A5031769785- Cholesterol and Lipid Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Glycation End Products research
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Lipid metabolism and disorders
- Sodium Intake and Health
- Lipid metabolism and biosynthesis
- Chronic Kidney Disease and Diabetes
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Steroid Chemistry and Biochemistry
- Blood Pressure and Hypertension Studies
- Alcohol Consumption and Health Effects
- Cardiovascular Health and Disease Prevention
- Antioxidant Activity and Oxidative Stress
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2010-2024
Universidade de São Paulo
2011-2022
Companhia Energética de São Paulo
2020
Universidade Estadual de Campinas (UNICAMP)
2015
Universidade Brasil
2000-2009
Hospital São Paulo
2007
Hospital Universitário da Universidade de São Paulo
1997
In this study, we analyzed the effect of aerobic exercise training (AET) and a single bout on plasma oxidative stress antioxidant defenses in type 2 diabetes mellitus (DM) healthy control subjects (C). DM C did not differ regarding triglycerides, high‐density lipoprotein cholesterol (HDL‐c), insulin, HOMA index at baseline after AET. To measure lag time for low‐density (LDL) oxidation (LAG) maximal rate conjugated diene formation (MCD), participants' HDL 3 were incubated with LDL from pooled...
Background Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy traditional markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed potential marker. Hence, we investigate whether HDL improves predictive value HDL-cholesterol in identification carotid atherosclerotic burden individuals stratified be at LCR. Methods Findings 284 (40–75 years) classified LCR...
ALP -fosfatase alcalinaALT -alanina aminotransferase AMPK -proteína adenosina
Abstract Background We evaluated the effects of albumin isolated from control individuals and patients with poorly controlled type 1 diabetes mellitus on macrophage gene expression reverse cholesterol transport. Methods Serum was purified subjects ( n = 12) 13). 14 C‐cholesterol‐labelled J774 macrophages treated were employed to measure efflux mediated by apo A‐I, HDL 3 or 2 , intracellular lipid accumulation cellular ABCA‐1 protein content. Agilent arrays (44000 probes) used analyse...
The aim of this study was to evaluate extracellular matrix components in articular cartilage, ligaments and synovia an experimental model diabetes. Young Wistar rats were divided into a streptozotocin-induced (STZ; 35 mg/kg) diabetic group (DG; n=15) control (CG; n=15). Weight, blood glucose plasma anti-carboxymethyllysine measured 70 days after STZ infusions. Knee joints, patellar ligaments, lateral medial collateral isolated stained with hematoxylin-eosin Picrosirius. total collagen...
Background Bezafibrate (BZF) is effective in the treatment of hypertriglyceridemia human patients, but there are no data on its use dogs. Objective To assess safety BZF hyperlipidemic dogs and efficacy decreasing serum triglyceride (TG) cholesterol (CHO) concentrations. Animals Forty‐six dogs, 26 females 20 males, mean (±SD) age 9 (±3) years, with TG ≥150 mg/dL (33 also were hypercholesterolemic [>300 mg/dL]). Methods Prospective, uncontrolled clinical trial. Dogs treated bezafibrate once...
Fibrinogen is a cardiovascular risk factor, but little known about levels in ethnic groups that differ their risk. was measured 479 Black individuals, 459 South Asian Indians, and 453 Whites aged 40–59 years living south London, England, from March 1994 to July 1996. Genotype determined at two sites the promoter of β-fibrinogen gene (G-455→A C-148→T). Plasma fibrinogen were lower Blacks than by 0.22 g/liter (95% confidence interval (CI): 0.08, 0.36) men 0.11 CI: –0.01, 0.23) women. These...
In this study we analyzed the role played by aerobic exercise training in plasma lipoprotein profile, prebeta 1-HDL concentration, and vitro HDL3 ability to remove cholesterol from macrophages inhibit LDL oxidation type 2 diabetes mellitus (DM) patients control subjects, fasting postprandial states. Healthy controls (HTC, N = 11; 1 M/10 F) subjects with (DMT, 3M/8F) were engaged a 4-month program, compared group of sedentary (DMS, 10; 4 M/6 F). All groups submitted an oral fat load test...
Advanced glycation end products (AGE) are elevated in diabetes mellitus (DM) and predict the development of atherosclerosis. AGE-albumin induces oxidative stress, which is linked to a reduction ABCA-1 cholesterol efflux. We characterized level human serum albumin (HSA) isolated from poorly controlled DM2 (n = 11) patients compared with that control (C, n 12) individuals determined mechanism by DM2-HSA can interfere macrophage lipid accumulation. The HSA was analyzed MALDI/MS. Macrophages...
The antiatherogenic functions of high density lipoprotein (HDL-C) include its role in reverse cholesterol transport, but to what extent the concentration HDL-C interferes with whole-body metabolism is unknown. Therefore, we measured markers body synthesis (desmosterol and lathosterol) intestinal absorption (campesterol β-sitosterol) healthy subjects that differ according their plasma concentrations.Healthy participants presented either low (< 40 mg/dl, n=33, 17 male 16 female) or (> 60...
Abstract Background Advanced glycation end products (AGE) alter lipid metabolism and reduce the macrophage expression of ABCA-1 ABCG-1 which impairs reverse cholesterol transport, a system that drives from arterial wall macrophages to liver, allowing its excretion into bile feces. Oxysterols favors homeostasis in drive although accumulation 7-ketocholesterol, 7alpha- hydroxycholesterol 7beta- is related atherogenesis cell death. We evaluated effect glycolaldehyde treatment (GAD; oxoaldehyde...
ATP-binding cassette transporter A1 mediates the export of excess cholesterol from macrophages, contributing to prevention atherosclerosis. Advanced glycated albumin (AGE-alb) is prevalent in diabetes mellitus and associated with development Independently changes ABCA-1 mRNA levels, AGE-alb induces oxidative stress reduces protein which leads macrophage lipid accumulation. These metabolic conditions are known elicit endoplasmic reticulum (ER) stress. We sought determine if ER unfolded...
Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility seasonal variations these parameters, which may cause under- or overestimation. Biological rhythms variation was investigated 227 359 consecutive who underwent health checkups primary care centers between 2008 2010. Plasma low-density lipoprotein cholesterol (LDL-C) >130 mg/dL 8%...
Regular exercise prevents and regresses atherosclerosis by improving lipid metabolism antioxidant defenses. Exercise ameliorates the reverse cholesterol transport (RCT), an antiatherogenic system that drives from arterial macrophages to liver for excretion into bile feces. In this study we analyzed role of aerobic on in vivo RCT expression genes proteins involved flux inflammation peritoneal macrophages, aortic arch wild type mice. Twelve-week-old male mice were divided sedentary trained...