A5066610145- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Diet, Metabolism, and Disease
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Exercise and Physiological Responses
- Vagus Nerve Stimulation Research
- Muscle metabolism and nutrition
- Cardiovascular Effects of Exercise
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Health and Lifestyle Studies
- Healthcare Regulation
- Laser Applications in Dentistry and Medicine
- High Altitude and Hypoxia
- Cardiovascular Health and Risk Factors
- Nitric Oxide and Endothelin Effects
- Non-Invasive Vital Sign Monitoring
- Heart rate and cardiovascular health
Universidade Federal de São Paulo
2007-2025
Universidade Nove de Julho
2016-2025
Fundação de Apoio à Universidade Federal de São Paulo
2022-2024
Union des Industries Ferroviaires Européennes
2020
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2004-2019
Universidade de São Paulo
2004-2018
Universidade São Judas Tadeu
2004-2018
Universidade Federal do Maranhão
2018
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2009-2018
Instituto do Coração
2018
Abstract Background The aim of the present study was to investigate relationship between speed during maximum exercise test (ET) and oxygen consumption (VO 2 ) in control STZ-diabetic rats, order provide a useful method determine capacity prescription researches involving rats. Methods Male Wistar rats were divided into two groups: (CG, n = 10) diabetic (DG, 8). animals submitted ET on treadmill with simultaneous gas analysis through open respirometry system. VO assessed 60 days after...
Increase in oxidative/nitrosative stress is one of the mechanisms associated with development cardiotoxicity due to doxorubicin (Dox), a potent chemotherapy drug. Previously, we reported mitigation Dox-induced and apoptosis by vitamin C (Vit C) isolated cardiomyocytes. In present vivo study rats, investigated effect prophylactic treatment Vit on apoptosis, inflammation, stress, cardiac dysfunction, transporter proteins. Dox (cumulative dose: 15 mg/kg) rats reduced systolic diastolic function...
Experiments were performed to investigate the influence of exercise training on cardiovascular function in mice. Heart rate, arterial pressure, baroreflex sensitivity, and autonomic control heart rate measured conscious, unrestrained male C57/6J sedentary (n = 8) trained mice 8). The protocol used a treadmill (1 h/day; 5 days/wk for 4 wk). Baroreflex sensitivity was evaluated by tachycardic bradycardic responses induced sodium nitroprusside phenylephrine, respectively. Autonomic intrinsic...
The protection from coronary events that young women have is sharply reduced at menopause. Oxidative stress and baroreflex sensitivity impairment of the circulation been demonstrated to increase cardiovascular risk. On other hand, exercise training has indicated as a nonpharmacological treatment for many diseases. aim present study was test hypothesis can improve associated with reduction in oxidative ovariectomized rats, an experimental model Exercise performed on treadmill 8 weeks....
Consumption of high levels fructose in humans and animals leads to metabolic cardiovascular dysfunction. There are questions as the role autonomic changes time course fructose-induced C57/BL male mice were given tap water or (100 g/l) drink for up 2 mo. Groups control (C), 15-day (F15), 60-day (F60). Light-dark patterns arterial pressure (AP) heart rate (HR), their respective variabilities measured. Plasma glucose, lipids, insulin, leptin, resistin, adiponectin, glucose tolerance quantified....
The effects of circadian misalignment and work shift on oxidative stress profile workers have not been explored in the literature. present study aimed to evaluate role (day night) social jetlag - a measure with markers. A cross-sectional was performed 79 men (21-65 years old, 27.56 ± 4.0 kg/m2) who worked night (n = 37) or daytime 42). analyzed variables included anthropometric measures determination systemic levels markers damage antioxidant defense. Social calculated by absolute difference...
Abstract We previously reported that cholinergic stimulation with pyridostigmine (PY) induces anti-inflammatory cell recruitment soon after myocardial infarction (MI). In this study, we evaluated the effects of PY during proliferative phase cardiac repair by analyzing infiltration macrophages, Treg lymphocytes, oxidative stress and inflammatory cytokines. Wistar rats underwent control sham surgery or ligation left coronary artery were randomly allocated to remain untreated (untreated...
COVID-19 has become a dramatic health problem during this century. In addition to high mortality rate, survivors are at increased risk for cardiovascular diseases 1-year after infection. Explanations these manifestations still unclear but can involve constellation of biological alterations. We hypothesized that compared with controls exhibit sympathetic overdrive, vascular dysfunction, cardiac morpho-functional changes, impaired exercise capacity, and oxidative stress.Nineteen severe 19...
Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training an efficient non-pharmacological treatment for cardiac metabolic diseases. The aim of the present study was to investigate effects exercise on hemodynamic diabetic After 1 week induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted 10 weeks a treadmill. Arterial pressure signals obtained processed data acquisition system....
Diabetes and menopause markedly increase the risk of cardiovascular disease in women. The objective present study was to investigate effects exercise training on autonomic dysfunction total mortality diabetic female rats undergoing ovarian hormone deprivation. Female Wistar were divided into ovariectomized groups: sedentary trained controls (streptozotocin, 50 mg/kg IV). Trained groups submitted an protocol a treadmill (8 weeks). baroreflex sensitivity evaluated by heart rate responses...
Abstract Background Because cardiomyopathy is the leading cause of death in diabetic patients, determination myocardial function diabetes mellitus essential. In present study, we provide an integrated approach, using noninvasive echocardiography and invasive hemodynamics to assess early changes rats. Methods Diabetes was induced by streptozotocin injection (STZ, 50 mg/kg). After 30 days, (noninvasive) at rest left ventricular (LV) cannulation rest, during after volume overload, were...
High fructose consumption contributes to metabolic syndrome incidence, whereas exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of in derangements a rat model. Wistar rats receiving overload drinking water (100 g/l) were concomitantly trained on treadmill (FT) or kept sedentary (F) for 10 wk. Control treated with normal also submitted (CT) sedentarism (C). Metabolic evaluations consisted Lee index and glycemia insulin tolerance...
It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of diseases. The aim this study was evaluate effects CT in hypertensive ovariectomized rats undergoing fructose overload blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female were divided into following groups (n = 8/group): sedentary normotensive...
Sedentarism is one of the main risk factors for onset cardiometabolic diseases. Some biomarkers, such as heart rate variability (HRV), have been largely studied and found to be involved in genesis dysfunctions associated with sedentary behavior. However, comparatively few studies focused on female sex. The objective this study was analyze hemodynamic, autonomic quality life parameters at rest response mental stress physically active young women. A total 96 women, 18–30 years age, were...
Background: The metabolic syndrome (MetS) is an obesity-associated disorder of pandemic proportions and limited treatment options. Oxidative stress, low-grade inflammation altered neural autonomic regulation, are important components drivers pathogenesis. Galantamine, acetylcholinesterase inhibitor a cholinergic drug that clinically-approved (for Alzheimer's disease) has been implicated in regulation several conditions characterized with immune derangements. Here we examined the effects...
Myonecrosis is a significant complication of Bothropic envenoming, and standard antivenom treatment ineffective in mitigating local tissue damage. Photobiomodulation has demonstrated potential reducing the effects induced by Bothrops snakebite though underlying mechanisms remain poorly understood. This study investigated photobiomodulation on oxidative stress C2C12 myoblast cells exposed to jararacussu venom. Cells were incubated with venom (12.5 μg/mL) immediately irradiated lasers at...
Doxorubicin is known for its significant cardiotoxicity, driven in part by elevated oxidative stress (OS). Furthermore, preclinical models have demonstrated that doxorubicin induces skeletal muscle atrophy. While vitamin C has been recognized as a valuable pharmacological intervention mitigating cardiac toxicity, impact on doxorubicin-induced atrophy still to be determined. Therefore, this study aimed investigate the effects of rats subjected exposure. Indeed, led reduction body weight and...
Background: Cardiovascular diseases are the leading cause of morbidity and mortality among diabetic patients, with their incidence rising globally. Streptozotocin (STZ)-induced rats, untreated insulin, exhibit human-like symptoms such as hyperglycemia, polydipsia, polyuria, weight loss, cardiomyopathy, neuropathy, oxidative stress. Thus, this study evaluated effects Ilex guayusa tea on cardiovascular, autonomic, metabolic, stress parameters in well its antioxidant phytochemical properties....
Abstract Considering that blood pressure variability (BPV) has been associated with damage to target organs such as the kidneys, this study aimed investigate effects of association hydrochlorothiazide (HCTZ) combined exercise training (CET) on BPV, well morphology, function, inflammation, and oxidative stress in renal tissue. Our was designed experimentally simulate arterial hypertension postmenopausal period females, a condition linked considerable increase cardiovascular risk. To replicate...