A5066704481- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Public Health in Brazil
- Diet and metabolism studies
- Healthcare Regulation
- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
- Obstructive Sleep Apnea Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular and exercise physiology
- Sodium Intake and Health
- Cardiac, Anesthesia and Surgical Outcomes
- Youth, Drugs, and Violence
- Adipose Tissue and Metabolism
- Trypanosoma species research and implications
- Heart Failure Treatment and Management
- Health Education and Validation
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Cardiovascular Syncope and Autonomic Disorders
Universidade de São Paulo
2014-2024
Hospital do Rim e Hipertensão
2001-2024
Centro Universitário UNINOVAFAPI
2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2001-2022
Universidade Nove de Julho
2015-2021
Instituto do Coração
2021
University of South Carolina
2021
Hospital Universitário da Universidade de São Paulo
2020
Centre d’Infectiologie Christophe Mérieux of Laos
2019
Universidade Federal do Piauí
2018
Background Obstructive Sleep Apnea (OSA) is tightly linked to some components of Metabolic Syndrome (MetS). However, most the evidence evaluated individual MetS or patients with a diagnosis OSA that were referred for sleep studies due complaints. Therefore, it not clear whether exacerbates metabolic abnormalities in representative sample MetS. Methodology/Principal Findings We studied 152 consecutive (age 48±9 years, body mass index 32.3±3.4 Kg/m2) newly diagnosed (Adult Treatment Panel...
Evidence suggests that obesity may raise blood pressure (BP) through oxidative stress–sensitive mechanisms and the Dietary Approaches to Stop Hypertension combination diet (DASH-CD) decrease BP by enhancing antioxidant capacity. To address this question, 12 obese patients with high-normal–to–stage 1 hypertension (hypertensives) lean normotensives were studied on their usual diets after following DASH-CD a low-antioxidant in random sequence for 4 weeks each. Acute stress was induced 4-hour...
BACKGROUND. Metabolic syndrome (MetS) is an obesity-driven condition of pandemic proportions that increases the risk type 2 diabetes and cardiovascular disease. Pathophysiological mechanisms are poorly understood, though inflammation has been implicated in MetS pathogenesis. The aim this study was to assess effects galantamine, a centrally acting acetylcholinesterase inhibitor with antiinflammatory properties, on markers insulin resistance risk, other metabolic indices subjects MetS.
1. Definition of the Problem […] 3rd Guideline for Perioperative Cardiovascular Evaluation Brazilian Society Cardiology
Evidence suggests lipid abnormalities may contribute to elevated blood pressure, increased vascular resistance, and reduced arterial compliance among insulin-resistant subjects. In a study of 11 normal volunteers undergoing 4-h-long infusions Intralipid heparin raise plasma nonesterified fatty acids (NEFAs), we observed increases pressure. contrast, pressure did not change in these same during 4-h infusion saline heparin. To better characterize the hemodynamic responses heparin, another...
Truck drivers work under conditions that predispose them to a high prevalence of risk factors for the development cardiovascular disease (CVD); however, these have not been fully evaluated and are usually considered be within scope health or labor services. An observational cross-sectional study was conducted on 250 long-distance truck drivers; were all male aged 18-60 years. The clinical evaluation consisted an assessment social habits demographic data CVD at 3 time points separated by...
Background: The metabolic syndrome (MetS) is an obesity-associated disorder of pandemic proportions and limited treatment options. Oxidative stress, low-grade inflammation altered neural autonomic regulation, are important components drivers pathogenesis. Galantamine, acetylcholinesterase inhibitor a cholinergic drug that clinically-approved (for Alzheimer's disease) has been implicated in regulation several conditions characterized with immune derangements. Here we examined the effects...
