A5044148338- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Public Health in Brazil
- Healthcare Regulation
- Cholesterol and Lipid Metabolism
- Lipid metabolism and disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Imaging and Diagnostics
- Healthcare during COVID-19 Pandemic
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Aortic Thrombus and Embolism
- Pancreatic and Hepatic Oncology Research
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Antioxidant Activity and Oxidative Stress
- Coronary Interventions and Diagnostics
- Youth, Drugs, and Violence
- Diabetes Treatment and Management
- Cardiovascular Effects of Exercise
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Agricultural and Food Sciences
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
1999-2024
Universidade de São Paulo
2013-2024
Hospital São Paulo
2007-2023
Discovery Air (Canada)
2022
Hospital do Coração
2013-2021
Sociedade Brasileira de Cardiologia
2007
Characterize homozygous familial hypercholesterolemia (HoFH) individuals from Iberoamerica. Approach and Results: In a cross-sectional retrospective evaluation 134 with HoFH phenotype, 71 adults (age 39.3±15.8 years, 38.0% males), 63 children 8.8±4.0 50.8% males) were studied. Genetic characterization was available in 129 (96%). The majority (91%) true homozygotes (true HoFH, n=79, 43.0% children, 46.8% or compound heterozygotes (compound heterozygous hypercholesterolemia, n=39, 51.3% 46.2%...
Introdução A hipercolesterolemia familiar (HF) é uma causa genética comum de doença coronariana prematura, especialmente infarto do miocárdio, devido à exposição ao longo da vida a concentrações elevadas colesterol lipoproteína baixa densidade (LDL-c). Caracteriza-se por ser forma grave dislipidemia base genética, em que aproximadamente 85% dos homens e 50% das mulheres podem ter um evento coronariano antes completar os 65 anos idade, se não tratados adequadamente. HF considerada [...]
Sitosterolemia is a rare autosomal recessive disorder caused by homozygous or compound heterozygous variants in ABCG5/ABCG8. The disease characterized increased plasma plant sterols. Small case series suggest that patients with sitosterolemia have wide phenotypic heterogeneity great variability on either cholesterol levels development of atherosclerotic cardiovascular disease. present study aims to characterize the prevalence and clinical features participating familial hypercholesterolemia...
We evaluated the effects of defatted amaranth (Amaranthus caudatus L.) snacks on plasma lipids in moderate hypercholesterolemic patients. Twenty-two subjects [30-65 years old), 11 males, with total cholesterol (TC) > 240 mg.dL-1, low-density (LDL-c) 160-190 mg.dL-1 and triglycerides (TG) < 400 mg.dL-1] were randomized a double blind clinical trial to receive an snack (50 g/day) or equivalent corn (placebo) for 2 months. There no differences between placebo TC LDL-c, TG respectively: -8.4...
Abstract The objective of this study was to evaluate the kinetics both free and esterified forms cholesterol contained in a emulsion that binds LDL receptors (LDE) subjects with heterozygous familial hypercholesterolemia (FH), same under effects high‐dose simvastatin treatment, as compared control normolipidemic group (NL). Twentyone FH patients (44.0±13.0 yr, 12 females, levels 6.93±1.60 mmol/L) 22 (44.0±15.0, 10 3.15±0.62 were injected intravenously 14 C‐cholesteryl ester 3 H‐cholesterol....
During hypoxia, active substances released by the endothelium play a key role in cardiovascular and respiratory responses elicited to optimize oxygen delivery. As hypercholesterolemia is major cause of endothelial dysfunction, it may interfere with these responses.We studied ventilatory acute systemic hypoxia 14 patients (HC) 13 control (CO) subjects. Oxygen saturation decreased similarly both groups. Diastolic blood pressure increased only HC group (P=0.0002) and, despite systolic increases...
The platelet indices Mean Platelet Volume (MPV), Distribution Width (PDW) and Plate-letcrit (PCT) provided by automated hematology analysis are rarely used in clinical practice. Platelets play a central role the pathogenesis of acute coronary syndromes (ACS) high MPV has been associated to more reactive platelets regarded as an independent risk factor for myocardial infarction. In this study, were evaluated 39 patients with ACS presenting two altered biochemical parameters, C protein (CRP)...
Carta de Apresentação A síndrome da quilomicronemia familiar (SQF) é uma forma grave dislipidemia e compreende um conjunto múltiplos sinais sintomas causados pela deficiência enzima lipoproteína lipase (LPL) ou seus cofatores, comprometendo o metabolismo triglicérides. Apresenta modo herança autossômico recessivo acomete cerca 1 a 2 pessoas por milhão indivíduos, mas pode ser mais frequente quando existe consanguinidade. Existe grande desconhecimento sobre essa condição e, esse motivo, [...]
Metabolic syndrome (MetS) refers to states of insulin resistance that predispose development cardiovascular disease and type 2 diabetes (T2DM). The aim was investigate whether plasma lipids lipid metabolism differ in MetS patients compared those with T2DM poor glycemic control (glycated hemoglobin > 7.0). Eighteen T2DM, 18 14 controls, paired for age (40-70 years) body mass index (BMI), were studied. Plasma the kinetics a triacylglycerol-rich emulsion labeled [(3)H]-triolein ([(3)H]-TAG)...