin (Trx), is upregulated by hyperglycemia and implicated in pathogenesis diabetes complications. We evaluated mRNA expressions genes encoding TXNIP Trx (TXN) urinary sediment peripheral blood mononuclear cells (PBMC) type 1 (T1D) patients with different degrees chronic Methods: qPCR was employed to quantify target (n = 55) PBMC 161) from sorted presence or absence diabetic nephropathy (DN), retinopathy,...
The aim of the present study was to determine prevalence celiac disease in children short stature and assess whether some routine laboratory examinations performed cause could suggest presence disease. A total 106 no gastrointestinal symptoms were studied. An extensive endocrine work-up had been negative for all them an additional investigation by measuring concentration antiendomysial antibody. Patients who positive antibody ( > or = 1:10) exhibited IgA deficiency (less than 5 mg/dl)...
OBJECTIVE To compare the serum micro-RNAs (miRNAs) profile of individuals with type 1 diabetes without microvascular complications versus those multiple severe complications, in order to identify epigenetically modulated pathways these two groups individuals. RESEARCH DESIGN AND METHODS A total 10 subjects was selected among followed Diabetes Outpatient Clinic and sorted according absence or presence all complications. Samples from participants were used for evaluation miRNA expression...
Oxidative stress is involved in the pathophysiology of diabetic nephropathy. The superoxide-generating nicotinamide adenine dinucleotide phosphate-oxidase 2 (NOX2, encoded by CYBB gene) and antioxidant enzyme glutathione peroxidase 4 (GPX4) play opposing roles balance cellular redox status. In present study, we investigated associations single nucleotide polymorphisms (SNPs) regulatory regions GPX4 with kidney disease patients type 1 diabetes. Two functional SNPs, rs6610650 (CYBB promoter...
Objective: To investigate the association between inadequate functional health literacy, considering Short Assessment of Health Literacy for Portuguese-speaking Adults, and glycemic control in elderly patients with type 2 diabetes, to examine this low social support settings, according Medical Outcomes Study . Methods: Cross-sectional study conducted at diabetes referral center a university hospital. Participants were recruited among aged 60 years or older, May 2013 November 2014. The [...]
Quantitative polymerase chain reaction was employed to quantify expression of two genes coding for advanced glycation end-product receptors [RAGE ( AGER) and AGER1 DDOST)] the gene deacetylase SIRT1 SIRT1) in peripheral blood mononuclear cells from type 1 diabetes patients without [Group A, n = 35; 28.5 (24–39) years old; median (interquartile interval)] or with at least one microvascular complication B, 117; 34.5 (30–42) old]; 31 healthy controls were also included. In a subgroup 48...
Maturity-onset diabetes of the young (MODY) is characterized by an autosomal dominant mode inheritance, early onset hyperglycemia, and defects insulin secretion. MODY subtypes described present genetic, metabolic, clinical differences. 2 mild asymptomatic fasting rarely requires pharmacological treatment. Hence, precise diagnosis important for determining management prognosis. We report two heterozygous GCK mutations identified during investigation short stature. Case 1: a prepubertal...
Screen time (ST) has shown negative effects on physical and mental health, with an increase in the prevalence of overweight, metabolic syndrome (MetS), obesity. The spent front screens was also associated higher odds selecting indicators cardiometabolic disease adulthood. In view this, aim this study to identify risk MetS type 2 diabetes mellitus (T2DM) healthy young males relate it ST sleep time.
Thyroid hormones (triiodothyronine [T3] and thyroxine [T4]) stimulate UCP-3 expression in skeletal muscle. We examined whether thyroid hormone-induced changes uncoupling protein (UCP)-3 mRNA are related to directs effects of T3 or reflect secondary the hormone through stimulation renin-angiotensin β-adrenergic systems. Hyperthyroidism was produced by three injections 100 μg T3/100 g body weight on alternate days with without concomitant treatment either captopril (an angiotensin-converting...
Abstract Background and aims Diabetic kidney disease (DKD) is associated with lipid derangements that worsen function enhance cardiovascular (CVD) risk. The management of dyslipidemia, hypertension other traditional risk factors does not completely prevent CVD complications, bringing up the participation nontraditional such as advanced glycation end products (AGEs), carbamoylation changes in HDL proteome functionality. composition, proteome, chemical modification functionality were analyzed...