Objective To determine whether raised concentrations of non-esterified fatty acids (NEFAs) may contribute to the cardiovascular risk factor cluster by increasing oxidative stress in vivo. Design and Methods Plasma urine F2-isoprostanes, biomarkers stress, were measured after an overnight fast during a 4 h infusion Intralipid heparin increase NEFAs 10 obese hypertensive patients with 12 healthy normotensive individuals without evidence insulin resistance. A time-control group nine received...
Obstructive sleep apnea (OSA) and the metabolic syndrome (MS) are independently associated with increased cardiovascular risk. The objective of present study was to determine prevalence OSA among consecutive patients MS whether is impaired glycemic control. Fifty a recent diagnosis no previous underwent polysomnography anthropometric laboratory measurements. (apnea‐hypopnea index ≥15 events per hour sleep) 68% in same range all other individual components MS. Moreover, levels glucose ( P...
Tabela 2 -Estratificação de risco cardíaco para procedimentos não cardíacos Alto (Risco ≥ 5,0%) Cirurgias vasculares (aórtica, grandes vasos, vascular periférica) urgência ou emergência Intermediário 1,0% e < Endarterectomia carótida correção endovascular aneurisma aorta abdominal Cirurgia cabeça pescoço intraperitoneais intratorácicas ortopédicas prostáticas Baixo 1,0%) Procedimentos endoscópicos superficiais
Whether sex influences the association of obstructive sleep apnea ( OSA ) with markers cardiovascular risk in patients hypertension is unknown. In this study, 95 hypertensive participants underwent carotid‐femoral pulse wave velocity, 24‐hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30‐day standardized treatment hydrochlorothiazide plus enalapril or losartan. was present 52 patients. Compared non‐ patients, velocity values were higher group (men:...
Malignant hypertension is a serious form of arterial in which the physiopathological mechanisms include increased activity sympathetic nervous system, renin angiotensin and endothelium dysfunction. Family history an important predictive factor for associated with metabolic hemodynamic abnormalities. Studies these abnormalities malignant hypertensive offspring have not yet been published. Therefore, we studied 42 parents (OMH group: age, 22+/-7 years; 23 male subjects; 27 white) 35...
Although a slightly elevated office blood pressure (BP) has been reported in several studies, little is known about the prolonged resting pressure, heart rate (HR) and baroreflex sensitivity (BRS) of prehypertensive subjects with family history hypertension. Office (1 h) BP HR were measured 25 young normotensives positive hypertension (FH+) negative (FH-), matched for age, sex, body mass index. After measurements, samples collected determination norepinephrine, plasma renin activity...
Oxidative stress emerges as a potential factor in the pathogenesis of hypertension and common signal transduction mechanism by which various risk factors mediate cardiovascular renal disease. A greater level oxidative could contribute to higher rates related complications African Americans than white Americans. The objective this study was compare induced standardized episode acute hyperlipidemia two groups. Fifteen (37 ± 1 years, 9 women/6 men, body mass index 30 2 kg/m2) 15 whites (38 27...
More recently, the association of different risk factors has been described as metabolic syndrome. Different definitions are being used for same Regardless name or classification, it well established that a cardiovascular cluster including overweight/obesity, increased blood pressure, and lipid glucose abnormalities associated with an atherosclerosis in adults.The aim this study was to correlate body mass index percentiles insulin resistance index, profiles children adolescents, which...
OBJECTIVES:The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days life. METHOD:The animals were assigned control (control, n = 10) and (monosodium glutamate, 13) groups.Thirty-three weeks after birth, arterial venous catheters implanted for pressure measurements, drug administration, blood sampling.Baroreflex sensitivity evaluated according tachycardic bradycardic responses...
The autonomic nervous system plays an important role in physiological and pathological conditions, has been extensively evaluated by parametric non-parametric spectral analysis. To compare the results obtained with fast Fourier transform (FFT) autoregressive (AR) method, we performed a comprehensive comparative study using data from humans rats during pharmacological blockade (in rats), postural test humans), hypertensive state both rats). Although hypotension induced increase normalized...